Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

YS Aulchenko, IA Hoppenbrouwers, SV Ramagopalan, Linda Broer, Naghmeh Jafari, J Hillert, J Link, W Lundstrom, E Greiner, AD Sadovnick, D Goossens, C van Broeckhoven, J Del-Favero, GC Ebers, Ben Oostra, Cornelia Duijn, Rogier Hintzen

Research output: Contribution to journalArticleAcademicpeer-review

157 Citations (Scopus)

Abstract

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
Original languageUndefined/Unknown
Pages (from-to)1402-1403
Number of pages2
JournalNature Genetics
Volume40
Issue number12
DOIs
Publication statusPublished - 2008

Cite this