Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

PK Joshi; N Pirastu; KA Kentistou; K Fischer; E Hofer; KE Schraut; DW Clark; T Nutile; CLK Barnes; P Timmers; X Shen; I Gandin; AF McDaid; TF Hansen; SD Gordon; F Giulianini; TS Boutin; A Abdellaoui; W Zhao; C Medina-Gomez; TM Bartz; S Trompet; LA Lange; L Raffield; Ashley van der Spek; TE Galesloot; P Proitsi; LR Yanek; LF Bielak; A Payton; F Murgia; MP Concas; G Biino; S M Tajuddin; I Seppala; Najaf Amin; E Boerwinkle; AD Borglum; A (Archie) Campbell; EW Demerath; I Demuth; JD Faul; I Ford; A Gialluisi; M Gogele; M Graff; A Hingorani; JJ Hottenga; DM Hougaard; MA Hurme; Arfan Ikram; M Jylha; D Kuh; L Ligthart; CM Lill; U Lindenberger; T Lumley; R Magi; P Marques-Vidal; SE Medland; L Milani; R Nagy; WER Ollier; PA Peyser; PP Pramstaller; PM Ridker; F Rivadeneira; D Ruggiero; Y Saba; R Schmidt; H Schmidt; PE (Eline) Slagboom; BH Smith; JA Smith; N Sotoodehnia; E Steinhagen-Thiessen; FJA van Rooij; AL Verbeek; SH Vermeulen; P Vollenweider; YP Wang; T Werge; JB Whitfield; AB Zonderman; T Lehtimaki; MK Evans; M Pirastu; C Fuchsberger; L Bertram; N Pendleton; SLR Kardia; M Ciullo; DM Becker; A Wong; BM Psaty; Cornelia Duijn; JG Wilson; JW Jukema; L Kiemeney; André Uitterlinden; N Franceschini; KE North; DR Weir; A Metspalu; DI Boomsma; C Hayward; D Chasman; NG Martin; N Sattar; H Campbell; T Esko; Z Kutalik; JF Wilson

doi:10.1038/s41467-017-00934-5

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

PK Joshi
, N Pirastu
, KA Kentistou
, K Fischer
, E Hofer
, KE Schraut
, DW Clark
, T Nutile
, CLK Barnes
, P Timmers
, X Shen
, I Gandin
, AF McDaid
, TF Hansen
, SD Gordon
, F Giulianini
, TS Boutin
, A Abdellaoui
, W Zhao
, C Medina-Gomez

TM Bartz, S Trompet, LA Lange, L Raffield, Ashley van der Spek, TE Galesloot, P Proitsi, LR Yanek, LF Bielak, A Payton, F Murgia, MP Concas, G Biino, S M Tajuddin, I Seppala, Najaf Amin, E Boerwinkle, AD Borglum, A (Archie) Campbell, EW Demerath, I Demuth, JD Faul, I Ford, A Gialluisi, M Gogele, M Graff, A Hingorani, JJ Hottenga, DM Hougaard, MA Hurme, Arfan Ikram, M Jylha, D Kuh, L Ligthart, CM Lill, U Lindenberger, T Lumley, R Magi, P Marques-Vidal, SE Medland, L Milani, R Nagy, WER Ollier, PA Peyser, PP Pramstaller, PM Ridker, F Rivadeneira, D Ruggiero, Y Saba, R Schmidt, H Schmidt, PE (Eline) Slagboom, BH Smith, JA Smith, N Sotoodehnia, E Steinhagen-Thiessen, FJA van Rooij, AL Verbeek, SH Vermeulen, P Vollenweider, YP Wang, T Werge, JB Whitfield, AB Zonderman, T Lehtimaki, MK Evans, M Pirastu, C Fuchsberger, L Bertram, N Pendleton, SLR Kardia, M Ciullo, DM Becker, A Wong, BM Psaty, Cornelia Duijn, JG Wilson, JW Jukema, L Kiemeney, André Uitterlinden, N Franceschini, KE North, DR Weir, A Metspalu, DI Boomsma, C Hayward, D Chasman, NG Martin, N Sattar, H Campbell, T Esko, Z Kutalik, JF Wilson

External organisation

Research output: Contribution to journal › Article › Academic › peer-review

139 Citations (Scopus)

92 Downloads (Pure)

Original language	Undefined/Unknown
Article number	910
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/s41467-017-00934-5
Publication status	Published - 2017

