Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate

E Mangold; KU Ludwig; S Birnbaum; C Baluardo; M Ferrian; S Herms; H Reutter; NA de Assis; T Al Chawa; M Mattheisen; M Steffens; S Barth; N Kluck; A Paul; J Becker; C Lauster; G Schmidt; B Braumann; M Scheer; RH Reich; A Hemprich; S Potzsch; B Blaumeiser; S Moebus; M Krawczak; S Schreiber; T Meitinger; HE Wichmann; Régine Steegers - Theunissen; FJ Kramer; S Cichon; P Propping; TF Wienker; M Knapp; M Rubini; PA Mossey; P Hoffmann; MM Nothen

doi:10.1038/ng.506

Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate

E Mangold, KU Ludwig, S Birnbaum, C Baluardo, M Ferrian, S Herms, H Reutter, NA de Assis, T Al Chawa, M Mattheisen, M Steffens, S Barth, N Kluck, A Paul, J Becker, C Lauster, G Schmidt, B Braumann, M Scheer, RH ReichA Hemprich, S Potzsch, B Blaumeiser, S Moebus, M Krawczak, S Schreiber, T Meitinger, HE Wichmann, Régine Steegers - Theunissen, FJ Kramer, S Cichon, P Propping, TF Wienker, M Knapp, M Rubini, PA Mossey, P Hoffmann, MM Nothen

Obstetrics & Gynecology

Research output: Contribution to journal › Article › Academic › peer-review

343 Citations (Scopus)

Abstract

We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).

Original language	Undefined/Unknown
Pages (from-to)	24-26
Number of pages	3
Journal	Nature Genetics
Volume	42
Issue number	1
DOIs	https://doi.org/10.1038/ng.506
Publication status	Published - 2010

Research programs

EMC MGC-02-52-01-A
EMC MGC-02-96-01
EMC NIHES-01-64-02

Access to Document

10.1038/ng.506

http://hdl.handle.net/1765/27061

Cite this

Mangold, E., Ludwig, KU., Birnbaum, S., Baluardo, C., Ferrian, M., Herms, S., Reutter, H., de Assis, NA., Al Chawa, T., Mattheisen, M., Steffens, M., Barth, S., Kluck, N., Paul, A., Becker, J., Lauster, C., Schmidt, G., Braumann, B., Scheer, M., ... Nothen, MM. (2010). Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. Nature Genetics, 42(1), 24-26. https://doi.org/10.1038/ng.506

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title = "Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate",

abstract = "We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).",

author = "E Mangold and KU Ludwig and S Birnbaum and C Baluardo and M Ferrian and S Herms and H Reutter and {de Assis}, NA and {Al Chawa}, T and M Mattheisen and M Steffens and S Barth and N Kluck and A Paul and J Becker and C Lauster and G Schmidt and B Braumann and M Scheer and RH Reich and A Hemprich and S Potzsch and B Blaumeiser and S Moebus and M Krawczak and S Schreiber and T Meitinger and HE Wichmann and {Steegers - Theunissen}, R{\'e}gine and FJ Kramer and S Cichon and P Propping and TF Wienker and M Knapp and M Rubini and PA Mossey and P Hoffmann and MM Nothen",

year = "2010",

doi = "10.1038/ng.506",

language = "Undefined/Unknown",

volume = "42",

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journal = "Nature Genetics",

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Mangold, E, Ludwig, KU, Birnbaum, S, Baluardo, C, Ferrian, M, Herms, S, Reutter, H, de Assis, NA, Al Chawa, T, Mattheisen, M, Steffens, M, Barth, S, Kluck, N, Paul, A, Becker, J, Lauster, C, Schmidt, G, Braumann, B, Scheer, M, Reich, RH, Hemprich, A, Potzsch, S, Blaumeiser, B, Moebus, S, Krawczak, M, Schreiber, S, Meitinger, T, Wichmann, HE, Steegers - Theunissen, R, Kramer, FJ, Cichon, S, Propping, P, Wienker, TF, Knapp, M, Rubini, M, Mossey, PA, Hoffmann, P & Nothen, MM 2010, 'Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate', Nature Genetics, vol. 42, no. 1, pp. 24-26. https://doi.org/10.1038/ng.506

TY - JOUR

T1 - Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate

AU - Mangold, E

AU - Ludwig, KU

AU - Birnbaum, S

AU - Baluardo, C

AU - Ferrian, M

AU - Herms, S

AU - Reutter, H

AU - de Assis, NA

AU - Al Chawa, T

AU - Mattheisen, M

AU - Steffens, M

AU - Barth, S

AU - Kluck, N

AU - Paul, A

AU - Becker, J

AU - Lauster, C

AU - Schmidt, G

AU - Braumann, B

AU - Scheer, M

AU - Reich, RH

AU - Hemprich, A

AU - Potzsch, S

AU - Blaumeiser, B

AU - Moebus, S

AU - Krawczak, M

AU - Schreiber, S

AU - Meitinger, T

AU - Wichmann, HE

AU - Steegers - Theunissen, Régine

AU - Kramer, FJ

AU - Cichon, S

AU - Propping, P

AU - Wienker, TF

AU - Knapp, M

AU - Rubini, M

AU - Mossey, PA

AU - Hoffmann, P

AU - Nothen, MM

PY - 2010

Y1 - 2010

N2 - We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).

AB - We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).

U2 - 10.1038/ng.506

DO - 10.1038/ng.506

M3 - Article

C2 - 20023658

SN - 1061-4036

VL - 42

SP - 24

EP - 26

JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -