Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

W van Rheenen; A Shatunov; AM Dekker; RL McLaughlin; FP Diekstra; SL Pulit; R A A van der Spek; U Vosa; S de Jong; MR Robinson; Jiaqi Yang; I Fogh; PTC van Doormaal; G H P Tazelaar; M Koppers; AM Blokhuis; W Sproviero; A R Jones; K P Kenna; KR van Eijk; O Harschnitz; R D Schellevis; W J Brands; J Medic; A Menelaou; A Vajda; N Ticozzi; K Lin; B Rogelj; K Vrabec; M Ravnik-Glavac; B Koritnik; J Zidar; L Leonardis; L D Groselj; S Millecamps; F Salachas; V Meininger; M Carvalho; S Pinto; J S Mora; R Rojas-Garcia; M Polak; S Chandran; S Colville; R Swingler; KE Morrison; PJ Shaw; J Hardy; RW Orrell; A Pittman; K Sidle; P Fratta; A Malaspina; S Topp; S Petri; S Abdulla; C Drepper; M Sendtner; T Meyer; RA Ophoff; KA Staats; M Wiedau-Pazos; C Lomen-Hoerth; VM Van Deerlin; JQ Trojanowski; L Elman; L McCluskey; AN Basak; C Tunca; H Hanizeiy; Y Parman; T Meitinger; P Lichtner; M Radivojkov-Blagojevic; C R Andres; C Maurel; G Bensimon; B Landwehrmeyer; A Brice; C A M Payan; S Saker-Delye; A Durr; NW Wood; L Tittmann; W Lieb; A Franke; M Rietschel; S Cichon; MM Nothen; P Amouyel; C Tzourio; JF Dartigues; André Uitterlinden; Fernando Rivadeneira; Karol Estrada Gil; Bert Hofman; C Curtis; HM Blauw; AJ van der Kooi; M de Visser; A Goris; M Weber; CE Shaw; B N Smith; O Pansarasa; C Cereda; R Del Bo; G P Comi; S D'Alfonso; C Bertolin; G Soraru; L Mazzini; V Pensato; C Gellera; C Tiloca; A Ratti; A Calvo; C Moglia; M Brunetti; S Arcuti; R Capozzo; C Zecca; C Lunetta; S Penco; Natalia Riva; A Padovani; M Filosto; B Muller; R J Stuit; I Blair; Kai Zhang; E P McCann; J A Fifita; G A Nicholson; D B Rowe; R Pamphlett; M C Kiernan; J Grosskreutz; O W Witte; T Ringer; T Prell; B Stubendorff; I Kurth; CA Hubner; PN Leigh; F Casale; A Chio; E Beghi; E Pupillo; R Tortelli; G Logroscino; J Powell; AC Ludolph; JH Weishaupt; W Robberecht; P van Damme; L Franke; TH Pers; RH Brown; JD Glass; JE Landers; O Hardiman; PM Andersen; P Corcia; P Vourc'h; V Silani; NR Wray; PM Visscher; PIW de Bakker; MA van Es; RJ Pasterkamp; CM Lewis; G Breen; A Al-Chalabi; LH van den Berg; JH Veldink

