Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

Mélanie Guirette; Jessie Lan; Nicola McKeown; Michael R Brown; Han Chen; Paul S DE Vries; Hyunju Kim; Casey M Rebholz; Alanna C Morrison; Traci M Bartz; Amanda M Fretts; Xiuqing Guo; Rozenn N Lemaitre; Ching-Ti Liu; Raymond Noordam; Renée DE Mutsert; Frits R Rosendaal; Carol A Wang; Lawrence Beilin; Trevor A Mori; Wendy H Oddy; Craig E Pennell; Jin Fang Chai; Clare Whitton; Rob M VAN Dam; Jianjun Liu; E Shyong Tai; Xueling Sim; Marian L Neuhouser; Charles Kooperberg; Lesley Tinker; Nora Franceschini; Tianxiao Huan; Thomas W Winkler; Amy R Bentley; W James Gauderman; Luc Heerkens; Toshiko Tanaka; Jeroen van Rooij; Patricia B Munroe; Helen R Warren; Trudy Voortman; Honglei Chen; D C Rao; Daniel Levy; Jiantao Ma

doi:10.1101/2023.11.10.23298402

Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

Mélanie Guirette
, Jessie Lan
, Nicola McKeown
, Michael R Brown
, Han Chen
, Paul S DE Vries
, Hyunju Kim
, Casey M Rebholz
, Alanna C Morrison
, Traci M Bartz
, Amanda M Fretts
, Xiuqing Guo
, Rozenn N Lemaitre
, Ching-Ti Liu
, Raymond Noordam
, Renée DE Mutsert
, Frits R Rosendaal
, Carol A Wang
, Lawrence Beilin
, Trevor A Mori

Wendy H Oddy, Craig E Pennell, Jin Fang Chai, Clare Whitton, Rob M VAN Dam, Jianjun Liu, E Shyong Tai, Xueling Sim, Marian L Neuhouser, Charles Kooperberg, Lesley Tinker, Nora Franceschini, Tianxiao Huan, Thomas W Winkler, Amy R Bentley, W James Gauderman, Luc Heerkens, Toshiko Tanaka, Jeroen van Rooij, Patricia B Munroe, Helen R Warren, Trudy Voortman, Honglei Chen, D C Rao, Daniel Levy, Jiantao Ma

Tufts University
Boston University
University of Texas Health Science Center at Houston
University of Washington
Johns Hopkins Bloomberg School of Public Health
The Lundquist Institute for Biomedical Innovation
Boston University School of Public Health
Leiden University Medical Centre
University of Newcastle
University of Western Australia
University of Tasmania
Curtin University
Genome Institute of Singapore
Fred Hutchinson Cancer Research Center
University of North Carolina at Chapel Hill
Framingham Heart Study and Population Sciences Branch
University of Regensburg
National Institutes of Health
University of Southern California
Queen Mary University of London
Michigan State University
University of Washington School of Medicine

Research output: Working paper › Preprint › Academic

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Abstract

OBJECTIVE: We examined interactions between genotype and a Dietary Approaches to Stop Hypertension (DASH) diet score in relation to systolic blood pressure (SBP).

METHODS: We analyzed up to 9,420,585 biallelic imputed single nucleotide polymorphisms (SNPs) in up to 127,282 individuals of six population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (CHARGE; n=35,660) and UK Biobank (n=91,622) and performed European population-specific and cross-population meta-analyses.

RESULTS: We identified three loci in European-specific analyses and an additional four loci in cross-population analyses at P for interaction < 5e-8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency = 0.03) and the DASH diet score (P for interaction = 4e-8; P for heterogeneity = 0.35) in European population, where the interaction effect size was 0.42±0.09 mm Hg (P for interaction = 9.4e-7) and 0.20±0.06 mm Hg (P for interaction = 0.001) in CHARGE and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with cis-expression quantitative trait loci (eQTL) variants (P = 4e-273) and cis-DNA methylation quantitative trait loci (mQTL) variants (P = 1e-300). While the closest gene for rs117878928 is MTHFS, the highest narrow sense heritability accounted by SNPs potentially interacting with the DASH diet score in this locus was for gene ST20 at 15q25.1.

CONCLUSION: We demonstrated gene-DASH diet score interaction effects on SBP in several loci. Studies with larger diverse populations are needed to validate our findings.

