Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

NR Wray; S Ripke; M Mattheisen; M Trzaskowski; EM Byrne; A Abdellaoui; M J Adams; E Agerbo; TM Air; TMF Andlauer; SA Bacanu; M Baekvad-Hansen; AFT Beekman; TB Bigdeli; EB Binder; DRH Blackwood; J Bryois; HN Buttenschon; J Bybjerg-Grauholm; N Cai; E Castelao; JH Christensen; TK Clarke; JIR Coleman; L Colodro-Conde; B Couvy-Duchesne; N Craddock; GE Crawford; CA Crowley; HS Dashti; G Davies; IJ Deary; F Degenhardt; EM Derks; Nese Direk; CV Dolan; EC Dunn; TC Eley; N Eriksson; V Escott-Price; FHF Kiadeh; HK Finucane; AJ Forstner; J Frank; HA Gaspar; M Gill; P Giusti-Rodriguez; FS Goes; SD Gordon; J Grove; LS Hall; E Hannon; CS Hansen; TF Hansen; S Herms; IB Hickie; P Hoffmann; G Homuth; C Horn; JJ Hottenga; DM Hougaard; M Hu; CL Hyde; M Ising; R Jansen; FL Jin; E Jorgenson; JA Knowles; IS Kohane; J Kraft; WW Kretzschmar; J Krogh; Z Kutalik; JM Lane; YH Li; Y Li; PA Lind; XX Liu; LN Lu; DJ MacIntyre; DF MacKinnon; RM Maier; W Maier; J Marchini; H Mbarek; P McGrath; P McGuffin; SE Medland; D Mehta; CM Middeldorp; E Mihailov; Y Milaneschi; L Milani; J van Mill; FM Mondimore; GW Montgomery; S Mostafavi; N Mullins; M Nauck; B Ng; MG Nivard; DR Nyholt; PF O'Reilly; H Oskarsson; MJ Owen; JN Painter; CB Pedersen; MG Pedersen; RE Peterson; E Pettersson; WJ Peyrot; G Pistis; Daniëlle Posthuma; SM Purcell; JA Quiroz; P Qvist; JP Rice; BP Riley; M Rivera; Saira Mirza; R Saxena; R Schoevers; EC Schulte; Lucy Shen; JX Shi; SI Shyn; E Sigurdsson; GBC Sinnamon; JH Smit; Derek Smith; H Stefansson; S Steinberg; CA Stockmeier; F Streit; J Strohmaier; KE Tansey; H Teismann; A Teumer; W Thompson; PA Thomson; TE Thorgeirsson; C Tian; M Traylor; J Treutlein; V Trubetskoy; André Uitterlinden; D Umbricht; S Van der Auwera; AM van Hemert; A Viktorin; PM Visscher; YP Wang; BT Webb; SM Weinsheimer; J Wellmann; G Willemsen; SH Witt; Y Wu; HLS Xi; Jiaqi Yang; FT Zhang; V Arolt; BT Baune; K Berger; DI Boomsma; S Cichon; U Dannlowski; ECJ de Geus; JR DePaulo; E Domenici; K Domschke; T Esko; HJ Grabe; SP Hamilton; C Hayward; AC Heath; DA Hinds; KS Kendler; S Kloiber; G Lewis; QQS Li; S Lucae; PFA Madden; PK Magnusson; NG Martin; AM McIntosh; A Metspalu; O Mors; PB Mortensen; B Muller-Myhsok; M Nordentoft; MM Nothen; MC O'Donovan; SA Paciga; NL Pedersen; B Penninx; RH Perlis; DJ Porteous; JB Potash; M Preisig; M Rietschel; C Schaefer; TG Schulze; JW Smoller; K Stefansson; Henning Tiemeier; R Uher; H Volzke; MM Weissman; T Werge; AR Winslow; CM Lewis; DF Levinson; G Breen; AD Borglum; PF Sullivan

