GLM-Regularized Low-Rank Factorization For Extracting Functional Response From Swept-3D Functional Ultrasound

Aybuke Erol*, Bastian Generowicz, Pieter Kruizinga, Borbala Hunyadi

*Corresponding author for this work

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review

Abstract

Functional ultrasound (fUS) is an emerging neuroimaging modality that indirectly measures neural activity by detecting fluctuations in local blood dynamics. fUS acquisitions typically rely on the use of a 1D array transducer, which records hemodynamic activity in a single plane. A new technique named swept-3D fUS imaging obtains a full 3D volume of the brain by continuously moving a 1D array back-and-forth over the volume of interest. The standard procedure in fUS imaging involves filtering and averaging a number of ultrasound frames obtained at a single location to compute power-Doppler images, yet, in case of swept-3D fUS, the location of the recorded slice shifts at each time instant due to probe motion. In this work, we aim at discovering task-relevant components from 3D fUS data while taking into account the spatiotemporal differences in adjacent slices. We propose an alternating optimization scheme with general liner model-based regularization, and validate our method on swept-3D fUS data by identifying active regions and time traces within the mouse brain during a visual experiment.

Original languageEnglish
Title of host publicationICASSPW 2023 - 2023 IEEE International Conference on Acoustics, Speech and Signal Processing Workshops, Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9798350302615
DOIs
Publication statusPublished - 2023
Event2023 IEEE International Conference on Acoustics, Speech and Signal Processing Workshops, ICASSPW 2023 - Rhodes Island, Greece
Duration: 4 Jun 202310 Jun 2023

Publication series

SeriesICASSPW 2023 - 2023 IEEE International Conference on Acoustics, Speech and Signal Processing Workshops, Proceedings

Conference

Conference2023 IEEE International Conference on Acoustics, Speech and Signal Processing Workshops, ICASSPW 2023
Country/TerritoryGreece
CityRhodes Island
Period4/06/2310/06/23

Bibliographical note

Publisher Copyright:
© 2023 IEEE.

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