Original language	English
DOIs	https://doi.org/10.1101/2023.11.10.23298402
Publication status	Published - 12 Nov 2023

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Series	medRxiv : the preprint server for health sciences

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10.1101/2023.11.10.23298402Licence: CC BY-NC-ND

2023.11.10.23298402v1.fullFinal published version, 1.21 MBLicence: CC BY-NC-ND

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Guirette, M., Lan, J., McKeown, N., Brown, M. R., Chen, H., DE Vries, P. S., Kim, H., Rebholz, C. M., Morrison, A. C., Bartz, T. M., Fretts, A. M., Guo, X., Lemaitre, R. N., Liu, C.-T., Noordam, R., DE Mutsert, R., Rosendaal, F. R., Wang, C. A., Beilin, L., ... Ma, J. (2023). Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure. medRxiv : the preprint server for health sciences https://doi.org/10.1101/2023.11.10.23298402

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title = "Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure",

abstract = "OBJECTIVE: We examined interactions between genotype and a Dietary Approaches to Stop Hypertension (DASH) diet score in relation to systolic blood pressure (SBP).METHODS: We analyzed up to 9,420,585 biallelic imputed single nucleotide polymorphisms (SNPs) in up to 127,282 individuals of six population groups (91\% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (CHARGE; n=35,660) and UK Biobank (n=91,622) and performed European population-specific and cross-population meta-analyses.RESULTS: We identified three loci in European-specific analyses and an additional four loci in cross-population analyses at P for interaction < 5e-8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency = 0.03) and the DASH diet score (P for interaction = 4e-8; P for heterogeneity = 0.35) in European population, where the interaction effect size was 0.42±0.09 mm Hg (P for interaction = 9.4e-7) and 0.20±0.06 mm Hg (P for interaction = 0.001) in CHARGE and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with cis-expression quantitative trait loci (eQTL) variants (P = 4e-273) and cis-DNA methylation quantitative trait loci (mQTL) variants (P = 1e-300). While the closest gene for rs117878928 is MTHFS, the highest narrow sense heritability accounted by SNPs potentially interacting with the DASH diet score in this locus was for gene ST20 at 15q25.1. CONCLUSION: We demonstrated gene-DASH diet score interaction effects on SBP in several loci. Studies with larger diverse populations are needed to validate our findings.",

author = "M{\'e}lanie Guirette and Jessie Lan and Nicola McKeown and Brown, \{Michael R\} and Han Chen and \{DE Vries\}, \{Paul S\} and Hyunju Kim and Rebholz, \{Casey M\} and Morrison, \{Alanna C\} and Bartz, \{Traci M\} and Fretts, \{Amanda M\} and Xiuqing Guo and Lemaitre, \{Rozenn N\} and Ching-Ti Liu and Raymond Noordam and \{DE Mutsert\}, Ren{\'e}e and Rosendaal, \{Frits R\} and Wang, \{Carol A\} and Lawrence Beilin and Mori, \{Trevor A\} and Oddy, \{Wendy H\} and Pennell, \{Craig E\} and Chai, \{Jin Fang\} and Clare Whitton and \{VAN Dam\}, \{Rob M\} and Jianjun Liu and Tai, \{E Shyong\} and Xueling Sim and Neuhouser, \{Marian L\} and Charles Kooperberg and Lesley Tinker and Nora Franceschini and Tianxiao Huan and Winkler, \{Thomas W\} and Bentley, \{Amy R\} and Gauderman, \{W James\} and Luc Heerkens and Toshiko Tanaka and \{van Rooij\}, Jeroen and Munroe, \{Patricia B\} and Warren, \{Helen R\} and Trudy Voortman and Honglei Chen and Rao, \{D C\} and Daniel Levy and Jiantao Ma",

year = "2023",

month = nov,

day = "12",

doi = "10.1101/2023.11.10.23298402",

language = "English",

series = "medRxiv : the preprint server for health sciences",

type = "WorkingPaper",

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Guirette, M, Lan, J, McKeown, N, Brown, MR, Chen, H, DE Vries, PS, Kim, H, Rebholz, CM, Morrison, AC, Bartz, TM, Fretts, AM, Guo, X, Lemaitre, RN, Liu, C-T, Noordam, R, DE Mutsert, R, Rosendaal, FR, Wang, CA, Beilin, L, Mori, TA, Oddy, WH, Pennell, CE, Chai, JF, Whitton, C, VAN Dam, RM, Liu, J, Tai, ES, Sim, X, Neuhouser, ML, Kooperberg, C, Tinker, L, Franceschini, N, Huan, T, Winkler, TW, Bentley, AR, Gauderman, WJ, Heerkens, L, Tanaka, T, van Rooij, J, Munroe, PB, Warren, HR, Voortman, T, Chen, H, Rao, DC, Levy, D & Ma, J 2023 'Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure' medRxiv : the preprint server for health sciences. https://doi.org/10.1101/2023.11.10.23298402