doi:10.1038/s41588-018-0090-3

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

NR Wray, S Ripke, M Mattheisen, M Trzaskowski, EM Byrne, A Abdellaoui, M J Adams, E Agerbo, TM Air, TMF Andlauer, SA Bacanu, M Baekvad-Hansen, AFT Beekman, TB Bigdeli, EB Binder, DRH Blackwood, J Bryois, HN Buttenschon, J Bybjerg-Grauholm, N CaiE Castelao, JH Christensen, TK Clarke, JIR Coleman, L Colodro-Conde, B Couvy-Duchesne, N Craddock, GE Crawford, CA Crowley, HS Dashti, G Davies, IJ Deary, F Degenhardt, EM Derks, Nese Direk, CV Dolan, EC Dunn, TC Eley, N Eriksson, V Escott-Price, FHF Kiadeh, HK Finucane, AJ Forstner, J Frank, HA Gaspar, M Gill, P Giusti-Rodriguez, FS Goes, SD Gordon, J Grove, LS Hall, E Hannon, CS Hansen, TF Hansen, S Herms, IB Hickie, P Hoffmann, G Homuth, C Horn, JJ Hottenga, DM Hougaard, M Hu, CL Hyde, M Ising, R Jansen, FL Jin, E Jorgenson, JA Knowles, IS Kohane, J Kraft, WW Kretzschmar, J Krogh, Z Kutalik, JM Lane, YH Li, Y Li, PA Lind, XX Liu, LN Lu, DJ MacIntyre, DF MacKinnon, RM Maier, W Maier, J Marchini, H Mbarek, P McGrath, P McGuffin, SE Medland, D Mehta, CM Middeldorp, E Mihailov, Y Milaneschi, L Milani, J van Mill, FM Mondimore, GW Montgomery, S Mostafavi, N Mullins, M Nauck, B Ng, MG Nivard, DR Nyholt, PF O'Reilly, H Oskarsson, MJ Owen, JN Painter, CB Pedersen, MG Pedersen, RE Peterson, E Pettersson, WJ Peyrot, G Pistis, Daniëlle Posthuma, SM Purcell, JA Quiroz, P Qvist, JP Rice, BP Riley, M Rivera, Saira Mirza, R Saxena, R Schoevers, EC Schulte, Lucy Shen, JX Shi, SI Shyn, E Sigurdsson, GBC Sinnamon, JH Smit, Derek Smith, H Stefansson, S Steinberg, CA Stockmeier, F Streit, J Strohmaier, KE Tansey, H Teismann, A Teumer, W Thompson, PA Thomson, TE Thorgeirsson, C Tian, M Traylor, J Treutlein, V Trubetskoy, André Uitterlinden, D Umbricht, S Van der Auwera, AM van Hemert, A Viktorin, PM Visscher, YP Wang, BT Webb, SM Weinsheimer, J Wellmann, G Willemsen, SH Witt, Y Wu, HLS Xi, Jiaqi Yang, FT Zhang, V Arolt, BT Baune, K Berger, DI Boomsma, S Cichon, U Dannlowski, ECJ de Geus, JR DePaulo, E Domenici, K Domschke, T Esko, HJ Grabe, SP Hamilton, C Hayward, AC Heath, DA Hinds, KS Kendler, S Kloiber, G Lewis, QQS Li, S Lucae, PFA Madden, PK Magnusson, NG Martin, AM McIntosh, A Metspalu, O Mors, PB Mortensen, B Muller-Myhsok, M Nordentoft, MM Nothen, MC O'Donovan, SA Paciga, NL Pedersen, B Penninx, RH Perlis, DJ Porteous, JB Potash, M Preisig, M Rietschel, C Schaefer, TG Schulze, JW Smoller, K Stefansson, Henning Tiemeier, R Uher, H Volzke, MM Weissman, T Werge, AR Winslow, CM Lewis, DF Levinson, G Breen, AD Borglum, PF Sullivan

