Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

TO Kilpelainen; J F M Carli; A A Skowronski; Q Sun; J Kriebel; MF Feitosa; AK Hedman; AW Drong; J E Hayes; JH Zhao; TH Pers; U Schick; N Grarup; Z Kutalik; S Trompet; M Mangino; K Kristiansson; M Beekman; LP Lyytikainen; J Eriksson; Peter Henneman; J Lahti; T Tanaka; JA Luan; F Del Greco; D Pasko; F Renstrom; SM Willems; A Mahajan; LM Rose; XQ Guo; YM Liu; ME Kleber; L Perusse; T Gaunt; TS Ahluwalia; YJ Sung; YF Ramos; Najaf Amin; A Amuzu; I Barroso; C Bellis; J Blangero; BM Buckley; S Bohringer; YDI Chen; A J N de Craen; DR Crosslin; CE Dale; Z Dastani; FR Day; J Deelen; GE Delgado; Ayse Demirkan; FM Finucane; I Ford; ME Garcia; C Gieger; S Gustafsson; G Hallmans; SE Hankinson; AS Havulinna; Cindy Herder; D Hernandez; AA Hicks; DJ Hunter; T Illig; E Ingelsson; A Ioan-Facsinay; JO Jansson; NS Jenny; ME Jorgensen; T Jorgensen; M Karlsson; W Koenig; P Kraft; J Kwekkeboom; T Laatikainen; KH Ladwig; C A LeDuc; G Lowe; YC Lu; P Marques-Vidal; C Meisinger; C Menni; AP Morris; RH Myers; S Mannisto; MA Nalls; L Paternoster; A Peters; A D Pradhan; T Rankinen; LJ Rasmussen-Torvik; W Rathmann; TK Rice; JB Richards; PM Ridker; N Sattar; DB Savage; S Soderberg; NJ Timpson; L Vandenput; D van Heemst; HW Uh; MC Vohl; M Walker; HE Wichmann; E Widen; AR Wood; J Yao; T Zeller; YY Zhang; I Meulenbelt; M Kloppenburg; A Astrup; TIA Sorensen; MA Sarzynski; DC Rao; P Jousilahti; E Vartiainen; Bert Hofman; Fernando Rivadeneira; André Uitterlinden; E Kajantie; C Osmond; A Palotie; JG Eriksson; M Heliovaara; PB Knekt; S Koskinen; A Jula; M Perola; R K Huupponen; JS Viikari; M Kahonen; T Lehtimaki; OT Raitakari; D Mellstrom; M Lorentzon; JP Casas; S Bandinelli; W Marz; Aaron Isaacs; KW van Dijk; Cornelia Duijn; TB Harris; C Bouchard; MA Allison; DI Chasman; C Ohlsson; L Lind; RA Scott; C Langenberg; NJ Wareham; L Ferrucci; TM Frayling; PP Pramstaller; IB Borecki; DM Waterworth; S Bergmann; G Waeber; P Vollenweider; H Vestergaard; T Hansen; O Pedersen; FB Hu; PE (Eline) Slagboom; H Grallert; TD Spector; JW Jukema; RJ Klein; EE Schadt; PW Franks; CM Lindgren; R L Leibel; RJF Loos

