Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

W van Rheenen; A Shatunov; AM Dekker; RL McLaughlin; FP Diekstra; SL Pulit; R A A van der Spek; U Vosa; S de Jong; MR Robinson; Jiaqi Yang; I Fogh; PTC van Doormaal; G H P Tazelaar; M Koppers; AM Blokhuis; W Sproviero; A R Jones; K P Kenna; KR van Eijk; O Harschnitz; R D Schellevis; W J Brands; J Medic; A Menelaou; A Vajda; N Ticozzi; K Lin; B Rogelj; K Vrabec; M Ravnik-Glavac; B Koritnik; J Zidar; L Leonardis; L D Groselj; S Millecamps; F Salachas; V Meininger; M Carvalho; S Pinto; J S Mora; R Rojas-Garcia; M Polak; S Chandran; S Colville; R Swingler; KE Morrison; PJ Shaw; J Hardy; RW Orrell; A Pittman; K Sidle; P Fratta; A Malaspina; S Topp; S Petri; S Abdulla; C Drepper; M Sendtner; T Meyer; RA Ophoff; KA Staats; M Wiedau-Pazos; C Lomen-Hoerth; VM Van Deerlin; JQ Trojanowski; L Elman; L McCluskey; AN Basak; C Tunca; H Hanizeiy; Y Parman; T Meitinger; P Lichtner; M Radivojkov-Blagojevic; C R Andres; C Maurel; G Bensimon; B Landwehrmeyer; A Brice; C A M Payan; S Saker-Delye; A Durr; NW Wood; L Tittmann; W Lieb; A Franke; M Rietschel; S Cichon; MM Nothen; P Amouyel; C Tzourio; JF Dartigues; André Uitterlinden; Fernando Rivadeneira; Karol Estrada Gil; Bert Hofman; C Curtis; HM Blauw; AJ van der Kooi; M de Visser; A Goris; M Weber; CE Shaw; B N Smith; O Pansarasa; C Cereda; R Del Bo; G P Comi; S D'Alfonso; C Bertolin; G Soraru; L Mazzini; V Pensato; C Gellera; C Tiloca; A Ratti; A Calvo; C Moglia; M Brunetti; S Arcuti; R Capozzo; C Zecca; C Lunetta; S Penco; Natalia Riva; A Padovani; M Filosto; B Muller; R J Stuit; I Blair; Kai Zhang; E P McCann; J A Fifita; G A Nicholson; D B Rowe; R Pamphlett; M C Kiernan; J Grosskreutz; O W Witte; T Ringer; T Prell; B Stubendorff; I Kurth; CA Hubner; PN Leigh; F Casale; A Chio; E Beghi; E Pupillo; R Tortelli; G Logroscino; J Powell; AC Ludolph; JH Weishaupt; W Robberecht; P van Damme; L Franke; TH Pers; RH Brown; JD Glass; JE Landers; O Hardiman; PM Andersen; P Corcia; P Vourc'h; V Silani; NR Wray; PM Visscher; PIW de Bakker; MA van Es; RJ Pasterkamp; CM Lewis; G Breen; A Al-Chalabi; LH van den Berg; JH Veldink

doi:10.1038/ng.3622

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

W van Rheenen
, A Shatunov
, AM Dekker
, RL McLaughlin
, FP Diekstra
, SL Pulit
, R A A van der Spek
, U Vosa
, S de Jong
, MR Robinson
, Jiaqi Yang
, I Fogh
, PTC van Doormaal
, G H P Tazelaar
, M Koppers
, AM Blokhuis
, W Sproviero
, A R Jones
, K P Kenna
, KR van Eijk

