TY - CHAP
T1 - Ghrelin and Bone
AU - van der Velde, Martijn
AU - Delhanty, Patric
AU - van der Eerden, Bram
AU - van der Lely, Aart Jan
AU - van Leeuwen, Johannes
N1 - Copyright: 2008 Elsevier Inc.
PY - 2007
Y1 - 2007
N2 - A consequence of gastrectomy is loss of bone mass. Several mechanisms have been proposed, such as malabsorption of vitamins and minerals. Additionally, a peptide hormone produced in the stomach has been shown to mediate a calcitropic effect on bone. The identity of this peptide has not been elucidated, but ghrelin, produced by A-like cells in the fundus of the stomach, could be a good candidate. Ghrelin stimulates growth hormone (GH) secretion both in vivo and in vitro, and could by this means have a positive effect on bone. There is also evidence for direct effects of ghrelin on bone. We discuss here the role that ghrelin may play in bone metabolism, based on the most recent literature.
AB - A consequence of gastrectomy is loss of bone mass. Several mechanisms have been proposed, such as malabsorption of vitamins and minerals. Additionally, a peptide hormone produced in the stomach has been shown to mediate a calcitropic effect on bone. The identity of this peptide has not been elucidated, but ghrelin, produced by A-like cells in the fundus of the stomach, could be a good candidate. Ghrelin stimulates growth hormone (GH) secretion both in vivo and in vitro, and could by this means have a positive effect on bone. There is also evidence for direct effects of ghrelin on bone. We discuss here the role that ghrelin may play in bone metabolism, based on the most recent literature.
UR - https://www.scopus.com/pages/publications/35648952696
U2 - 10.1016/S0083-6729(06)77010-8
DO - 10.1016/S0083-6729(06)77010-8
M3 - Chapter
C2 - 17983859
AN - SCOPUS:35648952696
SN - 0123736854
SN - 9780123736857
T3 - Vitamins and Hormones
SP - 239
EP - 258
BT - Ghrelin
A2 - Litwack, Gerald
ER -