doi:10.1038/ng.3622

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

W van Rheenen, A Shatunov, AM Dekker, RL McLaughlin, FP Diekstra, SL Pulit, R A A van der Spek, U Vosa, S de Jong, MR Robinson, Jiaqi Yang, I Fogh, PTC van Doormaal, G H P Tazelaar, M Koppers, AM Blokhuis, W Sproviero, A R Jones, K P Kenna, KR van EijkO Harschnitz, R D Schellevis, W J Brands, J Medic, A Menelaou, A Vajda, N Ticozzi, K Lin, B Rogelj, K Vrabec, M Ravnik-Glavac, B Koritnik, J Zidar, L Leonardis, L D Groselj, S Millecamps, F Salachas, V Meininger, M Carvalho, S Pinto, J S Mora, R Rojas-Garcia, M Polak, S Chandran, S Colville, R Swingler, KE Morrison, PJ Shaw, J Hardy, RW Orrell, A Pittman, K Sidle, P Fratta, A Malaspina, S Topp, S Petri, S Abdulla, C Drepper, M Sendtner, T Meyer, RA Ophoff, KA Staats, M Wiedau-Pazos, C Lomen-Hoerth, VM Van Deerlin, JQ Trojanowski, L Elman, L McCluskey, AN Basak, C Tunca, H Hanizeiy, Y Parman, T Meitinger, P Lichtner, M Radivojkov-Blagojevic, C R Andres, C Maurel, G Bensimon, B Landwehrmeyer, A Brice, C A M Payan, S Saker-Delye, A Durr, NW Wood, L Tittmann, W Lieb, A Franke, M Rietschel, S Cichon, MM Nothen, P Amouyel, C Tzourio, JF Dartigues, André Uitterlinden, Fernando Rivadeneira, Karol Estrada Gil, Bert Hofman, C Curtis, HM Blauw, AJ van der Kooi, M de Visser, A Goris, M Weber, CE Shaw, B N Smith, O Pansarasa, C Cereda, R Del Bo, G P Comi, S D'Alfonso, C Bertolin, G Soraru, L Mazzini, V Pensato, C Gellera, C Tiloca, A Ratti, A Calvo, C Moglia, M Brunetti, S Arcuti, R Capozzo, C Zecca, C Lunetta, S Penco, Natalia Riva, A Padovani, M Filosto, B Muller, R J Stuit, I Blair, Kai Zhang, E P McCann, J A Fifita, G A Nicholson, D B Rowe, R Pamphlett, M C Kiernan, J Grosskreutz, O W Witte, T Ringer, T Prell, B Stubendorff, I Kurth, CA Hubner, PN Leigh, F Casale, A Chio, E Beghi, E Pupillo, R Tortelli, G Logroscino, J Powell, AC Ludolph, JH Weishaupt, W Robberecht, P van Damme, L Franke, TH Pers, RH Brown, JD Glass, JE Landers, O Hardiman, PM Andersen, P Corcia, P Vourc'h, V Silani, NR Wray, PM Visscher, PIW de Bakker, MA van Es, RJ Pasterkamp, CM Lewis, G Breen, A Al-Chalabi, LH van den Berg, JH Veldink

Research output: Contribution to journal › Article › Academic › peer-review

427 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	1043-1048
Number of pages	6
Journal	Nature Genetics
Volume	48
Issue number	9
DOIs	https://doi.org/10.1038/ng.3622
Publication status	Published - 2016

Research programs

EMC MM-01-39-09-A
EMC NIHES-01-64-01

Access to Document

10.1038/ng.3622

http://hdl.handle.net/1765/97312

Cite this

van Rheenen, W., Shatunov, A., Dekker, AM., McLaughlin, RL., Diekstra, FP., Pulit, SL., van der Spek, R. A. A., Vosa, U., de Jong, S., Robinson, MR., Yang, J., Fogh, I., van Doormaal, PTC., Tazelaar, G. H. P., Koppers, M., Blokhuis, AM., Sproviero, W., Jones, A. R., Kenna, K. P., ... Veldink, JH. (2016). Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nature Genetics, 48(9), 1043-1048. https://doi.org/10.1038/ng.3622