Research programs

EMC OR-01

Access to Document

10.1038/s41467-017-00934-5

REPUB_102496-OA.pdfFinal published version, 2.08 MB

http://hdl.handle.net/1765/102496

Cite this

Joshi, PK., Pirastu, N., Kentistou, KA., Fischer, K., Hofer, E., Schraut, KE., Clark, DW., Nutile, T., Barnes, CLK., Timmers, P., Shen, X., Gandin, I., McDaid, AF., Hansen, TF., Gordon, SD., Giulianini, F., Boutin, TS., Abdellaoui, A., Zhao, W., ... Wilson, JF. (2017). Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications, 8, Article 910. https://doi.org/10.1038/s41467-017-00934-5

@article{e611793d5f0348bea3a5633895a00a20,

title = "Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity",

author = "PK Joshi and N Pirastu and KA Kentistou and K Fischer and E Hofer and KE Schraut and DW Clark and T Nutile and CLK Barnes and P Timmers and X Shen and I Gandin and AF McDaid and TF Hansen and SD Gordon and F Giulianini and TS Boutin and A Abdellaoui and W Zhao and C Medina-Gomez and TM Bartz and S Trompet and LA Lange and L Raffield and \{van der Spek\}, Ashley and TE Galesloot and P Proitsi and LR Yanek and LF Bielak and A Payton and F Murgia and MP Concas and G Biino and Tajuddin, \{S M\} and I Seppala and Najaf Amin and E Boerwinkle and AD Borglum and Campbell, \{A (Archie)\} and EW Demerath and I Demuth and JD Faul and I Ford and A Gialluisi and M Gogele and M Graff and A Hingorani and JJ Hottenga and DM Hougaard and MA Hurme and Arfan Ikram and M Jylha and D Kuh and L Ligthart and CM Lill and U Lindenberger and T Lumley and R Magi and P Marques-Vidal and SE Medland and L Milani and R Nagy and WER Ollier and PA Peyser and PP Pramstaller and PM Ridker and F Rivadeneira and D Ruggiero and Y Saba and R Schmidt and H Schmidt and Slagboom, \{PE (Eline)\} and BH Smith and JA Smith and N Sotoodehnia and E Steinhagen-Thiessen and \{van Rooij\}, FJA and AL Verbeek and SH Vermeulen and P Vollenweider and YP Wang and T Werge and JB Whitfield and AB Zonderman and T Lehtimaki and MK Evans and M Pirastu and C Fuchsberger and L Bertram and N Pendleton and SLR Kardia and M Ciullo and DM Becker and A Wong and BM Psaty and Cornelia Duijn and JG Wilson and JW Jukema and L Kiemeney and Andr{\'e} Uitterlinden and N Franceschini and KE North and DR Weir and A Metspalu and DI Boomsma and C Hayward and D Chasman and NG Martin and N Sattar and H Campbell and T Esko and Z Kutalik and JF Wilson",

year = "2017",

doi = "10.1038/s41467-017-00934-5",

language = "Undefined/Unknown",

volume = "8",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

Joshi, PK, Pirastu, N, Kentistou, KA, Fischer, K, Hofer, E, Schraut, KE, Clark, DW, Nutile, T, Barnes, CLK, Timmers, P, Shen, X, Gandin, I, McDaid, AF, Hansen, TF, Gordon, SD, Giulianini, F, Boutin, TS, Abdellaoui, A, Zhao, W, Medina-Gomez, C, Bartz, TM, Trompet, S, Lange, LA, Raffield, L, van der Spek, A, Galesloot, TE, Proitsi, P, Yanek, LR, Bielak, LF, Payton, A, Murgia, F, Concas, MP, Biino, G, Tajuddin, SM, Seppala, I, Amin, N, Boerwinkle, E, Borglum, AD, Campbell, A, Demerath, EW, Demuth, I, Faul, JD, Ford, I, Gialluisi, A, Gogele, M, Graff, M, Hingorani, A, Hottenga, JJ, Hougaard, DM, Hurme, MA, Ikram, A, Jylha, M, Kuh, D, Ligthart, L, Lill, CM, Lindenberger, U, Lumley, T, Magi, R, Marques-Vidal, P, Medland, SE, Milani, L, Nagy, R, Ollier, WER, Peyser, PA, Pramstaller, PP, Ridker, PM, Rivadeneira, F, Ruggiero, D, Saba, Y, Schmidt, R, Schmidt, H, Slagboom, PE, Smith, BH, Smith, JA, Sotoodehnia, N, Steinhagen-Thiessen, E, van Rooij, FJA, Verbeek, AL, Vermeulen, SH, Vollenweider, P, Wang, YP, Werge, T, Whitfield, JB, Zonderman, AB, Lehtimaki, T, Evans, MK, Pirastu, M, Fuchsberger, C, Bertram, L, Pendleton, N, Kardia, SLR, Ciullo, M, Becker, DM, Wong, A, Psaty, BM, Duijn, C, Wilson, JG, Jukema, JW, Kiemeney, L, Uitterlinden, A, Franceschini, N, North, KE, Weir, DR, Metspalu, A, Boomsma, DI, Hayward, C, Chasman, D, Martin, NG, Sattar, N, Campbell, H, Esko, T, Kutalik, Z & Wilson, JF 2017, 'Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity', Nature Communications, vol. 8, 910. https://doi.org/10.1038/s41467-017-00934-5