O Harschnitz, R D Schellevis, W J Brands, J Medic, A Menelaou, A Vajda, N Ticozzi, K Lin, B Rogelj, K Vrabec, M Ravnik-Glavac, B Koritnik, J Zidar, L Leonardis, L D Groselj, S Millecamps, F Salachas, V Meininger, M Carvalho, S Pinto, J S Mora, R Rojas-Garcia, M Polak, S Chandran, S Colville, R Swingler, KE Morrison, PJ Shaw, J Hardy, RW Orrell, A Pittman, K Sidle, P Fratta, A Malaspina, S Topp, S Petri, S Abdulla, C Drepper, M Sendtner, T Meyer, RA Ophoff, KA Staats, M Wiedau-Pazos, C Lomen-Hoerth, VM Van Deerlin, JQ Trojanowski, L Elman, L McCluskey, AN Basak, C Tunca, H Hanizeiy, Y Parman, T Meitinger, P Lichtner, M Radivojkov-Blagojevic, C R Andres, C Maurel, G Bensimon, B Landwehrmeyer, A Brice, C A M Payan, S Saker-Delye, A Durr, NW Wood, L Tittmann, W Lieb, A Franke, M Rietschel, S Cichon, MM Nothen, P Amouyel, C Tzourio, JF Dartigues, André Uitterlinden, Fernando Rivadeneira, Karol Estrada Gil, Bert Hofman, C Curtis, HM Blauw, AJ van der Kooi, M de Visser, A Goris, M Weber, CE Shaw, B N Smith, O Pansarasa, C Cereda, R Del Bo, G P Comi, S D'Alfonso, C Bertolin, G Soraru, L Mazzini, V Pensato, C Gellera, C Tiloca, A Ratti, A Calvo, C Moglia, M Brunetti, S Arcuti, R Capozzo, C Zecca, C Lunetta, S Penco, Natalia Riva, A Padovani, M Filosto, B Muller, R J Stuit, I Blair, Kai Zhang, E P McCann, J A Fifita, G A Nicholson, D B Rowe, R Pamphlett, M C Kiernan, J Grosskreutz, O W Witte, T Ringer, T Prell, B Stubendorff, I Kurth, CA Hubner, PN Leigh, F Casale, A Chio, E Beghi, E Pupillo, R Tortelli, G Logroscino, J Powell, AC Ludolph, JH Weishaupt, W Robberecht, P van Damme, L Franke, TH Pers, RH Brown, JD Glass, JE Landers, O Hardiman, PM Andersen, P Corcia, P Vourc'h, V Silani, NR Wray, PM Visscher, PIW de Bakker, MA van Es, RJ Pasterkamp, CM Lewis, G Breen, A Al-Chalabi, LH van den Berg, JH Veldink

External organisation

Research output: Contribution to journal › Article › Academic › peer-review

472 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	1043-1048
Number of pages	6
Journal	Nature Genetics
Volume	48
Issue number	9
DOIs	https://doi.org/10.1038/ng.3622
Publication status	Published - 2016

Research programs

EMC MM-01-39-09-A
EMC NIHES-01-64-01

Access to Document

10.1038/ng.3622

http://hdl.handle.net/1765/97312

Cite this

van Rheenen, W., Shatunov, A., Dekker, AM., McLaughlin, RL., Diekstra, FP., Pulit, SL., van der Spek, R. A. A., Vosa, U., de Jong, S., Robinson, MR., Yang, J., Fogh, I., van Doormaal, PTC., Tazelaar, G. H. P., Koppers, M., Blokhuis, AM., Sproviero, W., Jones, A. R., Kenna, K. P., ... Veldink, JH. (2016). Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nature Genetics, 48(9), 1043-1048. https://doi.org/10.1038/ng.3622