Research output: Contribution to journal › Article › Academic › peer-review

1794 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	668-+
Journal	Nature Genetics
Volume	50
Issue number	5
DOIs	https://doi.org/10.1038/s41588-018-0090-3
Publication status	Published - 2018

Research programs

EMC MM-01-39-09-A
EMC NIHES-01-64-02
EMC ONWAR-01-58-02

Access to Document

10.1038/s41588-018-0090-3

http://hdl.handle.net/1765/106142

Cite this

Wray, NR., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, EM., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, TM., Andlauer, TMF., Bacanu, SA., Baekvad-Hansen, M., Beekman, AFT., Bigdeli, TB., Binder, EB., Blackwood, DRH., Bryois, J., Buttenschon, HN., Bybjerg-Grauholm, J., ... Sullivan, PF. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50(5), 668-+. https://doi.org/10.1038/s41588-018-0090-3

@article{69a2079aafac430bac816e4e13603293,

title = "Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression",

author = "NR Wray and S Ripke and M Mattheisen and M Trzaskowski and EM Byrne and A Abdellaoui and Adams, {M J} and E Agerbo and TM Air and TMF Andlauer and SA Bacanu and M Baekvad-Hansen and AFT Beekman and TB Bigdeli and EB Binder and DRH Blackwood and J Bryois and HN Buttenschon and J Bybjerg-Grauholm and N Cai and E Castelao and JH Christensen and TK Clarke and JIR Coleman and L Colodro-Conde and B Couvy-Duchesne and N Craddock and GE Crawford and CA Crowley and HS Dashti and G Davies and IJ Deary and F Degenhardt and EM Derks and Nese Direk and CV Dolan and EC Dunn and TC Eley and N Eriksson and V Escott-Price and FHF Kiadeh and HK Finucane and AJ Forstner and J Frank and HA Gaspar and M Gill and P Giusti-Rodriguez and FS Goes and SD Gordon and J Grove and LS Hall and E Hannon and CS Hansen and TF Hansen and S Herms and IB Hickie and P Hoffmann and G Homuth and C Horn and JJ Hottenga and DM Hougaard and M Hu and CL Hyde and M Ising and R Jansen and FL Jin and E Jorgenson and JA Knowles and IS Kohane and J Kraft and WW Kretzschmar and J Krogh and Z Kutalik and JM Lane and YH Li and Y Li and PA Lind and XX Liu and LN Lu and DJ MacIntyre and DF MacKinnon and RM Maier and W Maier and J Marchini and H Mbarek and P McGrath and P McGuffin and SE Medland and D Mehta and CM Middeldorp and E Mihailov and Y Milaneschi and L Milani and {van Mill}, J and FM Mondimore and GW Montgomery and S Mostafavi and N Mullins and M Nauck and B Ng and MG Nivard and DR Nyholt and PF O'Reilly and H Oskarsson and MJ Owen and JN Painter and CB Pedersen and MG Pedersen and RE Peterson and E Pettersson and WJ Peyrot and G Pistis and Dani{\"e}lle Posthuma and SM Purcell and JA Quiroz and P Qvist and JP Rice and BP Riley and M Rivera and Saira Mirza and R Saxena and R Schoevers and EC Schulte and Lucy Shen and JX Shi and SI Shyn and E Sigurdsson and GBC Sinnamon and JH Smit and Derek Smith and H Stefansson and S Steinberg and CA Stockmeier and F Streit and J Strohmaier and KE Tansey and H Teismann and A Teumer and W Thompson and PA Thomson and TE Thorgeirsson and C Tian and M Traylor and J Treutlein and V Trubetskoy and Andr{\'e} Uitterlinden and D Umbricht and {Van der Auwera}, S and {van Hemert}, AM and A Viktorin and PM Visscher and YP Wang and BT Webb and SM Weinsheimer and J Wellmann and G Willemsen and SH Witt and Y Wu and HLS Xi and Jiaqi Yang and FT Zhang and V Arolt and BT Baune and K Berger and DI Boomsma and S Cichon and U Dannlowski and {de Geus}, ECJ and JR DePaulo and E Domenici and K Domschke and T Esko and HJ Grabe and SP Hamilton and C Hayward and AC Heath and DA Hinds and KS Kendler and S Kloiber and G Lewis and QQS Li and S Lucae and PFA Madden and PK Magnusson and NG Martin and AM McIntosh and A Metspalu and O Mors and PB Mortensen and B Muller-Myhsok and M Nordentoft and MM Nothen and MC O'Donovan and SA Paciga and NL Pedersen and B Penninx and RH Perlis and DJ Porteous and JB Potash and M Preisig and M Rietschel and C Schaefer and TG Schulze and JW Smoller and K Stefansson and Henning Tiemeier and R Uher and H Volzke and MM Weissman and T Werge and AR Winslow and CM Lewis and DF Levinson and G Breen and AD Borglum and PF Sullivan",

