Ghrelin

TD Muller, R Nogueiras, ML Andermann, ZB Andrews, SD Anker, J Argente, RL Batterham, SC Benoit, CY Bowers, F (Fabio) Broglio, FF Casanueva, D D'Alessio, I Depoortere, A Geliebter, E Ghigo, PA Cole, M Cowley, DE Cummings, A Dagher, S DianoSL Dickson, C Dieguez, R Granata, HJ Grill, K Grove, KM Habegger, K Heppner, ML Heiman, L Holsen, B Holst, A Inui, JO Jansson, H Kirchner, M Korbonits, B Laferrere, CW LeRoux, M Lopez, S Morin, M Nakazato, R Nass, D Perez-Tilve, PT Pfluger, TW Schwartz, RJ Seeley, M Sleeman, Y Sun, L Sussel, J Tong, MO Thorner, AJ (Aart-Jan) van der Lely, LHT van der Ploeg, JM Zigman, M Kojima, K Kangawa, RG Smith, T Horvath, MH Tschop

Research output: Contribution to journalArticleAcademicpeer-review

644 Citations (Scopus)

Abstract

Background: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism. (C) 2015 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Original languageUndefined/Unknown
Pages (from-to)437-460
Number of pages24
JournalMolecular Metabolism
Volume4
Issue number6
DOIs
Publication statusPublished - 2015

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