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author = "\{van Rheenen\}, W and A Shatunov and AM Dekker and RL McLaughlin and FP Diekstra and SL Pulit and \{van der Spek\}, \{R A A\} and U Vosa and \{de Jong\}, S and MR Robinson and Jiaqi Yang and I Fogh and \{van Doormaal\}, PTC and Tazelaar, \{G H P\} and M Koppers and AM Blokhuis and W Sproviero and Jones, \{A R\} and Kenna, \{K P\} and \{van Eijk\}, KR and O Harschnitz and Schellevis, \{R D\} and Brands, \{W J\} and J Medic and A Menelaou and A Vajda and N Ticozzi and K Lin and B Rogelj and K Vrabec and M Ravnik-Glavac and B Koritnik and J Zidar and L Leonardis and Groselj, \{L D\} and S Millecamps and F Salachas and V Meininger and M Carvalho and S Pinto and Mora, \{J S\} and R Rojas-Garcia and M Polak and S Chandran and S Colville and R Swingler and KE Morrison and PJ Shaw and J Hardy and RW Orrell and A Pittman and K Sidle and P Fratta and A Malaspina and S Topp and S Petri and S Abdulla and C Drepper and M Sendtner and T Meyer and RA Ophoff and KA Staats and M Wiedau-Pazos and C Lomen-Hoerth and \{Van Deerlin\}, VM and JQ Trojanowski and L Elman and L McCluskey and AN Basak and C Tunca and H Hanizeiy and Y Parman and T Meitinger and P Lichtner and M Radivojkov-Blagojevic and Andres, \{C R\} and C Maurel and G Bensimon and B Landwehrmeyer and A Brice and Payan, \{C A M\} and S Saker-Delye and A Durr and NW Wood and L Tittmann and W Lieb and A Franke and M Rietschel and S Cichon and MM Nothen and P Amouyel and C Tzourio and JF Dartigues and Andr{\'e} Uitterlinden and Fernando Rivadeneira and \{Estrada Gil\}, Karol and Bert Hofman and C Curtis and HM Blauw and \{van der Kooi\}, AJ and \{de Visser\}, M and A Goris and M Weber and CE Shaw and Smith, \{B N\} and O Pansarasa and C Cereda and \{Del Bo\}, R and Comi, \{G P\} and S D'Alfonso and C Bertolin and G Soraru and L Mazzini and V Pensato and C Gellera and C Tiloca and A Ratti and A Calvo and C Moglia and M Brunetti and S Arcuti and R Capozzo and C Zecca and C Lunetta and S Penco and Natalia Riva and A Padovani and M Filosto and B Muller and Stuit, \{R J\} and I Blair and Kai Zhang and McCann, \{E P\} and Fifita, \{J A\} and Nicholson, \{G A\} and Rowe, \{D B\} and R Pamphlett and Kiernan, \{M C\} and J Grosskreutz and Witte, \{O W\} and T Ringer and T Prell and B Stubendorff and I Kurth and CA Hubner and PN Leigh and F Casale and A Chio and E Beghi and E Pupillo and R Tortelli and G Logroscino and J Powell and AC Ludolph and JH Weishaupt and W Robberecht and \{van Damme\}, P and L Franke and TH Pers and RH Brown and JD Glass and JE Landers and O Hardiman and PM Andersen and P Corcia and P Vourc'h and V Silani and NR Wray and PM Visscher and \{de Bakker\}, PIW and \{van Es\}, MA and RJ Pasterkamp and CM Lewis and G Breen and A Al-Chalabi and \{van den Berg\}, LH and JH Veldink",

