Genome-wide Association Study of Smoking Initiation and Current Smoking

JM Vink; AB Smit; EJC de Geus; P Sullivan; G Willemsen; JJ (Jouke Jan) Hottenga; JH Smit; WJ Hoogendijk; FG Zitman; L Peltonen; J Kaprio; NL Pedersen; PK Magnusson; TD Spector; KO Kyvik; KI Morleyis; AC Heath; NG Martin; RGJ Westendorp; PE (Eline) Slagboom; Henning Tiemeier; Bert Hofman; André Uitterlinden; YS Aulchenko; Najaf Amin; Cornelia Duijn; BW Penninx; DI Boomsma

doi:10.1016/j.ajhg.2009.02.001

Genome-wide Association Study of Smoking Initiation and Current Smoking

JM Vink, AB Smit, EJC de Geus, P Sullivan, G Willemsen, JJ (Jouke Jan) Hottenga, JH Smit, WJ Hoogendijk, FG Zitman, L Peltonen, J Kaprio, NL Pedersen, PK Magnusson, TD Spector, KO Kyvik, KI Morleyis, AC Heath, NG Martin, RGJ Westendorp, PE (Eline) SlagboomHenning Tiemeier, Bert Hofman, André Uitterlinden, YS Aulchenko, Najaf Amin, Cornelia Duijn, BW Penninx, DI Boomsma

Research output: Contribution to journal › Article › Academic › peer-review

112 Citations (Scopus)

Abstract

For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples(n - 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

Original language	Undefined/Unknown
Pages (from-to)	367-379
Number of pages	13
Journal	American Journal of Human Genetics
Volume	84
Issue number	3
DOIs	https://doi.org/10.1016/j.ajhg.2009.02.001
Publication status	Published - 2009

Research programs

EMC NIHES-01-64-01

Access to Document

10.1016/j.ajhg.2009.02.001

http://hdl.handle.net/1765/24250

Cite this

Vink, JM., Smit, AB., de Geus, EJC., Sullivan, P., Willemsen, G., Hottenga, JJ., Smit, JH., Hoogendijk, WJ., Zitman, FG., Peltonen, L., Kaprio, J., Pedersen, NL., Magnusson, PK., Spector, TD., Kyvik, KO., Morleyis, KI., Heath, AC., Martin, NG., Westendorp, RGJ., ... Boomsma, DI. (2009). Genome-wide Association Study of Smoking Initiation and Current Smoking. American Journal of Human Genetics, 84(3), 367-379. https://doi.org/10.1016/j.ajhg.2009.02.001

@article{99a87eb775894234873ffea4fb245ac5,

title = "Genome-wide Association Study of Smoking Initiation and Current Smoking",

abstract = "For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples(n - 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.",

author = "JM Vink and AB Smit and {de Geus}, EJC and P Sullivan and G Willemsen and Hottenga, {JJ (Jouke Jan)} and JH Smit and WJ Hoogendijk and FG Zitman and L Peltonen and J Kaprio and NL Pedersen and PK Magnusson and TD Spector and KO Kyvik and KI Morleyis and AC Heath and NG Martin and RGJ Westendorp and Slagboom, {PE (Eline)} and Henning Tiemeier and Bert Hofman and Andr{\'e} Uitterlinden and YS Aulchenko and Najaf Amin and Cornelia Duijn and BW Penninx and DI Boomsma",

year = "2009",

doi = "10.1016/j.ajhg.2009.02.001",

language = "Undefined/Unknown",

volume = "84",

pages = "367--379",

journal = "American Journal of Human Genetics",

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Vink, JM, Smit, AB, de Geus, EJC, Sullivan, P, Willemsen, G, Hottenga, JJ, Smit, JH, Hoogendijk, WJ, Zitman, FG, Peltonen, L, Kaprio, J, Pedersen, NL, Magnusson, PK, Spector, TD, Kyvik, KO, Morleyis, KI, Heath, AC, Martin, NG, Westendorp, RGJ, Slagboom, PE, Tiemeier, H, Hofman, B , Uitterlinden, A, Aulchenko, YS, Amin, N, Duijn, C, Penninx, BW & Boomsma, DI 2009, 'Genome-wide Association Study of Smoking Initiation and Current Smoking', American Journal of Human Genetics, vol. 84, no. 3, pp. 367-379. https://doi.org/10.1016/j.ajhg.2009.02.001

TY - JOUR

T1 - Genome-wide Association Study of Smoking Initiation and Current Smoking

AU - Vink, JM

AU - Smit, AB

AU - de Geus, EJC

AU - Sullivan, P

AU - Willemsen, G

AU - Hottenga, JJ (Jouke Jan)

AU - Smit, JH

AU - Hoogendijk, WJ

AU - Zitman, FG

AU - Peltonen, L

AU - Kaprio, J

AU - Pedersen, NL

AU - Magnusson, PK

AU - Spector, TD

AU - Kyvik, KO

AU - Morleyis, KI

AU - Heath, AC

AU - Martin, NG

AU - Westendorp, RGJ

AU - Slagboom, PE (Eline)

AU - Tiemeier, Henning

AU - Hofman, Bert

AU - Uitterlinden, André

AU - Aulchenko, YS

AU - Amin, Najaf

AU - Duijn, Cornelia

AU - Penninx, BW

AU - Boomsma, DI

PY - 2009

Y1 - 2009

N2 - For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples(n - 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

AB - For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples(n - 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

U2 - 10.1016/j.ajhg.2009.02.001

DO - 10.1016/j.ajhg.2009.02.001

M3 - Article

C2 - 19268276

SN - 0002-9297

VL - 84

SP - 367

EP - 379

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 3

ER -