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van Rheenen, W, Shatunov, A, Dekker, AM, McLaughlin, RL, Diekstra, FP, Pulit, SL, van der Spek, RAA, Vosa, U, de Jong, S, Robinson, MR, Yang, J, Fogh, I, van Doormaal, PTC, Tazelaar, GHP, Koppers, M, Blokhuis, AM, Sproviero, W, Jones, AR, Kenna, KP, van Eijk, KR, Harschnitz, O, Schellevis, RD, Brands, WJ, Medic, J, Menelaou, A, Vajda, A, Ticozzi, N, Lin, K, Rogelj, B, Vrabec, K, Ravnik-Glavac, M, Koritnik, B, Zidar, J, Leonardis, L, Groselj, LD, Millecamps, S, Salachas, F, Meininger, V, Carvalho, M, Pinto, S, Mora, JS, Rojas-Garcia, R, Polak, M, Chandran, S, Colville, S, Swingler, R, Morrison, KE, Shaw, PJ, Hardy, J, Orrell, RW, Pittman, A, Sidle, K, Fratta, P, Malaspina, A, Topp, S, Petri, S, Abdulla, S, Drepper, C, Sendtner, M, Meyer, T, Ophoff, RA, Staats, KA, Wiedau-Pazos, M, Lomen-Hoerth, C, Van Deerlin, VM, Trojanowski, JQ, Elman, L, McCluskey, L, Basak, AN, Tunca, C, Hanizeiy, H, Parman, Y, Meitinger, T, Lichtner, P, Radivojkov-Blagojevic, M, Andres, CR, Maurel, C, Bensimon, G, Landwehrmeyer, B, Brice, A, Payan, CAM, Saker-Delye, S, Durr, A, Wood, NW, Tittmann, L, Lieb, W, Franke, A, Rietschel, M, Cichon, S, Nothen, MM, Amouyel, P, Tzourio, C, Dartigues, JF, Uitterlinden, A , Rivadeneira, F, Estrada Gil, K, Hofman, B, Curtis, C, Blauw, HM, van der Kooi, AJ, de Visser, M, Goris, A, Weber, M, Shaw, CE, Smith, BN, Pansarasa, O, Cereda, C, Del Bo, R, Comi, GP, D'Alfonso, S, Bertolin, C, Soraru, G, Mazzini, L, Pensato, V, Gellera, C, Tiloca, C, Ratti, A, Calvo, A, Moglia, C, Brunetti, M, Arcuti, S, Capozzo, R, Zecca, C, Lunetta, C, Penco, S, Riva, N, Padovani, A, Filosto, M, Muller, B, Stuit, RJ, Blair, I, Zhang, K, McCann, EP, Fifita, JA, Nicholson, GA, Rowe, DB, Pamphlett, R, Kiernan, MC, Grosskreutz, J, Witte, OW, Ringer, T, Prell, T, Stubendorff, B, Kurth, I, Hubner, CA, Leigh, PN, Casale, F, Chio, A, Beghi, E, Pupillo, E, Tortelli, R, Logroscino, G, Powell, J, Ludolph, AC, Weishaupt, JH, Robberecht, W, van Damme, P, Franke, L, Pers, TH, Brown, RH, Glass, JD, Landers, JE, Hardiman, O, Andersen, PM, Corcia, P, Vourc'h, P, Silani, V, Wray, NR, Visscher, PM, de Bakker, PIW, van Es, MA, Pasterkamp, RJ, Lewis, CM, Breen, G, Al-Chalabi, A, van den Berg, LH & Veldink, JH 2016, 'Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis', Nature Genetics, vol. 48, no. 9, pp. 1043-1048. https://doi.org/10.1038/ng.3622