year = "2016",

doi = "10.1038/ng.3622",

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volume = "48",

pages = "1043--1048",

journal = "Nature Genetics",

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van Rheenen, W, Shatunov, A, Dekker, AM, McLaughlin, RL, Diekstra, FP, Pulit, SL, van der Spek, RAA, Vosa, U, de Jong, S, Robinson, MR, Yang, J, Fogh, I, van Doormaal, PTC, Tazelaar, GHP, Koppers, M, Blokhuis, AM, Sproviero, W, Jones, AR, Kenna, KP, van Eijk, KR, Harschnitz, O, Schellevis, RD, Brands, WJ, Medic, J, Menelaou, A, Vajda, A, Ticozzi, N, Lin, K, Rogelj, B, Vrabec, K, Ravnik-Glavac, M, Koritnik, B, Zidar, J, Leonardis, L, Groselj, LD, Millecamps, S, Salachas, F, Meininger, V, Carvalho, M, Pinto, S, Mora, JS, Rojas-Garcia, R, Polak, M, Chandran, S, Colville, S, Swingler, R, Morrison, KE, Shaw, PJ, Hardy, J, Orrell, RW, Pittman, A, Sidle, K, Fratta, P, Malaspina, A, Topp, S, Petri, S, Abdulla, S, Drepper, C, Sendtner, M, Meyer, T, Ophoff, RA, Staats, KA, Wiedau-Pazos, M, Lomen-Hoerth, C, Van Deerlin, VM, Trojanowski, JQ, Elman, L, McCluskey, L, Basak, AN, Tunca, C, Hanizeiy, H, Parman, Y, Meitinger, T, Lichtner, P, Radivojkov-Blagojevic, M, Andres, CR, Maurel, C, Bensimon, G, Landwehrmeyer, B, Brice, A, Payan, CAM, Saker-Delye, S, Durr, A, Wood, NW, Tittmann, L, Lieb, W, Franke, A, Rietschel, M, Cichon, S, Nothen, MM, Amouyel, P, Tzourio, C, Dartigues, JF, Uitterlinden, A, Rivadeneira, F, Estrada Gil, K, Hofman, B, Curtis, C, Blauw, HM, van der Kooi, AJ, de Visser, M, Goris, A, Weber, M, Shaw, CE, Smith, BN, Pansarasa, O, Cereda, C, Del Bo, R, Comi, GP, D'Alfonso, S, Bertolin, C, Soraru, G, Mazzini, L, Pensato, V, Gellera, C, Tiloca, C, Ratti, A, Calvo, A, Moglia, C, Brunetti, M, Arcuti, S, Capozzo, R, Zecca, C, Lunetta, C, Penco, S, Riva, N, Padovani, A, Filosto, M, Muller, B, Stuit, RJ, Blair, I, Zhang, K, McCann, EP, Fifita, JA, Nicholson, GA, Rowe, DB, Pamphlett, R, Kiernan, MC, Grosskreutz, J, Witte, OW, Ringer, T, Prell, T, Stubendorff, B, Kurth, I, Hubner, CA, Leigh, PN, Casale, F, Chio, A, Beghi, E, Pupillo, E, Tortelli, R, Logroscino, G, Powell, J, Ludolph, AC, Weishaupt, JH, Robberecht, W, van Damme, P, Franke, L, Pers, TH, Brown, RH, Glass, JD, Landers, JE, Hardiman, O, Andersen, PM, Corcia, P, Vourc'h, P, Silani, V, Wray, NR, Visscher, PM, de Bakker, PIW, van Es, MA, Pasterkamp, RJ, Lewis, CM, Breen, G, Al-Chalabi, A, van den Berg, LH & Veldink, JH 2016, 'Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis', Nature Genetics, vol. 48, no. 9, pp. 1043-1048. https://doi.org/10.1038/ng.3622