doi:10.1038/ncomms10494

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

TO Kilpelainen, J F M Carli, A A Skowronski, Q Sun, J Kriebel, MF Feitosa, AK Hedman, AW Drong, J E Hayes, JH Zhao, TH Pers, U Schick, N Grarup, Z Kutalik, S Trompet, M Mangino, K Kristiansson, M Beekman, LP Lyytikainen, J ErikssonPeter Henneman, J Lahti, T Tanaka, JA Luan, F Del Greco, D Pasko, F Renstrom, SM Willems, A Mahajan, LM Rose, XQ Guo, YM Liu, ME Kleber, L Perusse, T Gaunt, TS Ahluwalia, YJ Sung, YF Ramos, Najaf Amin, A Amuzu, I Barroso, C Bellis, J Blangero, BM Buckley, S Bohringer, YDI Chen, A J N de Craen, DR Crosslin, CE Dale, Z Dastani, FR Day, J Deelen, GE Delgado, Ayse Demirkan, FM Finucane, I Ford, ME Garcia, C Gieger, S Gustafsson, G Hallmans, SE Hankinson, AS Havulinna, Cindy Herder, D Hernandez, AA Hicks, DJ Hunter, T Illig, E Ingelsson, A Ioan-Facsinay, JO Jansson, NS Jenny, ME Jorgensen, T Jorgensen, M Karlsson, W Koenig, P Kraft, J Kwekkeboom, T Laatikainen, KH Ladwig, C A LeDuc, G Lowe, YC Lu, P Marques-Vidal, C Meisinger, C Menni, AP Morris, RH Myers, S Mannisto, MA Nalls, L Paternoster, A Peters, A D Pradhan, T Rankinen, LJ Rasmussen-Torvik, W Rathmann, TK Rice, JB Richards, PM Ridker, N Sattar, DB Savage, S Soderberg, NJ Timpson, L Vandenput, D van Heemst, HW Uh, MC Vohl, M Walker, HE Wichmann, E Widen, AR Wood, J Yao, T Zeller, YY Zhang, I Meulenbelt, M Kloppenburg, A Astrup, TIA Sorensen, MA Sarzynski, DC Rao, P Jousilahti, E Vartiainen, Bert Hofman, Fernando Rivadeneira, André Uitterlinden, E Kajantie, C Osmond, A Palotie, JG Eriksson, M Heliovaara, PB Knekt, S Koskinen, A Jula, M Perola, R K Huupponen, JS Viikari, M Kahonen, T Lehtimaki, OT Raitakari, D Mellstrom, M Lorentzon, JP Casas, S Bandinelli, W Marz, Aaron Isaacs, KW van Dijk, Cornelia Duijn, TB Harris, C Bouchard, MA Allison, DI Chasman, C Ohlsson, L Lind, RA Scott, C Langenberg, NJ Wareham, L Ferrucci, TM Frayling, PP Pramstaller, IB Borecki, DM Waterworth, S Bergmann, G Waeber, P Vollenweider, H Vestergaard, T Hansen, O Pedersen, FB Hu, PE (Eline) Slagboom, H Grallert, TD Spector, JW Jukema, RJ Klein, EE Schadt, PW Franks, CM Lindgren, R L Leibel, RJF Loos

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	Undefined/Unknown
Article number	10494
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms10494
Publication status	Published - 2016

Research programs

EMC MM-01-39-09-A
EMC NIHES-01-64-02

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Cite this

Kilpelainen, TO., Carli, J. F. M., Skowronski, A. A., Sun, Q., Kriebel, J., Feitosa, MF., Hedman, AK., Drong, AW., Hayes, J. E., Zhao, JH., Pers, TH., Schick, U., Grarup, N., Kutalik, Z., Trompet, S., Mangino, M., Kristiansson, K., Beekman, M., Lyytikainen, LP., ... Loos, RJF. (2016). Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nature Communications, 7, Article 10494. https://doi.org/10.1038/ncomms10494

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title = "Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels",