year = "2018",

doi = "10.1038/s41588-018-0090-3",

language = "Undefined/Unknown",

volume = "50",

pages = "668--+",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "5",

}

Wray, NR, Ripke, S, Mattheisen, M, Trzaskowski, M, Byrne, EM, Abdellaoui, A, Adams, MJ, Agerbo, E, Air, TM, Andlauer, TMF, Bacanu, SA, Baekvad-Hansen, M, Beekman, AFT, Bigdeli, TB, Binder, EB, Blackwood, DRH, Bryois, J, Buttenschon, HN, Bybjerg-Grauholm, J, Cai, N, Castelao, E, Christensen, JH, Clarke, TK, Coleman, JIR, Colodro-Conde, L, Couvy-Duchesne, B, Craddock, N, Crawford, GE, Crowley, CA, Dashti, HS, Davies, G, Deary, IJ, Degenhardt, F, Derks, EM, Direk, N, Dolan, CV, Dunn, EC, Eley, TC, Eriksson, N, Escott-Price, V, Kiadeh, FHF, Finucane, HK, Forstner, AJ, Frank, J, Gaspar, HA, Gill, M, Giusti-Rodriguez, P, Goes, FS, Gordon, SD, Grove, J, Hall, LS, Hannon, E, Hansen, CS, Hansen, TF, Herms, S, Hickie, IB, Hoffmann, P, Homuth, G, Horn, C, Hottenga, JJ, Hougaard, DM, Hu, M, Hyde, CL, Ising, M, Jansen, R, Jin, FL, Jorgenson, E, Knowles, JA, Kohane, IS, Kraft, J, Kretzschmar, WW, Krogh, J, Kutalik, Z, Lane, JM, Li, YH, Li, Y, Lind, PA, Liu, XX, Lu, LN, MacIntyre, DJ, MacKinnon, DF, Maier, RM, Maier, W, Marchini, J, Mbarek, H, McGrath, P, McGuffin, P, Medland, SE, Mehta, D, Middeldorp, CM, Mihailov, E, Milaneschi, Y, Milani, L, van Mill, J, Mondimore, FM, Montgomery, GW, Mostafavi, S, Mullins, N, Nauck, M, Ng, B, Nivard, MG, Nyholt, DR, O'Reilly, PF, Oskarsson, H, Owen, MJ, Painter, JN, Pedersen, CB, Pedersen, MG, Peterson, RE, Pettersson, E, Peyrot, WJ, Pistis, G, Posthuma, D, Purcell, SM, Quiroz, JA, Qvist, P, Rice, JP, Riley, BP, Rivera, M, Mirza, S, Saxena, R, Schoevers, R, Schulte, EC, Shen, L, Shi, JX, Shyn, SI, Sigurdsson, E, Sinnamon, GBC, Smit, JH, Smith, D, Stefansson, H, Steinberg, S, Stockmeier, CA, Streit, F, Strohmaier, J, Tansey, KE, Teismann, H, Teumer, A, Thompson, W, Thomson, PA, Thorgeirsson, TE, Tian, C, Traylor, M, Treutlein, J, Trubetskoy, V, Uitterlinden, A, Umbricht, D, Van der Auwera, S, van Hemert, AM, Viktorin, A, Visscher, PM, Wang, YP, Webb, BT, Weinsheimer, SM, Wellmann, J, Willemsen, G, Witt, SH, Wu, Y, Xi, HLS, Yang, J, Zhang, FT, Arolt, V, Baune, BT, Berger, K, Boomsma, DI, Cichon, S, Dannlowski, U, de Geus, ECJ, DePaulo, JR, Domenici, E, Domschke, K, Esko, T, Grabe, HJ, Hamilton, SP, Hayward, C, Heath, AC, Hinds, DA, Kendler, KS, Kloiber, S, Lewis, G, Li, QQS, Lucae, S, Madden, PFA, Magnusson, PK, Martin, NG, McIntosh, AM, Metspalu, A, Mors, O, Mortensen, PB, Muller-Myhsok, B, Nordentoft, M, Nothen, MM, O'Donovan, MC, Paciga, SA, Pedersen, NL, Penninx, B, Perlis, RH, Porteous, DJ, Potash, JB, Preisig, M, Rietschel, M, Schaefer, C, Schulze, TG, Smoller, JW, Stefansson, K, Tiemeier, H, Uher, R, Volzke, H, Weissman, MM, Werge, T, Winslow, AR, Lewis, CM, Levinson, DF, Breen, G, Borglum, AD & Sullivan, PF 2018, 'Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression', Nature Genetics, vol. 50, no. 5, pp. 668-+. https://doi.org/10.1038/s41588-018-0090-3

