Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

Milly Tedja; R Wojciechowski; PG Hysi; N Eriksson; NA Furlotte; Virginie Verhoeven; Adriana Iglesias Gonzalez; Magda Meester - Smoor; SW Tompson; Q Fan; AP Khawaja; CY (Ching-Yu) Cheng; R Hohn; K Yamashiro; A Wenocur; C Grazal; T Haller; A Metspalu; J Wedenoja; JB Jonas; YX Wang; J Xie; P Mitchell; PJ Foster; BEK Klein; R Klein; AD Paterson; SM Hosseini; RL Shah; C Williams; YY Teo; YC Tham; P Gupta; WT Zhao; Y Shi; WY Saw; ES Tai; XL Sim; JE Huffman; O Polasek; C Hayward; G Bencic; I Rudan; JF Wilson; PK Joshi; A Tsujikawa; F Matsuda; KN Whisenhunt; T Zeller; Peter van der Spek; Roxanna Haak; H Meijers-Heijboer; Elisa Leeuwen; SK Iyengar; JH Lass; Bert Hofman; Fernando Rivadeneira; André Uitterlinden; Hans Vingerling; T Lehtimaki; OT Raitakari; G Biino; MP Concas; TH Schwantes-An; RP Igo; G Cuellar-Partida; NG Martin; JE Craig; P Gharahkhani; KM Williams; A Nag; JS Rahi; PM Cumberland; C Delcourt; C Bellenguez; JS Ried; AA Bergen; T Meitinger; C Gieger; TY Wong; AW Hewitt; DA Mackey; CL Simpson; N Pfeiffer; O Parssinen; PN Baird; V Vitart; Najaf Amin; Cornelia Duijn; JE Bailey-Wilson; TL Young; SM Saw; D Stambolian; S Macgregor; JA Guggenheim; JY Tung; CJ Hammond; Caroline Klaver

doi:10.1038/s41588-018-0127-7

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

Milly Tedja, R Wojciechowski, PG Hysi, N Eriksson, NA Furlotte, Virginie Verhoeven, Adriana Iglesias Gonzalez, Magda Meester - Smoor, SW Tompson, Q Fan, AP Khawaja, CY (Ching-Yu) Cheng, R Hohn, K Yamashiro, A Wenocur, C Grazal, T Haller, A Metspalu, J Wedenoja, JB JonasYX Wang, J Xie, P Mitchell, PJ Foster, BEK Klein, R Klein, AD Paterson, SM Hosseini, RL Shah, C Williams, YY Teo, YC Tham, P Gupta, WT Zhao, Y Shi, WY Saw, ES Tai, XL Sim, JE Huffman, O Polasek, C Hayward, G Bencic, I Rudan, JF Wilson, PK Joshi, A Tsujikawa, F Matsuda, KN Whisenhunt, T Zeller, Peter van der Spek, Roxanna Haak, H Meijers-Heijboer, Elisa Leeuwen, SK Iyengar, JH Lass, Bert Hofman, Fernando Rivadeneira, André Uitterlinden, Hans Vingerling, T Lehtimaki, OT Raitakari, G Biino, MP Concas, TH Schwantes-An, RP Igo, G Cuellar-Partida, NG Martin, JE Craig, P Gharahkhani, KM Williams, A Nag, JS Rahi, PM Cumberland, C Delcourt, C Bellenguez, JS Ried, AA Bergen, T Meitinger, C Gieger, TY Wong, AW Hewitt, DA Mackey, CL Simpson, N Pfeiffer, O Parssinen, PN Baird, V Vitart, Najaf Amin, Cornelia Duijn, JE Bailey-Wilson, TL Young, SM Saw, D Stambolian, S Macgregor, JA Guggenheim, JY Tung, CJ Hammond, Caroline Klaver

Research output: Contribution to journal › Article › Academic › peer-review

254 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	834-848
Number of pages	15
Journal	Nature Genetics
Volume	50
Issue number	6
DOIs	https://doi.org/10.1038/s41588-018-0127-7
Publication status	Published - 2018