author = "TO Kilpelainen and Carli, {J F M} and Skowronski, {A A} and Q Sun and J Kriebel and MF Feitosa and AK Hedman and AW Drong and Hayes, {J E} and JH Zhao and TH Pers and U Schick and N Grarup and Z Kutalik and S Trompet and M Mangino and K Kristiansson and M Beekman and LP Lyytikainen and J Eriksson and Peter Henneman and J Lahti and T Tanaka and JA Luan and {Del Greco}, F and D Pasko and F Renstrom and SM Willems and A Mahajan and LM Rose and XQ Guo and YM Liu and ME Kleber and L Perusse and T Gaunt and TS Ahluwalia and YJ Sung and YF Ramos and Najaf Amin and A Amuzu and I Barroso and C Bellis and J Blangero and BM Buckley and S Bohringer and YDI Chen and {de Craen}, {A J N} and DR Crosslin and CE Dale and Z Dastani and FR Day and J Deelen and GE Delgado and Ayse Demirkan and FM Finucane and I Ford and ME Garcia and C Gieger and S Gustafsson and G Hallmans and SE Hankinson and AS Havulinna and Cindy Herder and D Hernandez and AA Hicks and DJ Hunter and T Illig and E Ingelsson and A Ioan-Facsinay and JO Jansson and NS Jenny and ME Jorgensen and T Jorgensen and M Karlsson and W Koenig and P Kraft and J Kwekkeboom and T Laatikainen and KH Ladwig and LeDuc, {C A} and G Lowe and YC Lu and P Marques-Vidal and C Meisinger and C Menni and AP Morris and RH Myers and S Mannisto and MA Nalls and L Paternoster and A Peters and Pradhan, {A D} and T Rankinen and LJ Rasmussen-Torvik and W Rathmann and TK Rice and JB Richards and PM Ridker and N Sattar and DB Savage and S Soderberg and NJ Timpson and L Vandenput and {van Heemst}, D and HW Uh and MC Vohl and M Walker and HE Wichmann and E Widen and AR Wood and J Yao and T Zeller and YY Zhang and I Meulenbelt and M Kloppenburg and A Astrup and TIA Sorensen and MA Sarzynski and DC Rao and P Jousilahti and E Vartiainen and Bert Hofman and Fernando Rivadeneira and Andr{\'e} Uitterlinden and E Kajantie and C Osmond and A Palotie and JG Eriksson and M Heliovaara and PB Knekt and S Koskinen and A Jula and M Perola and Huupponen, {R K} and JS Viikari and M Kahonen and T Lehtimaki and OT Raitakari and D Mellstrom and M Lorentzon and JP Casas and S Bandinelli and W Marz and Aaron Isaacs and {van Dijk}, KW and Cornelia Duijn and TB Harris and C Bouchard and MA Allison and DI Chasman and C Ohlsson and L Lind and RA Scott and C Langenberg and NJ Wareham and L Ferrucci and TM Frayling and PP Pramstaller and IB Borecki and DM Waterworth and S Bergmann and G Waeber and P Vollenweider and H Vestergaard and T Hansen and O Pedersen and FB Hu and Slagboom, {PE (Eline)} and H Grallert and TD Spector and JW Jukema and RJ Klein and EE Schadt and PW Franks and CM Lindgren and Leibel, {R L} and RJF Loos",

