Genome-wide association study of blood pressure and hypertension

D Levy; GB Ehret; K Rice; Germaine Verwoert; LJ (Lenore) Launer; Abbas Dehghan; NL Glazer; AC Morrison; AD Johnson; T Aspelund; Yuriy Aulchenko; T Lumley; A Kottgen; RS Vasan; Fernando Rivadeneira; G Eiriksdottir; XQ Guo; DE Arking; GF Mitchell; F.U.S. Mattace Raso; AV Smith; K Taylor; RB Scharpf; SJ Hwang; E.J.G. Sijbrands; JC Bis; TB Harris; SK Ganesh; CJ O'Donnell; Bert Hofman; JI Rotter; J Coresh; EJ Benjamin; André Uitterlinden; G Heiss; CS Fox; JCM Witteman; E Boerwinkle; TJ Wang; V Gudnason; MG Larson; A Chakravarti; BM Psaty; Cornelia Duijn

doi:10.1038/ng.384

Genome-wide association study of blood pressure and hypertension

D Levy
, GB Ehret
, K Rice
, Germaine Verwoert
, LJ (Lenore) Launer
, Abbas Dehghan
, NL Glazer
, AC Morrison
, AD Johnson
, T Aspelund
, Yuriy Aulchenko
, T Lumley
, A Kottgen
, RS Vasan
, Fernando Rivadeneira
, G Eiriksdottir
, XQ Guo
, DE Arking
, GF Mitchell
, F.U.S. Mattace Raso

AV Smith, K Taylor, RB Scharpf, SJ Hwang, E.J.G. Sijbrands, JC Bis, TB Harris, SK Ganesh, CJ O'Donnell, Bert Hofman, JI Rotter, J Coresh, EJ Benjamin, André Uitterlinden, G Heiss, CS Fox, JCM Witteman, E Boerwinkle, TJ Wang, V Gudnason, MG Larson, A Chakravarti, BM Psaty, Cornelia Duijn

External organisation

Research output: Contribution to journal › Article › Academic › peer-review

1204 Citations (Scopus)

Abstract

Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 x 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 x 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.

Original language	Undefined/Unknown
Pages (from-to)	677-687
Number of pages	11
Journal	Nature Genetics
Volume	41
Issue number	6
DOIs	https://doi.org/10.1038/ng.384
Publication status	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research programs

EMC COEUR-09
EMC MM-01-39-02
EMC NIHES-01-64-01
EMC OR-01-39-08

Access to Document

10.1038/ng.384

http://hdl.handle.net/1765/24577

Cite this

Levy, D., Ehret, GB., Rice, K., Verwoert, G., Launer, LJ., Dehghan, A., Glazer, NL., Morrison, AC., Johnson, AD., Aspelund, T., Aulchenko, Y., Lumley, T., Kottgen, A., Vasan, RS., Rivadeneira, F., Eiriksdottir, G., Guo, XQ., Arking, DE., Mitchell, GF., ... Duijn, C. (2009). Genome-wide association study of blood pressure and hypertension. Nature Genetics, 41(6), 677-687. https://doi.org/10.1038/ng.384

@article{25722944009b4174ab7dd320f8fabae7,

title = "Genome-wide association study of blood pressure and hypertension",

abstract = "Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 x 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 x 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.",

author = "D Levy and GB Ehret and K Rice and Germaine Verwoert and Launer, \{LJ (Lenore)\} and Abbas Dehghan and NL Glazer and AC Morrison and AD Johnson and T Aspelund and Yuriy Aulchenko and T Lumley and A Kottgen and RS Vasan and Fernando Rivadeneira and G Eiriksdottir and XQ Guo and DE Arking and GF Mitchell and \{Mattace Raso\}, F.U.S. and AV Smith and K Taylor and RB Scharpf and SJ Hwang and E.J.G. Sijbrands and JC Bis and TB Harris and SK Ganesh and CJ O'Donnell and Bert Hofman and JI Rotter and J Coresh and EJ Benjamin and Andr{\'e} Uitterlinden and G Heiss and CS Fox and JCM Witteman and E Boerwinkle and TJ Wang and V Gudnason and MG Larson and A Chakravarti and BM Psaty and Cornelia Duijn",

year = "2009",

doi = "10.1038/ng.384",

language = "Undefined/Unknown",

volume = "41",

pages = "677--687",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "6",

}

Levy, D, Ehret, GB, Rice, K, Verwoert, G, Launer, LJ, Dehghan, A, Glazer, NL, Morrison, AC, Johnson, AD, Aspelund, T, Aulchenko, Y, Lumley, T, Kottgen, A, Vasan, RS, Rivadeneira, F, Eiriksdottir, G, Guo, XQ, Arking, DE, Mitchell, GF, Mattace Raso, FUS, Smith, AV, Taylor, K, Scharpf, RB, Hwang, SJ, Sijbrands, EJG, Bis, JC, Harris, TB, Ganesh, SK, O'Donnell, CJ, Hofman, B, Rotter, JI, Coresh, J, Benjamin, EJ, Uitterlinden, A, Heiss, G, Fox, CS, Witteman, JCM, Boerwinkle, E, Wang, TJ, Gudnason, V, Larson, MG, Chakravarti, A, Psaty, BM & Duijn, C 2009, 'Genome-wide association study of blood pressure and hypertension', Nature Genetics, vol. 41, no. 6, pp. 677-687. https://doi.org/10.1038/ng.384

TY - JOUR

T1 - Genome-wide association study of blood pressure and hypertension

AU - Levy, D

AU - Ehret, GB

AU - Rice, K

AU - Verwoert, Germaine

AU - Launer, LJ (Lenore)

AU - Dehghan, Abbas

AU - Glazer, NL

AU - Morrison, AC

AU - Johnson, AD

AU - Aspelund, T

AU - Aulchenko, Yuriy

AU - Lumley, T

AU - Kottgen, A

AU - Vasan, RS

AU - Rivadeneira, Fernando

AU - Eiriksdottir, G

AU - Guo, XQ

AU - Arking, DE

AU - Mitchell, GF

AU - Mattace Raso, F.U.S.

AU - Smith, AV

AU - Taylor, K

AU - Scharpf, RB

AU - Hwang, SJ

AU - Sijbrands, E.J.G.

AU - Bis, JC

AU - Harris, TB

AU - Ganesh, SK

AU - O'Donnell, CJ

AU - Hofman, Bert

AU - Rotter, JI

AU - Coresh, J

AU - Benjamin, EJ

AU - Uitterlinden, André

AU - Heiss, G

AU - Fox, CS

AU - Witteman, JCM

AU - Boerwinkle, E

AU - Wang, TJ

AU - Gudnason, V

AU - Larson, MG

AU - Chakravarti, A

AU - Psaty, BM

AU - Duijn, Cornelia

PY - 2009

Y1 - 2009

N2 - Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 x 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 x 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.

AB - Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 x 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 x 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.

U2 - 10.1038/ng.384

DO - 10.1038/ng.384

M3 - Article

C2 - 19430479

SN - 1061-4036

VL - 41

SP - 677

EP - 687

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -