Ghrelin and Bone

Martijn van der Velde*, Patric Delhanty, Bram van der Eerden, Aart Jan van der Lely, Johannes van Leeuwen

*Corresponding author for this work

Research output: Chapter/Conference proceedingChapterAcademic

29 Citations (Scopus)

Abstract

A consequence of gastrectomy is loss of bone mass. Several mechanisms have been proposed, such as malabsorption of vitamins and minerals. Additionally, a peptide hormone produced in the stomach has been shown to mediate a calcitropic effect on bone. The identity of this peptide has not been elucidated, but ghrelin, produced by A-like cells in the fundus of the stomach, could be a good candidate. Ghrelin stimulates growth hormone (GH) secretion both in vivo and in vitro, and could by this means have a positive effect on bone. There is also evidence for direct effects of ghrelin on bone. We discuss here the role that ghrelin may play in bone metabolism, based on the most recent literature.

Original languageEnglish
Title of host publicationGhrelin
EditorsGerald Litwack
Chapter10
Pages239-258
Number of pages20
DOIs
Publication statusPublished - 2007

Publication series

SeriesVitamins and Hormones
Volume77
ISSN0083-6729

Bibliographical note

Copyright: 2008 Elsevier Inc.

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