TY - JOUR

T1 - Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

AU - Wray, NR

AU - Ripke, S

AU - Mattheisen, M

AU - Trzaskowski, M

AU - Byrne, EM

AU - Abdellaoui, A

AU - Adams, M J

AU - Agerbo, E

AU - Air, TM

AU - Andlauer, TMF

AU - Bacanu, SA

AU - Baekvad-Hansen, M

AU - Beekman, AFT

AU - Bigdeli, TB

AU - Binder, EB

AU - Blackwood, DRH

AU - Bryois, J

AU - Buttenschon, HN

AU - Bybjerg-Grauholm, J

AU - Cai, N

AU - Castelao, E

AU - Christensen, JH

AU - Clarke, TK

AU - Coleman, JIR

AU - Colodro-Conde, L

AU - Couvy-Duchesne, B

AU - Craddock, N

AU - Crawford, GE

AU - Crowley, CA

AU - Dashti, HS

AU - Davies, G

AU - Deary, IJ

AU - Degenhardt, F

AU - Derks, EM

AU - Direk, Nese

AU - Dolan, CV

AU - Dunn, EC

AU - Eley, TC

AU - Eriksson, N

AU - Escott-Price, V

AU - Kiadeh, FHF

AU - Finucane, HK

AU - Forstner, AJ

AU - Frank, J

AU - Gaspar, HA

AU - Gill, M

AU - Giusti-Rodriguez, P

AU - Goes, FS

AU - Gordon, SD

AU - Grove, J

AU - Hall, LS

AU - Hannon, E

AU - Hansen, CS

AU - Hansen, TF

AU - Herms, S

AU - Hickie, IB

AU - Hoffmann, P

AU - Homuth, G

AU - Horn, C

AU - Hottenga, JJ

AU - Hougaard, DM

AU - Hu, M

AU - Hyde, CL

AU - Ising, M

AU - Jansen, R

AU - Jin, FL

AU - Jorgenson, E

AU - Knowles, JA

AU - Kohane, IS

AU - Kraft, J

AU - Kretzschmar, WW

AU - Krogh, J

AU - Kutalik, Z

AU - Lane, JM

AU - Li, YH

AU - Li, Y

AU - Lind, PA

AU - Liu, XX

AU - Lu, LN

AU - MacIntyre, DJ

AU - MacKinnon, DF

AU - Maier, RM

AU - Maier, W

AU - Marchini, J

AU - Mbarek, H

AU - McGrath, P

AU - McGuffin, P

AU - Medland, SE

AU - Mehta, D

AU - Middeldorp, CM

AU - Mihailov, E

AU - Milaneschi, Y

AU - Milani, L

AU - van Mill, J

AU - Mondimore, FM

AU - Montgomery, GW

AU - Mostafavi, S

AU - Mullins, N

AU - Nauck, M

AU - Ng, B

AU - Nivard, MG

AU - Nyholt, DR

AU - O'Reilly, PF

AU - Oskarsson, H

AU - Owen, MJ

AU - Painter, JN

AU - Pedersen, CB

AU - Pedersen, MG

AU - Peterson, RE

AU - Pettersson, E

AU - Peyrot, WJ

AU - Pistis, G

AU - Posthuma, Daniëlle