TY - JOUR

T1 - Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

AU - Joshi, PK

AU - Pirastu, N

AU - Kentistou, KA

AU - Fischer, K

AU - Hofer, E

AU - Schraut, KE

AU - Clark, DW

AU - Nutile, T

AU - Barnes, CLK

AU - Timmers, P

AU - Shen, X

AU - Gandin, I

AU - McDaid, AF

AU - Hansen, TF

AU - Gordon, SD

AU - Giulianini, F

AU - Boutin, TS

AU - Abdellaoui, A

AU - Zhao, W

AU - Medina-Gomez, C

AU - Bartz, TM

AU - Trompet, S

AU - Lange, LA

AU - Raffield, L

AU - van der Spek, Ashley

AU - Galesloot, TE

AU - Proitsi, P

AU - Yanek, LR

AU - Bielak, LF

AU - Payton, A

AU - Murgia, F

AU - Concas, MP

AU - Biino, G

AU - Tajuddin, S M

AU - Seppala, I

AU - Amin, Najaf

AU - Boerwinkle, E

AU - Borglum, AD

AU - Campbell, A (Archie)

AU - Demerath, EW

AU - Demuth, I

AU - Faul, JD

AU - Ford, I

AU - Gialluisi, A

AU - Gogele, M

AU - Graff, M

AU - Hingorani, A

AU - Hottenga, JJ

AU - Hougaard, DM

AU - Hurme, MA

AU - Ikram, Arfan

AU - Jylha, M

AU - Kuh, D

AU - Ligthart, L

AU - Lill, CM

AU - Lindenberger, U

AU - Lumley, T

AU - Magi, R

AU - Marques-Vidal, P

AU - Medland, SE

AU - Milani, L

AU - Nagy, R

AU - Ollier, WER

AU - Peyser, PA

AU - Pramstaller, PP

AU - Ridker, PM

AU - Rivadeneira, F

AU - Ruggiero, D

AU - Saba, Y

AU - Schmidt, R

AU - Schmidt, H

AU - Slagboom, PE (Eline)

AU - Smith, BH

AU - Smith, JA

AU - Sotoodehnia, N

AU - Steinhagen-Thiessen, E

AU - van Rooij, FJA

AU - Verbeek, AL

AU - Vermeulen, SH

AU - Vollenweider, P

AU - Wang, YP

AU - Werge, T

AU - Whitfield, JB

AU - Zonderman, AB

AU - Lehtimaki, T

AU - Evans, MK

AU - Pirastu, M

AU - Fuchsberger, C

AU - Bertram, L

AU - Pendleton, N

AU - Kardia, SLR

AU - Ciullo, M

AU - Becker, DM

AU - Wong, A

AU - Psaty, BM

AU - Duijn, Cornelia

AU - Wilson, JG

AU - Jukema, JW

AU - Kiemeney, L

AU - Uitterlinden, André

AU - Franceschini, N

AU - North, KE

AU - Weir, DR

AU - Metspalu, A

AU - Boomsma, DI

AU - Hayward, C

AU - Chasman, D

AU - Martin, NG

AU - Sattar, N

AU - Campbell, H

AU - Esko, T

AU - Kutalik, Z

AU - Wilson, JF

PY - 2017

Y1 - 2017

U2 - 10.1038/s41467-017-00934-5

DO - 10.1038/s41467-017-00934-5

M3 - Article

C2 - 29030599

SN - 2041-1723

VL - 8

JO - Nature Communications

JF - Nature Communications

M1 - 910

ER -