Research programs

EMC MM-01-39-09-A
EMC NIHES-01-64-02

Access to Document

10.1038/s41588-018-0127-7

http://hdl.handle.net/1765/107321

Cite this

Tedja, M., Wojciechowski, R., Hysi, PG., Eriksson, N., Furlotte, NA., Verhoeven, V., Iglesias Gonzalez, A., Meester - Smoor, M., Tompson, SW., Fan, Q., Khawaja, AP., Cheng, CY., Hohn, R., Yamashiro, K., Wenocur, A., Grazal, C., Haller, T., Metspalu, A., Wedenoja, J., ... Klaver, C. (2018). Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. Nature Genetics, 50(6), 834-848. https://doi.org/10.1038/s41588-018-0127-7

@article{7de3799650554957b7ca31347b0bce29,

title = "Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error",

author = "Milly Tedja and R Wojciechowski and PG Hysi and N Eriksson and NA Furlotte and Virginie Verhoeven and {Iglesias Gonzalez}, Adriana and {Meester - Smoor}, Magda and SW Tompson and Q Fan and AP Khawaja and Cheng, {CY (Ching-Yu)} and R Hohn and K Yamashiro and A Wenocur and C Grazal and T Haller and A Metspalu and J Wedenoja and JB Jonas and YX Wang and J Xie and P Mitchell and PJ Foster and BEK Klein and R Klein and AD Paterson and SM Hosseini and RL Shah and C Williams and YY Teo and YC Tham and P Gupta and WT Zhao and Y Shi and WY Saw and ES Tai and XL Sim and JE Huffman and O Polasek and C Hayward and G Bencic and I Rudan and JF Wilson and PK Joshi and A Tsujikawa and F Matsuda and KN Whisenhunt and T Zeller and {van der Spek}, Peter and Roxanna Haak and H Meijers-Heijboer and Elisa Leeuwen and SK Iyengar and JH Lass and Bert Hofman and Fernando Rivadeneira and Andr{\'e} Uitterlinden and Hans Vingerling and T Lehtimaki and OT Raitakari and G Biino and MP Concas and TH Schwantes-An and RP Igo and G Cuellar-Partida and NG Martin and JE Craig and P Gharahkhani and KM Williams and A Nag and JS Rahi and PM Cumberland and C Delcourt and C Bellenguez and JS Ried and AA Bergen and T Meitinger and C Gieger and TY Wong and AW Hewitt and DA Mackey and CL Simpson and N Pfeiffer and O Parssinen and PN Baird and V Vitart and Najaf Amin and Cornelia Duijn and JE Bailey-Wilson and TL Young and SM Saw and D Stambolian and S Macgregor and JA Guggenheim and JY Tung and CJ Hammond and Caroline Klaver",

year = "2018",

doi = "10.1038/s41588-018-0127-7",

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pages = "834--848",

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Tedja, M, Wojciechowski, R, Hysi, PG, Eriksson, N, Furlotte, NA, Verhoeven, V , Iglesias Gonzalez, A , Meester - Smoor, M, Tompson, SW, Fan, Q, Khawaja, AP, Cheng, CY, Hohn, R, Yamashiro, K, Wenocur, A, Grazal, C, Haller, T, Metspalu, A, Wedenoja, J, Jonas, JB, Wang, YX, Xie, J, Mitchell, P, Foster, PJ, Klein, BEK, Klein, R, Paterson, AD, Hosseini, SM, Shah, RL, Williams, C, Teo, YY, Tham, YC, Gupta, P, Zhao, WT, Shi, Y, Saw, WY, Tai, ES, Sim, XL, Huffman, JE, Polasek, O, Hayward, C, Bencic, G, Rudan, I, Wilson, JF, Joshi, PK, Tsujikawa, A, Matsuda, F, Whisenhunt, KN, Zeller, T, van der Spek, P, Haak, R, Meijers-Heijboer, H, Leeuwen, E, Iyengar, SK, Lass, JH, Hofman, B , Rivadeneira, F , Uitterlinden, A , Vingerling, H, Lehtimaki, T, Raitakari, OT, Biino, G, Concas, MP, Schwantes-An, TH, Igo, RP, Cuellar-Partida, G, Martin, NG, Craig, JE, Gharahkhani, P, Williams, KM, Nag, A, Rahi, JS, Cumberland, PM, Delcourt, C, Bellenguez, C, Ried, JS, Bergen, AA, Meitinger, T, Gieger, C, Wong, TY, Hewitt, AW, Mackey, DA, Simpson, CL, Pfeiffer, N, Parssinen, O, Baird, PN, Vitart, V, Amin, N, Duijn, C, Bailey-Wilson, JE, Young, TL, Saw, SM, Stambolian, D, Macgregor, S, Guggenheim, JA, Tung, JY, Hammond, CJ & Klaver, C 2018, 'Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error', Nature Genetics, vol. 50, no. 6, pp. 834-848. https://doi.org/10.1038/s41588-018-0127-7