TY - JOUR

T1 - Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

AU - van Rheenen, W

AU - Shatunov, A

AU - Dekker, AM

AU - McLaughlin, RL

AU - Diekstra, FP

AU - Pulit, SL

AU - van der Spek, R A A

AU - Vosa, U

AU - de Jong, S

AU - Robinson, MR

AU - Yang, Jiaqi

AU - Fogh, I

AU - van Doormaal, PTC

AU - Tazelaar, G H P

AU - Koppers, M

AU - Blokhuis, AM

AU - Sproviero, W

AU - Jones, A R

AU - Kenna, K P

AU - van Eijk, KR

AU - Harschnitz, O

AU - Schellevis, R D

AU - Brands, W J

AU - Medic, J

AU - Menelaou, A

AU - Vajda, A

AU - Ticozzi, N

AU - Lin, K

AU - Rogelj, B

AU - Vrabec, K

AU - Ravnik-Glavac, M

AU - Koritnik, B

AU - Zidar, J

AU - Leonardis, L

AU - Groselj, L D

AU - Millecamps, S

AU - Salachas, F

AU - Meininger, V

AU - Carvalho, M

AU - Pinto, S

AU - Mora, J S

AU - Rojas-Garcia, R

AU - Polak, M

AU - Chandran, S

AU - Colville, S

AU - Swingler, R

AU - Morrison, KE

AU - Shaw, PJ

AU - Hardy, J

AU - Orrell, RW

AU - Pittman, A

AU - Sidle, K

AU - Fratta, P

AU - Malaspina, A

AU - Topp, S

AU - Petri, S

AU - Abdulla, S

AU - Drepper, C

AU - Sendtner, M

AU - Meyer, T

AU - Ophoff, RA

AU - Staats, KA

AU - Wiedau-Pazos, M

AU - Lomen-Hoerth, C

AU - Van Deerlin, VM

AU - Trojanowski, JQ

AU - Elman, L

AU - McCluskey, L

AU - Basak, AN

AU - Tunca, C

AU - Hanizeiy, H

AU - Parman, Y

AU - Meitinger, T

AU - Lichtner, P

AU - Radivojkov-Blagojevic, M

AU - Andres, C R

AU - Maurel, C

AU - Bensimon, G

AU - Landwehrmeyer, B

AU - Brice, A

AU - Payan, C A M

AU - Saker-Delye, S

AU - Durr, A

AU - Wood, NW

AU - Tittmann, L

AU - Lieb, W

AU - Franke, A

AU - Rietschel, M

AU - Cichon, S

AU - Nothen, MM

AU - Amouyel, P

AU - Tzourio, C

AU - Dartigues, JF

AU - Uitterlinden, André

AU - Rivadeneira, Fernando

AU - Estrada Gil, Karol

AU - Hofman, Bert

AU - Curtis, C

AU - Blauw, HM

AU - van der Kooi, AJ

AU - de Visser, M

AU - Goris, A

AU - Weber, M

AU - Shaw, CE

AU - Smith, B N

AU - Pansarasa, O

AU - Cereda, C

AU - Del Bo, R

AU - Comi, G P

AU - D'Alfonso, S

AU - Bertolin, C

AU - Soraru, G

AU - Mazzini, L

AU - Pensato, V

AU - Gellera, C

AU - Tiloca, C

AU - Ratti, A

AU - Calvo, A

AU - Moglia, C

AU - Brunetti, M

AU - Arcuti, S

AU - Capozzo, R

AU - Zecca, C

AU - Lunetta, C

AU - Penco, S

AU - Riva, Natalia

AU - Padovani, A

AU - Filosto, M

AU - Muller, B

AU - Stuit, R J

AU - Blair, I

AU - Zhang, Kai

AU - McCann, E P

AU - Fifita, J A

AU - Nicholson, G A

AU - Rowe, D B

AU - Pamphlett, R

AU - Kiernan, M C

AU - Grosskreutz, J

AU - Witte, O W

AU - Ringer, T

AU - Prell, T

AU - Stubendorff, B

AU - Kurth, I

AU - Hubner, CA

AU - Leigh, PN

AU - Casale, F

AU - Chio, A

AU - Beghi, E

AU - Pupillo, E

AU - Tortelli, R

AU - Logroscino, G

AU - Powell, J

AU - Ludolph, AC

AU - Weishaupt, JH

AU - Robberecht, W

AU - van Damme, P

AU - Franke, L

AU - Pers, TH

AU - Brown, RH

AU - Glass, JD

AU - Landers, JE

AU - Hardiman, O

AU - Andersen, PM

AU - Corcia, P

AU - Vourc'h, P

AU - Silani, V

AU - Wray, NR

AU - Visscher, PM

AU - de Bakker, PIW

AU - van Es, MA

AU - Pasterkamp, RJ

AU - Lewis, CM

AU - Breen, G

AU - Al-Chalabi, A

AU - van den Berg, LH

AU - Veldink, JH

PY - 2016

Y1 - 2016

U2 - 10.1038/ng.3622

DO - 10.1038/ng.3622

M3 - Article

SN - 1061-4036

VL - 48

SP - 1043

EP - 1048

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -