Genome-wide linkage analysis in a Dutch multigenerational family with attention deficit hyperactivity disorder

R Vegt, AM Bertoli Avella, Joke Tulen, Bianca de Graaf, AJMH Verkerk, JSP (Jeroen) Vervoort, CM (Carla) Twigt, JA Maat-Kievit, HR (Ruud) van Tuijl, M van der Lijn, Michiel Hengeveld, Ben Oostra

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Abstract

Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder. Genetics has an important role in the aetiology of this disease. In this study, we describe the clinical findings in a Dutch family with eight patients suffering from ADHD, in whom five had at least one other psychiatric disorder. We performed a genome-wide (parametric and nonparametric) affected-only linkage analysis. Two genomic regions on chromosomes 7 and 14 showed an excess of allele sharing among the definitely affected members of the family with suggestive LOD scores (2.1 and 2.08). Nonparametric linkage analyses (NPL) yielded a maxNPL of 2.92 (P=0.001) for marker D7S502 and a maxNPL score of 2.56 (P=0.003) for marker D14S275. We confirmed that all patients share the same haplotype in each region of 7p15.1-q31.33 and 14q11.2-q22.3. Interestingly, both loci have been reported before in Dutch (affected sib pairs) and German (extended families) ADHD linkage studies. Hopefully, the genome-wide association studies in ADHD will help to highlight specific polymorphisms and genes within the broad areas detected by our, as well as other, linkage studies. European Journal of Human Genetics (2010) 18, 206-211; doi: 10.1038/ejhg.2009.148; published online 26 August 2009
Original languageUndefined/Unknown
Pages (from-to)206-211
Number of pages6
JournalEuropean Journal of Human Genetics
Volume18
Issue number2
DOIs
Publication statusPublished - 2010

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