Genome-wide association study confirms extant PD risk loci among the Dutch

J Simon-Sanchez; JJ van Hilten; B van de Warrenburg; B (Bart) Post; HW Berendse; S Arepalli; DG Hernandez; RMA de Bie; D Velseboer; H Scheffer; B Bloem; KD van Dijk; Fernando Rivadeneira; Bert Hofman; André Uitterlinden; P Rizzu; Z Bochdanovits; AB Singleton; P Heutink

doi:10.1038/ejhg.2010.254

Genome-wide association study confirms extant PD risk loci among the Dutch

J Simon-Sanchez, JJ van Hilten, B van de Warrenburg, B (Bart) Post, HW Berendse, S Arepalli, DG Hernandez, RMA de Bie, D Velseboer, H Scheffer, B Bloem, KD van Dijk, Fernando Rivadeneira, Bert Hofman, André Uitterlinden, P Rizzu, Z Bochdanovits, AB Singleton, P Heutink

Research output: Contribution to journal › Article › Academic › peer-review

155 Citations (Scopus)

Abstract

In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514 799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P=1.63x10(-5), OR=1.325 and BST1, rs12502586: P=1.63x10(-3), OR=1.337). Within SNCA, two independent signals in two different linkage disequilibrium (LD) blocks in the 3' and 5' ends of the gene were detected. Besides, post-hoc analysis confirmed GAK/DGKQ, HLA and MAPT as PD risk loci among the Dutch (GAK/DGKQ, rs2242235: P=1.22x10(-4), OR=1.51; HLA, rs4248166: P=4.39x10(-5), OR=1.36; and MAPT, rs3785880: P=1.9x10(-3), OR=1.19). European Journal of Human Genetics (2011) 19, 655-661; doi:10.1038/ejhg.2010.254; published online 19 January 2011

Original language	Undefined/Unknown
Pages (from-to)	655-661
Number of pages	7
Journal	European Journal of Human Genetics
Volume	19
Issue number	6
DOIs	https://doi.org/10.1038/ejhg.2010.254
Publication status	Published - 2011

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EMC MM-01-25-01
EMC MM-01-39-09-A
EMC NIHES-01-64-01

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ejhg.2010.254

http://hdl.handle.net/1765/26273

Cite this

Simon-Sanchez, J., van Hilten, JJ., van de Warrenburg, B., Post, B., Berendse, HW., Arepalli, S., Hernandez, DG., de Bie, RMA., Velseboer, D., Scheffer, H., Bloem, B., van Dijk, KD., Rivadeneira, F., Hofman, B., Uitterlinden, A., Rizzu, P., Bochdanovits, Z., Singleton, AB., & Heutink, P. (2011). Genome-wide association study confirms extant PD risk loci among the Dutch. European Journal of Human Genetics, 19(6), 655-661. https://doi.org/10.1038/ejhg.2010.254

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title = "Genome-wide association study confirms extant PD risk loci among the Dutch",

abstract = "In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514 799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P=1.63x10(-5), OR=1.325 and BST1, rs12502586: P=1.63x10(-3), OR=1.337). Within SNCA, two independent signals in two different linkage disequilibrium (LD) blocks in the 3' and 5' ends of the gene were detected. Besides, post-hoc analysis confirmed GAK/DGKQ, HLA and MAPT as PD risk loci among the Dutch (GAK/DGKQ, rs2242235: P=1.22x10(-4), OR=1.51; HLA, rs4248166: P=4.39x10(-5), OR=1.36; and MAPT, rs3785880: P=1.9x10(-3), OR=1.19). European Journal of Human Genetics (2011) 19, 655-661; doi:10.1038/ejhg.2010.254; published online 19 January 2011",

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Simon-Sanchez, J, van Hilten, JJ, van de Warrenburg, B, Post, B, Berendse, HW, Arepalli, S, Hernandez, DG, de Bie, RMA, Velseboer, D, Scheffer, H, Bloem, B, van Dijk, KD, Rivadeneira, F , Hofman, B , Uitterlinden, A, Rizzu, P, Bochdanovits, Z, Singleton, AB & Heutink, P 2011, 'Genome-wide association study confirms extant PD risk loci among the Dutch', European Journal of Human Genetics, vol. 19, no. 6, pp. 655-661. https://doi.org/10.1038/ejhg.2010.254

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AU - Simon-Sanchez, J

AU - van Hilten, JJ

AU - van de Warrenburg, B

AU - Post, B (Bart)

AU - Berendse, HW

AU - Arepalli, S

AU - Hernandez, DG

AU - de Bie, RMA

AU - Velseboer, D

AU - Scheffer, H

AU - Bloem, B

AU - van Dijk, KD

AU - Rivadeneira, Fernando

AU - Hofman, Bert

AU - Uitterlinden, André

AU - Rizzu, P

AU - Bochdanovits, Z

AU - Singleton, AB

AU - Heutink, P

PY - 2011

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N2 - In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514 799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P=1.63x10(-5), OR=1.325 and BST1, rs12502586: P=1.63x10(-3), OR=1.337). Within SNCA, two independent signals in two different linkage disequilibrium (LD) blocks in the 3' and 5' ends of the gene were detected. Besides, post-hoc analysis confirmed GAK/DGKQ, HLA and MAPT as PD risk loci among the Dutch (GAK/DGKQ, rs2242235: P=1.22x10(-4), OR=1.51; HLA, rs4248166: P=4.39x10(-5), OR=1.36; and MAPT, rs3785880: P=1.9x10(-3), OR=1.19). European Journal of Human Genetics (2011) 19, 655-661; doi:10.1038/ejhg.2010.254; published online 19 January 2011

AB - In view of the population-specific heterogeneity in reported genetic risk factors for Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a large sample of PD cases and controls from the Netherlands. After quality control (QC), a total of 514 799 SNPs genotyped in 772 PD cases and 2024 controls were included in our analyses. Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P=1.63x10(-5), OR=1.325 and BST1, rs12502586: P=1.63x10(-3), OR=1.337). Within SNCA, two independent signals in two different linkage disequilibrium (LD) blocks in the 3' and 5' ends of the gene were detected. Besides, post-hoc analysis confirmed GAK/DGKQ, HLA and MAPT as PD risk loci among the Dutch (GAK/DGKQ, rs2242235: P=1.22x10(-4), OR=1.51; HLA, rs4248166: P=4.39x10(-5), OR=1.36; and MAPT, rs3785880: P=1.9x10(-3), OR=1.19). European Journal of Human Genetics (2011) 19, 655-661; doi:10.1038/ejhg.2010.254; published online 19 January 2011

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DO - 10.1038/ejhg.2010.254

M3 - Article

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