TY - JOUR

T1 - Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

AU - van Rheenen, W

AU - Shatunov, A

AU - Dekker, AM

AU - McLaughlin, RL

AU - Diekstra, FP

AU - Pulit, SL

AU - van der Spek, R A A

AU - Vosa, U

AU - de Jong, S

AU - Robinson, MR

AU - Yang, Jiaqi

AU - Fogh, I

AU - van Doormaal, PTC

AU - Tazelaar, G H P

AU - Koppers, M

AU - Blokhuis, AM

AU - Sproviero, W

AU - Jones, A R

AU - Kenna, K P

AU - van Eijk, KR

AU - Harschnitz, O

AU - Schellevis, R D

AU - Brands, W J

AU - Medic, J

AU - Menelaou, A

AU - Vajda, A

AU - Ticozzi, N

AU - Lin, K

AU - Rogelj, B

AU - Vrabec, K

AU - Ravnik-Glavac, M

AU - Koritnik, B

AU - Zidar, J

AU - Leonardis, L

AU - Groselj, L D

AU - Millecamps, S

AU - Salachas, F

AU - Meininger, V

AU - Carvalho, M

AU - Pinto, S

AU - Mora, J S

AU - Rojas-Garcia, R

AU - Polak, M

AU - Chandran, S

AU - Colville, S

AU - Swingler, R

AU - Morrison, KE

AU - Shaw, PJ

AU - Hardy, J

AU - Orrell, RW

AU - Pittman, A

AU - Sidle, K

AU - Fratta, P

AU - Malaspina, A

AU - Topp, S

AU - Petri, S

AU - Abdulla, S

AU - Drepper, C

AU - Sendtner, M

AU - Meyer, T

AU - Ophoff, RA

AU - Staats, KA

AU - Wiedau-Pazos, M

AU - Lomen-Hoerth, C

AU - Van Deerlin, VM

AU - Trojanowski, JQ

AU - Elman, L

AU - McCluskey, L

AU - Basak, AN

AU - Tunca, C

AU - Hanizeiy, H

AU - Parman, Y

AU - Meitinger, T

AU - Lichtner, P

AU - Radivojkov-Blagojevic, M

AU - Andres, C R

AU - Maurel, C

AU - Bensimon, G

AU - Landwehrmeyer, B

AU - Brice, A

AU - Payan, C A M

AU - Saker-Delye, S

AU - Durr, A

AU - Wood, NW

AU - Tittmann, L

AU - Lieb, W

AU - Franke, A

AU - Rietschel, M

AU - Cichon, S

AU - Nothen, MM

AU - Amouyel, P

AU - Tzourio, C

AU - Dartigues, JF

AU - Uitterlinden, André

AU - Rivadeneira, Fernando

AU - Estrada Gil, Karol

AU - Hofman, Bert

AU - Curtis, C

AU - Blauw, HM

AU - van der Kooi, AJ

AU - de Visser, M

AU - Goris, A

AU - Weber, M

AU - Shaw, CE

AU - Smith, B N

AU - Pansarasa, O

AU - Cereda, C

AU - Del Bo, R

AU - Comi, G P

AU - D'Alfonso, S

AU - Bertolin, C

AU - Soraru, G

AU - Mazzini, L

AU - Pensato, V

AU - Gellera, C

AU - Tiloca, C

AU - Ratti, A

AU - Calvo, A

AU - Moglia, C

AU - Brunetti, M

AU - Arcuti, S

AU - Capozzo, R

AU - Zecca, C

AU - Lunetta, C

AU - Penco, S

AU - Riva, Natalia

AU - Padovani, A

AU - Filosto, M

AU - Muller, B

AU - Stuit, R J

AU - Blair, I

AU - Zhang, Kai

AU - McCann, E P

AU - Fifita, J A

AU - Nicholson, G A

AU - Rowe, D B

AU - Pamphlett, R

AU - Kiernan, M C

AU - Grosskreutz, J

AU - Witte, O W

AU - Ringer, T

AU - Prell, T

AU - Stubendorff, B

AU - Kurth, I

AU - Hubner, CA

AU - Leigh, PN

AU - Casale, F

AU - Chio, A

AU - Beghi, E

AU - Pupillo, E

AU - Tortelli, R

AU - Logroscino, G

AU - Powell, J

AU - Ludolph, AC

AU - Weishaupt, JH

AU - Robberecht, W

AU - van Damme, P

AU - Franke, L

AU - Pers, TH

AU - Brown, RH

AU - Glass, JD

AU - Landers, JE

AU - Hardiman, O

AU - Andersen, PM

AU - Corcia, P

AU - Vourc'h, P

AU - Silani, V

AU - Wray, NR

AU - Visscher, PM

AU - de Bakker, PIW

AU - van Es, MA

AU - Pasterkamp, RJ

AU - Lewis, CM

AU - Breen, G

AU - Al-Chalabi, A

AU - van den Berg, LH

AU - Veldink, JH

PY - 2016

Y1 - 2016

U2 - 10.1038/ng.3622

DO - 10.1038/ng.3622

M3 - Article

SN - 1061-4036

VL - 48

SP - 1043

EP - 1048

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -