Genome-Wide Association Study of Vascular Dementia

Elisabeth Schrijvers; B Schurmann; Peter Koudstaal; H van den Bussche; Cornelia Duijn; F Hentschel; R Heun; Bert Hofman; F Jessen; H Kolsch; J Kornhuber; O Peters; Fernando Rivadeneira; E Ruether; André Uitterlinden; S Riedel-Heller; M Dichgans; J Wiltfang; W Maier; Monique Breteler; Arfan Ikram

doi:10.1161/STROKEAHA.111.628768

Genome-Wide Association Study of Vascular Dementia

Elisabeth Schrijvers, B Schurmann, Peter Koudstaal, H van den Bussche, Cornelia Duijn, F Hentschel, R Heun, Bert Hofman, F Jessen, H Kolsch, J Kornhuber, O Peters, Fernando Rivadeneira, E Ruether, André Uitterlinden, S Riedel-Heller, M Dichgans, J Wiltfang, W Maier, Monique BretelerArfan Ikram

Research output: Contribution to journal › Article › Academic › peer-review

54 Citations (Scopus)

Abstract

Background and Purpose-Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia. Methods-We performed a genome-wide association study in the Rotterdam Study, a large prospective population-based cohort study in the Netherlands. We sought to replicate genome-wide significant loci in 2 independent replication samples. Results-In the discovery analysis of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3 +/- 3.2 years. We showed genome-wide significance for rs12007229, which is located on the X chromosome near the androgen receptor gene (OR, 3.7; 95% CI, 2.3-5.8, per copy of the minor allele; P=1.3 X 10(-8)). This association was further confirmed in 2 independent populations (probability value of combined replication samples=0.024). Conclusions-Our study shows a novel genetic locus for vascular dementia on the X chromosome. Further replication of this finding is required. (Stroke. 2012;43:315-319.)

Original language	Undefined/Unknown
Pages (from-to)	315-319
Number of pages	5
Journal	Stroke
Volume	43
Issue number	2
DOIs	https://doi.org/10.1161/STROKEAHA.111.628768
Publication status	Published - 2012

Research programs

EMC COEUR-09
EMC MM-01-39-09-A
EMC NIHES-01-64-01
EMC NIHES-01-64-02
EMC NIHES-03-30-01

Access to Document

10.1161/STROKEAHA.111.628768

http://hdl.handle.net/1765/38298

Cite this

Schrijvers, E., Schurmann, B., Koudstaal, P., van den Bussche, H., Duijn, C., Hentschel, F., Heun, R., Hofman, B., Jessen, F., Kolsch, H., Kornhuber, J., Peters, O., Rivadeneira, F., Ruether, E., Uitterlinden, A., Riedel-Heller, S., Dichgans, M., Wiltfang, J., Maier, W., ... Ikram, A. (2012). Genome-Wide Association Study of Vascular Dementia. Stroke, 43(2), 315-319. https://doi.org/10.1161/STROKEAHA.111.628768

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abstract = "Background and Purpose-Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia. Methods-We performed a genome-wide association study in the Rotterdam Study, a large prospective population-based cohort study in the Netherlands. We sought to replicate genome-wide significant loci in 2 independent replication samples. Results-In the discovery analysis of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3 +/- 3.2 years. We showed genome-wide significance for rs12007229, which is located on the X chromosome near the androgen receptor gene (OR, 3.7; 95% CI, 2.3-5.8, per copy of the minor allele; P=1.3 X 10(-8)). This association was further confirmed in 2 independent populations (probability value of combined replication samples=0.024). Conclusions-Our study shows a novel genetic locus for vascular dementia on the X chromosome. Further replication of this finding is required. (Stroke. 2012;43:315-319.)",

author = "Elisabeth Schrijvers and B Schurmann and Peter Koudstaal and {van den Bussche}, H and Cornelia Duijn and F Hentschel and R Heun and Bert Hofman and F Jessen and H Kolsch and J Kornhuber and O Peters and Fernando Rivadeneira and E Ruether and Andr{\'e} Uitterlinden and S Riedel-Heller and M Dichgans and J Wiltfang and W Maier and Monique Breteler and Arfan Ikram",

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doi = "10.1161/STROKEAHA.111.628768",

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Schrijvers, E, Schurmann, B, Koudstaal, P, van den Bussche, H, Duijn, C, Hentschel, F, Heun, R, Hofman, B, Jessen, F, Kolsch, H, Kornhuber, J, Peters, O, Rivadeneira, F, Ruether, E, Uitterlinden, A, Riedel-Heller, S, Dichgans, M, Wiltfang, J, Maier, W, Breteler, M & Ikram, A 2012, 'Genome-Wide Association Study of Vascular Dementia', Stroke, vol. 43, no. 2, pp. 315-319. https://doi.org/10.1161/STROKEAHA.111.628768

TY - JOUR

T1 - Genome-Wide Association Study of Vascular Dementia

AU - Schrijvers, Elisabeth

AU - Schurmann, B

AU - Koudstaal, Peter

AU - van den Bussche, H

AU - Duijn, Cornelia

AU - Hentschel, F

AU - Heun, R

AU - Hofman, Bert

AU - Jessen, F

AU - Kolsch, H

AU - Kornhuber, J

AU - Peters, O

AU - Rivadeneira, Fernando

AU - Ruether, E

AU - Uitterlinden, André

AU - Riedel-Heller, S

AU - Dichgans, M

AU - Wiltfang, J

AU - Maier, W

AU - Breteler, Monique

AU - Ikram, Arfan

PY - 2012

Y1 - 2012

N2 - Background and Purpose-Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia. Methods-We performed a genome-wide association study in the Rotterdam Study, a large prospective population-based cohort study in the Netherlands. We sought to replicate genome-wide significant loci in 2 independent replication samples. Results-In the discovery analysis of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3 +/- 3.2 years. We showed genome-wide significance for rs12007229, which is located on the X chromosome near the androgen receptor gene (OR, 3.7; 95% CI, 2.3-5.8, per copy of the minor allele; P=1.3 X 10(-8)). This association was further confirmed in 2 independent populations (probability value of combined replication samples=0.024). Conclusions-Our study shows a novel genetic locus for vascular dementia on the X chromosome. Further replication of this finding is required. (Stroke. 2012;43:315-319.)

AB - Background and Purpose-Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia. Methods-We performed a genome-wide association study in the Rotterdam Study, a large prospective population-based cohort study in the Netherlands. We sought to replicate genome-wide significant loci in 2 independent replication samples. Results-In the discovery analysis of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3 +/- 3.2 years. We showed genome-wide significance for rs12007229, which is located on the X chromosome near the androgen receptor gene (OR, 3.7; 95% CI, 2.3-5.8, per copy of the minor allele; P=1.3 X 10(-8)). This association was further confirmed in 2 independent populations (probability value of combined replication samples=0.024). Conclusions-Our study shows a novel genetic locus for vascular dementia on the X chromosome. Further replication of this finding is required. (Stroke. 2012;43:315-319.)

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DO - 10.1161/STROKEAHA.111.628768

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SN - 0039-2499

VL - 43

SP - 315

EP - 319

JO - Stroke

JF - Stroke

IS - 2

ER -