Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate

E Mangold, KU Ludwig, S Birnbaum, C Baluardo, M Ferrian, S Herms, H Reutter, NA de Assis, T Al Chawa, M Mattheisen, M Steffens, S Barth, N Kluck, A Paul, J Becker, C Lauster, G Schmidt, B Braumann, M Scheer, RH ReichA Hemprich, S Potzsch, B Blaumeiser, S Moebus, M Krawczak, S Schreiber, T Meitinger, HE Wichmann, Régine Steegers - Theunissen, FJ Kramer, S Cichon, P Propping, TF Wienker, M Knapp, M Rubini, PA Mossey, P Hoffmann, MM Nothen

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Abstract

We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).
Original languageUndefined/Unknown
Pages (from-to)24-26
Number of pages3
JournalNature Genetics
Volume42
Issue number1
DOIs
Publication statusPublished - 2010

Research programs

  • EMC MGC-02-52-01-A
  • EMC MGC-02-96-01
  • EMC NIHES-01-64-02

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