year = "2016",

doi = "10.1038/ncomms10494",

language = "Undefined/Unknown",

volume = "7",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

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Kilpelainen, TO, Carli, JFM, Skowronski, AA, Sun, Q, Kriebel, J, Feitosa, MF, Hedman, AK, Drong, AW, Hayes, JE, Zhao, JH, Pers, TH, Schick, U, Grarup, N, Kutalik, Z, Trompet, S, Mangino, M, Kristiansson, K, Beekman, M, Lyytikainen, LP, Eriksson, J, Henneman, P, Lahti, J, Tanaka, T, Luan, JA, Del Greco, F, Pasko, D, Renstrom, F, Willems, SM, Mahajan, A, Rose, LM, Guo, XQ, Liu, YM, Kleber, ME, Perusse, L, Gaunt, T, Ahluwalia, TS, Sung, YJ, Ramos, YF, Amin, N, Amuzu, A, Barroso, I, Bellis, C, Blangero, J, Buckley, BM, Bohringer, S, Chen, YDI, de Craen, AJN, Crosslin, DR, Dale, CE, Dastani, Z, Day, FR, Deelen, J, Delgado, GE, Demirkan, A, Finucane, FM, Ford, I, Garcia, ME, Gieger, C, Gustafsson, S, Hallmans, G, Hankinson, SE, Havulinna, AS, Herder, C, Hernandez, D, Hicks, AA, Hunter, DJ, Illig, T, Ingelsson, E, Ioan-Facsinay, A, Jansson, JO, Jenny, NS, Jorgensen, ME, Jorgensen, T, Karlsson, M, Koenig, W, Kraft, P, Kwekkeboom, J, Laatikainen, T, Ladwig, KH, LeDuc, CA, Lowe, G, Lu, YC, Marques-Vidal, P, Meisinger, C, Menni, C, Morris, AP, Myers, RH, Mannisto, S, Nalls, MA, Paternoster, L, Peters, A, Pradhan, AD, Rankinen, T, Rasmussen-Torvik, LJ, Rathmann, W, Rice, TK, Richards, JB, Ridker, PM, Sattar, N, Savage, DB, Soderberg, S, Timpson, NJ, Vandenput, L, van Heemst, D, Uh, HW, Vohl, MC, Walker, M, Wichmann, HE, Widen, E, Wood, AR, Yao, J, Zeller, T, Zhang, YY, Meulenbelt, I, Kloppenburg, M, Astrup, A, Sorensen, TIA, Sarzynski, MA, Rao, DC, Jousilahti, P, Vartiainen, E, Hofman, B , Rivadeneira, F , Uitterlinden, A, Kajantie, E, Osmond, C, Palotie, A, Eriksson, JG, Heliovaara, M, Knekt, PB, Koskinen, S, Jula, A, Perola, M, Huupponen, RK, Viikari, JS, Kahonen, M, Lehtimaki, T, Raitakari, OT, Mellstrom, D, Lorentzon, M, Casas, JP, Bandinelli, S, Marz, W, Isaacs, A, van Dijk, KW, Duijn, C, Harris, TB, Bouchard, C, Allison, MA, Chasman, DI, Ohlsson, C, Lind, L, Scott, RA, Langenberg, C, Wareham, NJ, Ferrucci, L, Frayling, TM, Pramstaller, PP, Borecki, IB, Waterworth, DM, Bergmann, S, Waeber, G, Vollenweider, P, Vestergaard, H, Hansen, T, Pedersen, O, Hu, FB, Slagboom, PE, Grallert, H, Spector, TD, Jukema, JW, Klein, RJ, Schadt, EE, Franks, PW, Lindgren, CM, Leibel, RL & Loos, RJF 2016, 'Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels', Nature Communications, vol. 7, 10494. https://doi.org/10.1038/ncomms10494

