Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

N Orr; A Lemnrau; R Cooke; O Fletcher; K Tomczyk; M Jones; N Johnson; CJ Lord; C Mitsopoulos; M Zvelebil; SS McDade; G Buck; C Blancher; AH Trainer; PA James; SE Bojesen; S Bokmand; H Nevanlinna; J Mattson; E Friedman; Y Laitman; D Palli; G Masala; I Zanna; L Ottini; G Giannini; Antoinette Hollestelle; Ans van den Ouweland; S Novakovic; M Krajc; M Gago-Dominguez; JE Castelao; H Olsson; I Hedenfalk; DF Easton; PDP Pharoah; AM Dunning; DT Bishop; SL Neuhausen; L Steele; RS Houlston; M Garcia-Closas; A Ashworth; AJ Swerdlow

doi:10.1038/ng.2417

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

N Orr
, A Lemnrau
, R Cooke
, O Fletcher
, K Tomczyk
, M Jones
, N Johnson
, CJ Lord
, C Mitsopoulos
, M Zvelebil
, SS McDade
, G Buck
, C Blancher
, AH Trainer
, PA James
, SE Bojesen
, S Bokmand
, H Nevanlinna
, J Mattson
, E Friedman

Y Laitman, D Palli, G Masala, I Zanna, L Ottini, G Giannini, Antoinette Hollestelle, Ans van den Ouweland, S Novakovic, M Krajc, M Gago-Dominguez, JE Castelao, H Olsson, I Hedenfalk, DF Easton, PDP Pharoah, AM Dunning, DT Bishop, SL Neuhausen, L Steele, RS Houlston, M Garcia-Closas, A Ashworth, AJ Swerdlow

Research output: Contribution to journal › Article › Academic › peer-review

94 Citations (Scopus)

Abstract

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).

Original language	Undefined/Unknown
Pages (from-to)	1182-1184
Number of pages	3
Journal	Nature Genetics
Volume	44
Issue number	11
DOIs	https://doi.org/10.1038/ng.2417
Publication status	Published - 2012

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EMC MGC-02-96-01

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Access to Document

10.1038/ng.2417

http://hdl.handle.net/1765/38813

Cite this

Orr, N., Lemnrau, A., Cooke, R., Fletcher, O., Tomczyk, K., Jones, M., Johnson, N., Lord, CJ., Mitsopoulos, C., Zvelebil, M., McDade, SS., Buck, G., Blancher, C., Trainer, AH., James, PA., Bojesen, SE., Bokmand, S., Nevanlinna, H., Mattson, J., ... Swerdlow, AJ. (2012). Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. Nature Genetics, 44(11), 1182-1184. https://doi.org/10.1038/ng.2417

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title = "Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk",

abstract = "We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).",

author = "N Orr and A Lemnrau and R Cooke and O Fletcher and K Tomczyk and M Jones and N Johnson and CJ Lord and C Mitsopoulos and M Zvelebil and SS McDade and G Buck and C Blancher and AH Trainer and PA James and SE Bojesen and S Bokmand and H Nevanlinna and J Mattson and E Friedman and Y Laitman and D Palli and G Masala and I Zanna and L Ottini and G Giannini and Antoinette Hollestelle and \{van den Ouweland\}, Ans and S Novakovic and M Krajc and M Gago-Dominguez and JE Castelao and H Olsson and I Hedenfalk and DF Easton and PDP Pharoah and AM Dunning and DT Bishop and SL Neuhausen and L Steele and RS Houlston and M Garcia-Closas and A Ashworth and AJ Swerdlow",

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Orr, N, Lemnrau, A, Cooke, R, Fletcher, O, Tomczyk, K, Jones, M, Johnson, N, Lord, CJ, Mitsopoulos, C, Zvelebil, M, McDade, SS, Buck, G, Blancher, C, Trainer, AH, James, PA, Bojesen, SE, Bokmand, S, Nevanlinna, H, Mattson, J, Friedman, E, Laitman, Y, Palli, D, Masala, G, Zanna, I, Ottini, L, Giannini, G, Hollestelle, A, van den Ouweland, A, Novakovic, S, Krajc, M, Gago-Dominguez, M, Castelao, JE, Olsson, H, Hedenfalk, I, Easton, DF, Pharoah, PDP, Dunning, AM, Bishop, DT, Neuhausen, SL, Steele, L, Houlston, RS, Garcia-Closas, M, Ashworth, A & Swerdlow, AJ 2012, 'Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk', Nature Genetics, vol. 44, no. 11, pp. 1182-1184. https://doi.org/10.1038/ng.2417

TY - JOUR

T1 - Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

AU - Orr, N

AU - Lemnrau, A

AU - Cooke, R

AU - Fletcher, O

AU - Tomczyk, K

AU - Jones, M

AU - Johnson, N

AU - Lord, CJ

AU - Mitsopoulos, C

AU - Zvelebil, M

AU - McDade, SS

AU - Buck, G

AU - Blancher, C

AU - Trainer, AH

AU - James, PA

AU - Bojesen, SE

AU - Bokmand, S

AU - Nevanlinna, H

AU - Mattson, J

AU - Friedman, E

AU - Laitman, Y

AU - Palli, D

AU - Masala, G

AU - Zanna, I

AU - Ottini, L

AU - Giannini, G

AU - Hollestelle, Antoinette

AU - van den Ouweland, Ans

AU - Novakovic, S

AU - Krajc, M

AU - Gago-Dominguez, M

AU - Castelao, JE

AU - Olsson, H

AU - Hedenfalk, I

AU - Easton, DF

AU - Pharoah, PDP

AU - Dunning, AM

AU - Bishop, DT

AU - Neuhausen, SL

AU - Steele, L

AU - Houlston, RS

AU - Garcia-Closas, M

AU - Ashworth, A

AU - Swerdlow, AJ

PY - 2012

Y1 - 2012

N2 - We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).

AB - We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 x 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 x 10(-15); OR = 1.50).

U2 - 10.1038/ng.2417

DO - 10.1038/ng.2417

M3 - Article

C2 - 23001122

SN - 1061-4036

VL - 44

SP - 1182

EP - 1184

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -