Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

N Orr, A Lemnrau, R Cooke, O Fletcher, K Tomczyk, M Jones, N Johnson, CJ Lord, C Mitsopoulos, M Zvelebil, SS McDade, G Buck, C Blancher, AH Trainer, PA James, SE Bojesen, S Bokmand, H Nevanlinna, J Mattson, E FriedmanY Laitman, D Palli, G Masala, I Zanna, L Ottini, G Giannini, Antoinette Hollestelle, Ans van den Ouweland, S Novakovic, M Krajc, M Gago-Dominguez, JE Castelao, H Olsson, I Hedenfalk, DF Easton, PDP Pharoah, AM Dunning, DT Bishop, SL Neuhausen, L Steele, RS Houlston, M Garcia-Closas, A Ashworth, AJ Swerdlow

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Abstract

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).
Original languageUndefined/Unknown
Pages (from-to)1182-1184
Number of pages3
JournalNature Genetics
Volume44
Issue number11
DOIs
Publication statusPublished - 2012

Research programs

  • EMC MGC-02-96-01

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