TY - JOUR

T1 - Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

AU - Kilpelainen, TO

AU - Carli, J F M

AU - Skowronski, A A

AU - Sun, Q

AU - Kriebel, J

AU - Feitosa, MF

AU - Hedman, AK

AU - Drong, AW

AU - Hayes, J E

AU - Zhao, JH

AU - Pers, TH

AU - Schick, U

AU - Grarup, N

AU - Kutalik, Z

AU - Trompet, S

AU - Mangino, M

AU - Kristiansson, K

AU - Beekman, M

AU - Lyytikainen, LP

AU - Eriksson, J

AU - Henneman, Peter

AU - Lahti, J

AU - Tanaka, T

AU - Luan, JA

AU - Del Greco, F

AU - Pasko, D

AU - Renstrom, F

AU - Willems, SM

AU - Mahajan, A

AU - Rose, LM

AU - Guo, XQ

AU - Liu, YM

AU - Kleber, ME

AU - Perusse, L

AU - Gaunt, T

AU - Ahluwalia, TS

AU - Sung, YJ

AU - Ramos, YF

AU - Amin, Najaf

AU - Amuzu, A

AU - Barroso, I

AU - Bellis, C

AU - Blangero, J

AU - Buckley, BM

AU - Bohringer, S

AU - Chen, YDI

AU - de Craen, A J N

AU - Crosslin, DR

AU - Dale, CE

AU - Dastani, Z

AU - Day, FR

AU - Deelen, J

AU - Delgado, GE

AU - Demirkan, Ayse

AU - Finucane, FM

AU - Ford, I

AU - Garcia, ME

AU - Gieger, C

AU - Gustafsson, S

AU - Hallmans, G

AU - Hankinson, SE

AU - Havulinna, AS

AU - Herder, Cindy

AU - Hernandez, D

AU - Hicks, AA

AU - Hunter, DJ

AU - Illig, T

AU - Ingelsson, E

AU - Ioan-Facsinay, A

AU - Jansson, JO

AU - Jenny, NS

AU - Jorgensen, ME

AU - Jorgensen, T

AU - Karlsson, M

AU - Koenig, W

AU - Kraft, P

AU - Kwekkeboom, J

AU - Laatikainen, T

AU - Ladwig, KH

AU - LeDuc, C A

AU - Lowe, G

AU - Lu, YC

AU - Marques-Vidal, P

AU - Meisinger, C

AU - Menni, C

AU - Morris, AP

AU - Myers, RH

AU - Mannisto, S

AU - Nalls, MA

AU - Paternoster, L

AU - Peters, A

AU - Pradhan, A D

AU - Rankinen, T

AU - Rasmussen-Torvik, LJ

AU - Rathmann, W

AU - Rice, TK

AU - Richards, JB

AU - Ridker, PM

AU - Sattar, N

AU - Savage, DB

AU - Soderberg, S

AU - Timpson, NJ

AU - Vandenput, L

AU - van Heemst, D

AU - Uh, HW

AU - Vohl, MC

AU - Walker, M

AU - Wichmann, HE

AU - Widen, E

AU - Wood, AR

AU - Yao, J

AU - Zeller, T

AU - Zhang, YY

AU - Meulenbelt, I

AU - Kloppenburg, M

AU - Astrup, A

AU - Sorensen, TIA

AU - Sarzynski, MA

AU - Rao, DC

AU - Jousilahti, P

AU - Vartiainen, E

AU - Hofman, Bert

AU - Rivadeneira, Fernando

AU - Uitterlinden, André

AU - Kajantie, E

AU - Osmond, C

AU - Palotie, A

AU - Eriksson, JG

AU - Heliovaara, M

AU - Knekt, PB

AU - Koskinen, S

AU - Jula, A

AU - Perola, M

AU - Huupponen, R K

AU - Viikari, JS

AU - Kahonen, M

AU - Lehtimaki, T

AU - Raitakari, OT

AU - Mellstrom, D

AU - Lorentzon, M

AU - Casas, JP

AU - Bandinelli, S

AU - Marz, W

AU - Isaacs, Aaron

AU - van Dijk, KW

AU - Duijn, Cornelia

AU - Harris, TB

AU - Bouchard, C

AU - Allison, MA

AU - Chasman, DI

AU - Ohlsson, C

AU - Lind, L

AU - Scott, RA

AU - Langenberg, C

AU - Wareham, NJ

AU - Ferrucci, L

AU - Frayling, TM

AU - Pramstaller, PP

AU - Borecki, IB

AU - Waterworth, DM

AU - Bergmann, S

AU - Waeber, G

AU - Vollenweider, P

AU - Vestergaard, H

AU - Hansen, T

AU - Pedersen, O

AU - Hu, FB

AU - Slagboom, PE (Eline)

AU - Grallert, H

AU - Spector, TD

AU - Jukema, JW

AU - Klein, RJ

AU - Schadt, EE

AU - Franks, PW

AU - Lindgren, CM

AU - Leibel, R L

AU - Loos, RJF

PY - 2016

Y1 - 2016

U2 - 10.1038/ncomms10494

DO - 10.1038/ncomms10494

M3 - Article

C2 - 26833098

SN - 2041-1723

VL - 7

JO - Nature Communications

JF - Nature Communications

M1 - 10494

ER -