GIGYF2 mutations are not a frequent cause of familial Parkinson's disease

Alessio Di Fonzo; E Fabrizio; A Thomas; E Fincati; R Marconi; M Tinazzi; Guido Breedveld; Erik Simons; HF Chien; JJ Ferreira; W Horstink; G Abbruzzese; B Borroni; G Cossu; A Dalla Libera; G Fabbrini; M Guidi; M de Mari; L Lopiano; E Martignoni; P Marini; M Onofrj; A Padovani; F Stocchi; V Toni; C Sampaio; ER Barbosa; G Meco; Ben Oostra; Vincenzo Bonifati

doi:10.1016/j.parkreldis.2009.05.001

GIGYF2 mutations are not a frequent cause of familial Parkinson's disease

Alessio Di Fonzo, E Fabrizio, A Thomas, E Fincati, R Marconi, M Tinazzi, Guido Breedveld, Erik Simons, HF Chien, JJ Ferreira, W Horstink, G Abbruzzese, B Borroni, G Cossu, A Dalla Libera, G Fabbrini, M Guidi, M de Mari, L Lopiano, E MartignoniP Marini, M Onofrj, A Padovani, F Stocchi, V Toni, C Sampaio, ER Barbosa, G Meco, Ben Oostra, Vincenzo Bonifati

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD. (C) 2009 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	703-705
Number of pages	3
Journal	Parkinsonism & Related Disorders
Volume	15
Issue number	9
DOIs	https://doi.org/10.1016/j.parkreldis.2009.05.001
Publication status	Published - 2009

Research programs

EMC MGC-02-96-01

Access to Document

10.1016/j.parkreldis.2009.05.001

http://hdl.handle.net/1765/24490

Cite this

Di Fonzo, A., Fabrizio, E., Thomas, A., Fincati, E., Marconi, R., Tinazzi, M., Breedveld, G., Simons, E., Chien, HF., Ferreira, JJ., Horstink, W., Abbruzzese, G., Borroni, B., Cossu, G., Dalla Libera, A., Fabbrini, G., Guidi, M., de Mari, M., Lopiano, L., ... Bonifati, V. (2009). GIGYF2 mutations are not a frequent cause of familial Parkinson's disease. Parkinsonism & Related Disorders, 15(9), 703-705. https://doi.org/10.1016/j.parkreldis.2009.05.001

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title = "GIGYF2 mutations are not a frequent cause of familial Parkinson's disease",

abstract = "Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD. (C) 2009 Elsevier Ltd. All rights reserved.",

author = "{Di Fonzo}, Alessio and E Fabrizio and A Thomas and E Fincati and R Marconi and M Tinazzi and Guido Breedveld and Erik Simons and HF Chien and JJ Ferreira and W Horstink and G Abbruzzese and B Borroni and G Cossu and {Dalla Libera}, A and G Fabbrini and M Guidi and {de Mari}, M and L Lopiano and E Martignoni and P Marini and M Onofrj and A Padovani and F Stocchi and V Toni and C Sampaio and ER Barbosa and G Meco and Ben Oostra and Vincenzo Bonifati",

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doi = "10.1016/j.parkreldis.2009.05.001",

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Di Fonzo, A, Fabrizio, E, Thomas, A, Fincati, E, Marconi, R, Tinazzi, M, Breedveld, G, Simons, E, Chien, HF, Ferreira, JJ, Horstink, W, Abbruzzese, G, Borroni, B, Cossu, G, Dalla Libera, A, Fabbrini, G, Guidi, M, de Mari, M, Lopiano, L, Martignoni, E, Marini, P, Onofrj, M, Padovani, A, Stocchi, F, Toni, V, Sampaio, C, Barbosa, ER, Meco, G, Oostra, B & Bonifati, V 2009, 'GIGYF2 mutations are not a frequent cause of familial Parkinson's disease', Parkinsonism & Related Disorders, vol. 15, no. 9, pp. 703-705. https://doi.org/10.1016/j.parkreldis.2009.05.001

TY - JOUR

T1 - GIGYF2 mutations are not a frequent cause of familial Parkinson's disease

AU - Di Fonzo, Alessio

AU - Fabrizio, E

AU - Thomas, A

AU - Fincati, E

AU - Marconi, R

AU - Tinazzi, M

AU - Breedveld, Guido

AU - Simons, Erik

AU - Chien, HF

AU - Ferreira, JJ

AU - Horstink, W

AU - Abbruzzese, G

AU - Borroni, B

AU - Cossu, G

AU - Dalla Libera, A

AU - Fabbrini, G

AU - Guidi, M

AU - de Mari, M

AU - Lopiano, L

AU - Martignoni, E

AU - Marini, P

AU - Onofrj, M

AU - Padovani, A

AU - Stocchi, F

AU - Toni, V

AU - Sampaio, C

AU - Barbosa, ER

AU - Meco, G

AU - Oostra, Ben

AU - Bonifati, Vincenzo

PY - 2009

Y1 - 2009

N2 - Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD. (C) 2009 Elsevier Ltd. All rights reserved.

AB - Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD. (C) 2009 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.parkreldis.2009.05.001

DO - 10.1016/j.parkreldis.2009.05.001

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