GIGYF2 mutations are not a frequent cause of familial Parkinson's disease

Alessio Di Fonzo, E Fabrizio, A Thomas, E Fincati, R Marconi, M Tinazzi, Guido Breedveld, Erik Simons, HF Chien, JJ Ferreira, W Horstink, G Abbruzzese, B Borroni, G Cossu, A Dalla Libera, G Fabbrini, M Guidi, M de Mari, L Lopiano, E MartignoniP Marini, M Onofrj, A Padovani, F Stocchi, V Toni, C Sampaio, ER Barbosa, G Meco, Ben Oostra, Vincenzo Bonifati

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Abstract

Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD. (C) 2009 Elsevier Ltd. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)703-705
Number of pages3
JournalParkinsonism & Related Disorders
Volume15
Issue number9
DOIs
Publication statusPublished - 2009

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