Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

YS Aulchenko; IA Hoppenbrouwers; SV Ramagopalan; Linda Broer; Naghmeh Jafari; J Hillert; J Link; W Lundstrom; E Greiner; AD Sadovnick; D Goossens; C van Broeckhoven; J Del-Favero; GC Ebers; Ben Oostra; Cornelia Duijn; Rogier Hintzen

doi:10.1038/ng.251

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

YS Aulchenko, IA Hoppenbrouwers, SV Ramagopalan, Linda Broer, Naghmeh Jafari, J Hillert, J Link, W Lundstrom, E Greiner, AD Sadovnick, D Goossens, C van Broeckhoven, J Del-Favero, GC Ebers, Ben Oostra, Cornelia Duijn, Rogier Hintzen

Research output: Contribution to journal › Article › Academic › peer-review

157 Citations (Scopus)

Abstract

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

Original language	Undefined/Unknown
Pages (from-to)	1402-1403
Number of pages	2
Journal	Nature Genetics
Volume	40
Issue number	12
DOIs	https://doi.org/10.1038/ng.251
Publication status	Published - 2008

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10.1038/ng.251

http://hdl.handle.net/1765/30208

Cite this

Aulchenko, YS., Hoppenbrouwers, IA., Ramagopalan, SV., Broer, L., Jafari, N., Hillert, J., Link, J., Lundstrom, W., Greiner, E., Sadovnick, AD., Goossens, D., van Broeckhoven, C., Del-Favero, J., Ebers, GC., Oostra, B., Duijn, C., & Hintzen, R. (2008). Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nature Genetics, 40(12), 1402-1403. https://doi.org/10.1038/ng.251

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abstract = "The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.",

author = "YS Aulchenko and IA Hoppenbrouwers and SV Ramagopalan and Linda Broer and Naghmeh Jafari and J Hillert and J Link and W Lundstrom and E Greiner and AD Sadovnick and D Goossens and {van Broeckhoven}, C and J Del-Favero and GC Ebers and Ben Oostra and Cornelia Duijn and Rogier Hintzen",

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Aulchenko, YS, Hoppenbrouwers, IA, Ramagopalan, SV, Broer, L, Jafari, N, Hillert, J, Link, J, Lundstrom, W, Greiner, E, Sadovnick, AD, Goossens, D, van Broeckhoven, C, Del-Favero, J, Ebers, GC, Oostra, B, Duijn, C & Hintzen, R 2008, 'Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis', Nature Genetics, vol. 40, no. 12, pp. 1402-1403. https://doi.org/10.1038/ng.251

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T1 - Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

AU - Aulchenko, YS

AU - Hoppenbrouwers, IA

AU - Ramagopalan, SV

AU - Broer, Linda

AU - Jafari, Naghmeh

AU - Hillert, J

AU - Link, J

AU - Lundstrom, W

AU - Greiner, E

AU - Sadovnick, AD

AU - Goossens, D

AU - van Broeckhoven, C

AU - Del-Favero, J

AU - Ebers, GC

AU - Oostra, Ben

AU - Duijn, Cornelia

AU - Hintzen, Rogier

PY - 2008

Y1 - 2008

N2 - The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

AB - The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

U2 - 10.1038/ng.251

DO - 10.1038/ng.251

M3 - Article

VL - 40

SP - 1402

EP - 1403

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 12

ER -