TY - JOUR

T1 - Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

AU - Tedja, Milly

AU - Wojciechowski, R

AU - Hysi, PG

AU - Eriksson, N

AU - Furlotte, NA

AU - Verhoeven, Virginie

AU - Iglesias Gonzalez, Adriana

AU - Meester - Smoor, Magda

AU - Tompson, SW

AU - Fan, Q

AU - Khawaja, AP

AU - Cheng, CY (Ching-Yu)

AU - Hohn, R

AU - Yamashiro, K

AU - Wenocur, A

AU - Grazal, C

AU - Haller, T

AU - Metspalu, A

AU - Wedenoja, J

AU - Jonas, JB

AU - Wang, YX

AU - Xie, J

AU - Mitchell, P

AU - Foster, PJ

AU - Klein, BEK

AU - Klein, R

AU - Paterson, AD

AU - Hosseini, SM

AU - Shah, RL

AU - Williams, C

AU - Teo, YY

AU - Tham, YC

AU - Gupta, P

AU - Zhao, WT

AU - Shi, Y

AU - Saw, WY

AU - Tai, ES

AU - Sim, XL

AU - Huffman, JE

AU - Polasek, O

AU - Hayward, C

AU - Bencic, G

AU - Rudan, I

AU - Wilson, JF

AU - Joshi, PK

AU - Tsujikawa, A

AU - Matsuda, F

AU - Whisenhunt, KN

AU - Zeller, T

AU - van der Spek, Peter

AU - Haak, Roxanna

AU - Meijers-Heijboer, H

AU - Leeuwen, Elisa

AU - Iyengar, SK

AU - Lass, JH

AU - Hofman, Bert

AU - Rivadeneira, Fernando

AU - Uitterlinden, André

AU - Vingerling, Hans

AU - Lehtimaki, T

AU - Raitakari, OT

AU - Biino, G

AU - Concas, MP

AU - Schwantes-An, TH

AU - Igo, RP

AU - Cuellar-Partida, G

AU - Martin, NG

AU - Craig, JE

AU - Gharahkhani, P

AU - Williams, KM

AU - Nag, A

AU - Rahi, JS

AU - Cumberland, PM

AU - Delcourt, C

AU - Bellenguez, C

AU - Ried, JS

AU - Bergen, AA

AU - Meitinger, T

AU - Gieger, C

AU - Wong, TY

AU - Hewitt, AW

AU - Mackey, DA

AU - Simpson, CL

AU - Pfeiffer, N

AU - Parssinen, O

AU - Baird, PN

AU - Vitart, V

AU - Amin, Najaf

AU - Duijn, Cornelia

AU - Bailey-Wilson, JE

AU - Young, TL

AU - Saw, SM

AU - Stambolian, D

AU - Macgregor, S

AU - Guggenheim, JA

AU - Tung, JY

AU - Hammond, CJ

AU - Klaver, Caroline

PY - 2018

Y1 - 2018

U2 - 10.1038/s41588-018-0127-7

DO - 10.1038/s41588-018-0127-7

M3 - Article

C2 - 29808027

SN - 1061-4036

VL - 50

SP - 834

EP - 848

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -