Global Prevalence and Major Risk Factors of Diabetic Retinopathy

JWY Yau; SL Rogers; R Kawasaki; EL Lamoureux; JW Kowalski; T Bek; SJ Chen; JM Dekker; A Fletcher; J Grauslund; S Haffner; RF Hamman; Kamran Ikram; T Kayama; BEK Klein; R Klein; S Krishnaiah; K Mayurasakorn; JP O'Hare; TJ Orchard; M Porta; M Rema; MS Roy; T Sharma; J Shaw; H Taylor; JM Tielsch; R Varma; JJ Wang; NL Wang; S West; L Xu; M Yasuda; XZ Zhang; P Mitchell; TY Wong

doi:10.2337/dc11-1909

Global Prevalence and Major Risk Factors of Diabetic Retinopathy

JWY Yau, SL Rogers, R Kawasaki, EL Lamoureux, JW Kowalski, T Bek, SJ Chen, JM Dekker, A Fletcher, J Grauslund, S Haffner, RF Hamman, Kamran Ikram, T Kayama, BEK Klein, R Klein, S Krishnaiah, K Mayurasakorn, JP O'Hare, TJ OrchardM Porta, M Rema, MS Roy, T Sharma, J Shaw, H Taylor, JM Tielsch, R Varma, JJ Wang, NL Wang, S West, L Xu, M Yasuda, XZ Zhang, P Mitchell, TY Wong

Ophthalmology

Research output: Contribution to journal › Article › Academic › peer-review

3082 Citations (Scopus)

Abstract

OBJECTIVE-To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. RESEARCH DESIGN AND METHODS-A pooled analysis using individual participant data from population-based studies around the world was performed. A systematic literature review was conducted to identify all population-based studies in general populations or individuals with diabetes who had ascertained DR from retinal photographs. Studies provided data for DR end points, including any DR, proliferative DR, diabetic macular edema, and VTDR, and also major systemic risk factors. Pooled prevalence esti RESULTS-A total of 35 studies (1980-2008) provided data from 22,896 individuals with diabetes. The overall prevalence was 34.6% (95% CI 34.5-34.8) for any DR, 6.96% (6.87-7.04) for proliferative DR, 6.81% (6.74-6.89) for diabetic macular edema, and 10.2% (10.1-10.3) for VTDR. All DR prevalence end points increased with diabetes duration, hemoglobin Air, and blood pressure levels and were higher in people with type 1 compared with type 2 diabetes. CONCLUSIONS-There are approximately 93 million people with DR, 17 million with proliferative DR, 21 million with diabetic macular edema, and 28 million with VTDR worldwide. Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR. These data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence. This study is limited by data pooled from studies at different time points, with di

Original language	Undefined/Unknown
Pages (from-to)	556-564
Number of pages	9
Journal	Diabetes Care
Volume	35
Issue number	3
DOIs	https://doi.org/10.2337/dc11-1909
Publication status	Published - 2012

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10.2337/dc11-1909

http://hdl.handle.net/1765/61489

Cite this

Yau, JWY., Rogers, SL., Kawasaki, R., Lamoureux, EL., Kowalski, JW., Bek, T., Chen, SJ., Dekker, JM., Fletcher, A., Grauslund, J., Haffner, S., Hamman, RF., Ikram, K., Kayama, T., Klein, BEK., Klein, R., Krishnaiah, S., Mayurasakorn, K., O'Hare, JP., ... Wong, TY. (2012). Global Prevalence and Major Risk Factors of Diabetic Retinopathy. Diabetes Care, 35(3), 556-564. https://doi.org/10.2337/dc11-1909

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title = "Global Prevalence and Major Risk Factors of Diabetic Retinopathy",

abstract = "OBJECTIVE-To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. RESEARCH DESIGN AND METHODS-A pooled analysis using individual participant data from population-based studies around the world was performed. A systematic literature review was conducted to identify all population-based studies in general populations or individuals with diabetes who had ascertained DR from retinal photographs. Studies provided data for DR end points, including any DR, proliferative DR, diabetic macular edema, and VTDR, and also major systemic risk factors. Pooled prevalence esti RESULTS-A total of 35 studies (1980-2008) provided data from 22,896 individuals with diabetes. The overall prevalence was 34.6% (95% CI 34.5-34.8) for any DR, 6.96% (6.87-7.04) for proliferative DR, 6.81% (6.74-6.89) for diabetic macular edema, and 10.2% (10.1-10.3) for VTDR. All DR prevalence end points increased with diabetes duration, hemoglobin Air, and blood pressure levels and were higher in people with type 1 compared with type 2 diabetes. CONCLUSIONS-There are approximately 93 million people with DR, 17 million with proliferative DR, 21 million with diabetic macular edema, and 28 million with VTDR worldwide. Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR. These data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence. This study is limited by data pooled from studies at different time points, with di",

author = "JWY Yau and SL Rogers and R Kawasaki and EL Lamoureux and JW Kowalski and T Bek and SJ Chen and JM Dekker and A Fletcher and J Grauslund and S Haffner and RF Hamman and Kamran Ikram and T Kayama and BEK Klein and R Klein and S Krishnaiah and K Mayurasakorn and JP O'Hare and TJ Orchard and M Porta and M Rema and MS Roy and T Sharma and J Shaw and H Taylor and JM Tielsch and R Varma and JJ Wang and NL Wang and S West and L Xu and M Yasuda and XZ Zhang and P Mitchell and TY Wong",