AU - Purcell, SM

AU - Quiroz, JA

AU - Qvist, P

AU - Rice, JP

AU - Riley, BP

AU - Rivera, M

AU - Mirza, Saira

AU - Saxena, R

AU - Schoevers, R

AU - Schulte, EC

AU - Shen, Lucy

AU - Shi, JX

AU - Shyn, SI

AU - Sigurdsson, E

AU - Sinnamon, GBC

AU - Smit, JH

AU - Smith, Derek

AU - Stefansson, H

AU - Steinberg, S

AU - Stockmeier, CA

AU - Streit, F

AU - Strohmaier, J

AU - Tansey, KE

AU - Teismann, H

AU - Teumer, A

AU - Thompson, W

AU - Thomson, PA

AU - Thorgeirsson, TE

AU - Tian, C

AU - Traylor, M

AU - Treutlein, J

AU - Trubetskoy, V

AU - Uitterlinden, André

AU - Umbricht, D

AU - Van der Auwera, S

AU - van Hemert, AM

AU - Viktorin, A

AU - Visscher, PM

AU - Wang, YP

AU - Webb, BT

AU - Weinsheimer, SM

AU - Wellmann, J

AU - Willemsen, G

AU - Witt, SH

AU - Wu, Y

AU - Xi, HLS

AU - Yang, Jiaqi

AU - Zhang, FT

AU - Arolt, V

AU - Baune, BT

AU - Berger, K

AU - Boomsma, DI

AU - Cichon, S

AU - Dannlowski, U

AU - de Geus, ECJ

AU - DePaulo, JR

AU - Domenici, E

AU - Domschke, K

AU - Esko, T

AU - Grabe, HJ

AU - Hamilton, SP

AU - Hayward, C

AU - Heath, AC

AU - Hinds, DA

AU - Kendler, KS

AU - Kloiber, S

AU - Lewis, G

AU - Li, QQS

AU - Lucae, S

AU - Madden, PFA

AU - Magnusson, PK

AU - Martin, NG

AU - McIntosh, AM

AU - Metspalu, A

AU - Mors, O

AU - Mortensen, PB

AU - Muller-Myhsok, B

AU - Nordentoft, M

AU - Nothen, MM

AU - O'Donovan, MC

AU - Paciga, SA

AU - Pedersen, NL

AU - Penninx, B

AU - Perlis, RH

AU - Porteous, DJ

AU - Potash, JB

AU - Preisig, M

AU - Rietschel, M

AU - Schaefer, C

AU - Schulze, TG

AU - Smoller, JW

AU - Stefansson, K

AU - Tiemeier, Henning

AU - Uher, R

AU - Volzke, H

AU - Weissman, MM

AU - Werge, T

AU - Winslow, AR

AU - Lewis, CM

AU - Levinson, DF

AU - Breen, G

AU - Borglum, AD

AU - Sullivan, PF

PY - 2018

Y1 - 2018

U2 - 10.1038/s41588-018-0090-3

DO - 10.1038/s41588-018-0090-3

M3 - Article

C2 - 29700475

SN - 1061-4036

VL - 50

SP - 668-+

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -