Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

YS Aulchenko, IA Hoppenbrouwers, SV Ramagopalan, Linda Broer, Naghmeh Jafari, J Hillert, J Link, W Lundstrom, E Greiner, AD Sadovnick, D Goossens, C van Broeckhoven, J Del-Favero, GC Ebers, Ben Oostra, Cornelia Duijn, Rogier Hintzen

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The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
Original languageUndefined/Unknown
Pages (from-to)1402-1403
Number of pages2
JournalNature Genetics
Issue number12
Publication statusPublished - 2008

Research programs

  • EMC MGC-02-96-01
  • EMC MM-04-44-02
  • EMC NIHES-01-64-02

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