TY - UNPB

T1 - Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

AU - Guirette, Mélanie

AU - Lan, Jessie

AU - McKeown, Nicola

AU - Brown, Michael R

AU - Chen, Han

AU - DE Vries, Paul S

AU - Kim, Hyunju

AU - Rebholz, Casey M

AU - Morrison, Alanna C

AU - Bartz, Traci M

AU - Fretts, Amanda M

AU - Guo, Xiuqing

AU - Lemaitre, Rozenn N

AU - Liu, Ching-Ti

AU - Noordam, Raymond

AU - DE Mutsert, Renée

AU - Rosendaal, Frits R

AU - Wang, Carol A

AU - Beilin, Lawrence

AU - Mori, Trevor A

AU - Oddy, Wendy H

AU - Pennell, Craig E

AU - Chai, Jin Fang

AU - Whitton, Clare

AU - VAN Dam, Rob M

AU - Liu, Jianjun

AU - Tai, E Shyong

AU - Sim, Xueling

AU - Neuhouser, Marian L

AU - Kooperberg, Charles

AU - Tinker, Lesley

AU - Franceschini, Nora

AU - Huan, Tianxiao

AU - Winkler, Thomas W

AU - Bentley, Amy R

AU - Gauderman, W James

AU - Heerkens, Luc

AU - Tanaka, Toshiko

AU - van Rooij, Jeroen

AU - Munroe, Patricia B

AU - Warren, Helen R

AU - Voortman, Trudy

AU - Chen, Honglei

AU - Rao, D C

AU - Levy, Daniel

AU - Ma, Jiantao

PY - 2023/11/12

Y1 - 2023/11/12

N2 - OBJECTIVE: We examined interactions between genotype and a Dietary Approaches to Stop Hypertension (DASH) diet score in relation to systolic blood pressure (SBP).METHODS: We analyzed up to 9,420,585 biallelic imputed single nucleotide polymorphisms (SNPs) in up to 127,282 individuals of six population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (CHARGE; n=35,660) and UK Biobank (n=91,622) and performed European population-specific and cross-population meta-analyses.RESULTS: We identified three loci in European-specific analyses and an additional four loci in cross-population analyses at P for interaction < 5e-8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency = 0.03) and the DASH diet score (P for interaction = 4e-8; P for heterogeneity = 0.35) in European population, where the interaction effect size was 0.42±0.09 mm Hg (P for interaction = 9.4e-7) and 0.20±0.06 mm Hg (P for interaction = 0.001) in CHARGE and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with cis-expression quantitative trait loci (eQTL) variants (P = 4e-273) and cis-DNA methylation quantitative trait loci (mQTL) variants (P = 1e-300). While the closest gene for rs117878928 is MTHFS, the highest narrow sense heritability accounted by SNPs potentially interacting with the DASH diet score in this locus was for gene ST20 at 15q25.1. CONCLUSION: We demonstrated gene-DASH diet score interaction effects on SBP in several loci. Studies with larger diverse populations are needed to validate our findings.

AB - OBJECTIVE: We examined interactions between genotype and a Dietary Approaches to Stop Hypertension (DASH) diet score in relation to systolic blood pressure (SBP).METHODS: We analyzed up to 9,420,585 biallelic imputed single nucleotide polymorphisms (SNPs) in up to 127,282 individuals of six population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (CHARGE; n=35,660) and UK Biobank (n=91,622) and performed European population-specific and cross-population meta-analyses.RESULTS: We identified three loci in European-specific analyses and an additional four loci in cross-population analyses at P for interaction < 5e-8. We observed a consistent interaction between rs117878928 at 15q25.1 (minor allele frequency = 0.03) and the DASH diet score (P for interaction = 4e-8; P for heterogeneity = 0.35) in European population, where the interaction effect size was 0.42±0.09 mm Hg (P for interaction = 9.4e-7) and 0.20±0.06 mm Hg (P for interaction = 0.001) in CHARGE and the UK Biobank, respectively. The 1 Mb region surrounding rs117878928 was enriched with cis-expression quantitative trait loci (eQTL) variants (P = 4e-273) and cis-DNA methylation quantitative trait loci (mQTL) variants (P = 1e-300). While the closest gene for rs117878928 is MTHFS, the highest narrow sense heritability accounted by SNPs potentially interacting with the DASH diet score in this locus was for gene ST20 at 15q25.1. CONCLUSION: We demonstrated gene-DASH diet score interaction effects on SBP in several loci. Studies with larger diverse populations are needed to validate our findings.

U2 - 10.1101/2023.11.10.23298402

DO - 10.1101/2023.11.10.23298402

M3 - Preprint

C2 - 37986948

T3 - medRxiv : the preprint server for health sciences

BT - Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

ER -

Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

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