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doi = "10.2337/dc11-1909",

language = "Undefined/Unknown",

volume = "35",

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Yau, JWY, Rogers, SL, Kawasaki, R, Lamoureux, EL, Kowalski, JW, Bek, T, Chen, SJ, Dekker, JM, Fletcher, A, Grauslund, J, Haffner, S, Hamman, RF, Ikram, K, Kayama, T, Klein, BEK, Klein, R, Krishnaiah, S, Mayurasakorn, K, O'Hare, JP, Orchard, TJ, Porta, M, Rema, M, Roy, MS, Sharma, T, Shaw, J, Taylor, H, Tielsch, JM, Varma, R, Wang, JJ, Wang, NL, West, S, Xu, L, Yasuda, M, Zhang, XZ, Mitchell, P & Wong, TY 2012, 'Global Prevalence and Major Risk Factors of Diabetic Retinopathy', Diabetes Care, vol. 35, no. 3, pp. 556-564. https://doi.org/10.2337/dc11-1909

TY - JOUR

T1 - Global Prevalence and Major Risk Factors of Diabetic Retinopathy

AU - Yau, JWY

AU - Rogers, SL

AU - Kawasaki, R

AU - Lamoureux, EL

AU - Kowalski, JW

AU - Bek, T

AU - Chen, SJ

AU - Dekker, JM

AU - Fletcher, A

AU - Grauslund, J

AU - Haffner, S

AU - Hamman, RF

AU - Ikram, Kamran

AU - Kayama, T

AU - Klein, BEK

AU - Klein, R

AU - Krishnaiah, S

AU - Mayurasakorn, K

AU - O'Hare, JP

AU - Orchard, TJ

AU - Porta, M

AU - Rema, M

AU - Roy, MS

AU - Sharma, T

AU - Shaw, J

AU - Taylor, H

AU - Tielsch, JM

AU - Varma, R

AU - Wang, JJ

AU - Wang, NL

AU - West, S

AU - Xu, L

AU - Yasuda, M

AU - Zhang, XZ

AU - Mitchell, P

AU - Wong, TY

PY - 2012

Y1 - 2012

N2 - OBJECTIVE-To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. RESEARCH DESIGN AND METHODS-A pooled analysis using individual participant data from population-based studies around the world was performed. A systematic literature review was conducted to identify all population-based studies in general populations or individuals with diabetes who had ascertained DR from retinal photographs. Studies provided data for DR end points, including any DR, proliferative DR, diabetic macular edema, and VTDR, and also major systemic risk factors. Pooled prevalence esti RESULTS-A total of 35 studies (1980-2008) provided data from 22,896 individuals with diabetes. The overall prevalence was 34.6% (95% CI 34.5-34.8) for any DR, 6.96% (6.87-7.04) for proliferative DR, 6.81% (6.74-6.89) for diabetic macular edema, and 10.2% (10.1-10.3) for VTDR. All DR prevalence end points increased with diabetes duration, hemoglobin Air, and blood pressure levels and were higher in people with type 1 compared with type 2 diabetes. CONCLUSIONS-There are approximately 93 million people with DR, 17 million with proliferative DR, 21 million with diabetic macular edema, and 28 million with VTDR worldwide. Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR. These data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence. This study is limited by data pooled from studies at different time points, with di

AB - OBJECTIVE-To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. RESEARCH DESIGN AND METHODS-A pooled analysis using individual participant data from population-based studies around the world was performed. A systematic literature review was conducted to identify all population-based studies in general populations or individuals with diabetes who had ascertained DR from retinal photographs. Studies provided data for DR end points, including any DR, proliferative DR, diabetic macular edema, and VTDR, and also major systemic risk factors. Pooled prevalence esti RESULTS-A total of 35 studies (1980-2008) provided data from 22,896 individuals with diabetes. The overall prevalence was 34.6% (95% CI 34.5-34.8) for any DR, 6.96% (6.87-7.04) for proliferative DR, 6.81% (6.74-6.89) for diabetic macular edema, and 10.2% (10.1-10.3) for VTDR. All DR prevalence end points increased with diabetes duration, hemoglobin Air, and blood pressure levels and were higher in people with type 1 compared with type 2 diabetes. CONCLUSIONS-There are approximately 93 million people with DR, 17 million with proliferative DR, 21 million with diabetic macular edema, and 28 million with VTDR worldwide. Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR. These data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence. This study is limited by data pooled from studies at different time points, with di

U2 - 10.2337/dc11-1909

DO - 10.2337/dc11-1909

M3 - Article

SN - 0149-5992

VL - 35

SP - 556

EP - 564

JO - Diabetes Care

JF - Diabetes Care

IS - 3

ER -