Glutamic acid decarboxylase antibodies in screening for autoimmune diabetes: influence of comorbidity, age, and sex on specificity and treshold values

Manou R. Batstra; Arianne van Driel; Jacob S. Petersen; Cees A. van Donselaar; Maarten J. van Tol; G. Jan Bruining; Diederick E. Grobbee; Thomas Dyrberg; Henk-Jan Aanstoot

doi:10.1093/clinchem/45.12.2269

Glutamic acid decarboxylase antibodies in screening for autoimmune diabetes: influence of comorbidity, age, and sex on specificity and treshold values

Manou R. Batstra^*
, Arianne van Driel
, Jacob S. Petersen
, Cees A. van Donselaar
, Maarten J. van Tol
, G. Jan Bruining
, Diederick E. Grobbee
, Thomas Dyrberg
, Henk-Jan Aanstoot

^*Corresponding author for this work

Erasmus University Medical Centre
St. Clara's Hospital - Rotterdam
Leiden University Medical Centre
Novo Nordisk
IJsselland Ziekenhuis

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This study demonstrates that age- and sex-nondefined populations can be used for definition of reference values for glutamic acid decarboxylase (GAD65) antibodies and that comorbidity involving tissues that express GAD needs not be taken into account when screening for GAD antibodies. Because storage conditions may significantly affect the outcome of GAD antibody tests, these need to be monitored meticulously in collaborative studies.

Original language	English
Pages (from-to)	2269-2272
Number of pages	4
Journal	Clinical Chemistry
Volume	45
Issue number	12
DOIs	https://doi.org/10.1093/clinchem/45.12.2269
Publication status	Published - 1999

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EMC MM-01-54-01

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http://hdl.handle.net/1765/9205

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Batstra, M. R., van Driel, A., Petersen, J. S., van Donselaar, C. A., van Tol, M. J., Bruining, G. J., Grobbee, D. E., Dyrberg, T., & Aanstoot, H.-J. (1999). Glutamic acid decarboxylase antibodies in screening for autoimmune diabetes: influence of comorbidity, age, and sex on specificity and treshold values. Clinical Chemistry, 45(12), 2269-2272. https://doi.org/10.1093/clinchem/45.12.2269

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abstract = "This study demonstrates that age- and sex-nondefined populations can be used for definition of reference values for glutamic acid decarboxylase (GAD65) antibodies and that comorbidity involving tissues that express GAD needs not be taken into account when screening for GAD antibodies. Because storage conditions may significantly affect the outcome of GAD antibody tests, these need to be monitored meticulously in collaborative studies.",

author = "Batstra, \{Manou R.\} and \{van Driel\}, Arianne and Petersen, \{Jacob S.\} and \{van Donselaar\}, \{Cees A.\} and \{van Tol\}, \{Maarten J.\} and Bruining, \{G. Jan\} and Grobbee, \{Diederick E.\} and Thomas Dyrberg and Henk-Jan Aanstoot",

year = "1999",

doi = "10.1093/clinchem/45.12.2269",

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Batstra, MR, van Driel, A, Petersen, JS, van Donselaar, CA, van Tol, MJ, Bruining, GJ, Grobbee, DE, Dyrberg, T & Aanstoot, H-J 1999, 'Glutamic acid decarboxylase antibodies in screening for autoimmune diabetes: influence of comorbidity, age, and sex on specificity and treshold values', Clinical Chemistry, vol. 45, no. 12, pp. 2269-2272. https://doi.org/10.1093/clinchem/45.12.2269

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AU - Batstra, Manou R.

AU - van Driel, Arianne

AU - Petersen, Jacob S.

AU - van Donselaar, Cees A.

AU - van Tol, Maarten J.

AU - Bruining, G. Jan

AU - Grobbee, Diederick E.

AU - Dyrberg, Thomas

AU - Aanstoot, Henk-Jan

PY - 1999

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AB - This study demonstrates that age- and sex-nondefined populations can be used for definition of reference values for glutamic acid decarboxylase (GAD65) antibodies and that comorbidity involving tissues that express GAD needs not be taken into account when screening for GAD antibodies. Because storage conditions may significantly affect the outcome of GAD antibody tests, these need to be monitored meticulously in collaborative studies.

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DO - 10.1093/clinchem/45.12.2269

M3 - Article

C2 - 10585365

SN - 0009-9147

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SP - 2269

EP - 2272

JO - Clinical Chemistry

JF - Clinical Chemistry

IS - 12

ER -

Glutamic acid decarboxylase antibodies in screening for autoimmune diabetes: influence of comorbidity, age, and sex on specificity and treshold values

Abstract

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