Granulomatous hepatitis caused by bacillus Calmette-Guerin (BCG) infection after BCG bladder instillation

F. W.G. Leebeek; R. J.Th Ouwendijk; A. H.J. Kolk; A. Dees; J. Ch E. Meek; J. E. Nienhuis; A. M. Dingemans-Dumas

doi:10.1136/gut.38.4.616

Granulomatous hepatitis caused by bacillus Calmette-Guerin (BCG) infection after BCG bladder instillation

F. W.G. Leebeek^*, R. J.Th Ouwendijk, A. H.J. Kolk, A. Dees, J. Ch E. Meek, J. E. Nienhuis, A. M. Dingemans-Dumas

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

66 Citations (Scopus)

Abstract

Background -
Bladder instillations with Bacillus Calmette-Guerin (BCG) are commonly used as immunotherapy for bladder carcinoma. Sometimes patients experience serious systemic side effects, such as sepsis or pneumonitis. Granulomatous hepatitis is a rare serious side effect, which has been considered a hypersensitivity reaction to BCG.

Patient -
The first case of granulomatous hepatitis after BCG bladder instillation in which mycobacteria were identified by staining techniques and mycobacterial DNA was detected in liver tissue using the polymerase chain reaction is reported.

Conclusion -
The granulomatous hepatitis was caused by BCG infection of the liver after haematogenous dissemination of BCG, rather than hypersensitivity.

Original language	English
Pages (from-to)	616-618
Number of pages	3
Journal	Gut
Volume	38
Issue number	4
DOIs	https://doi.org/10.1136/gut.38.4.616
Publication status	Published - 1 Apr 1996
Externally published	Yes

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title = "Granulomatous hepatitis caused by bacillus Calmette-Guerin (BCG) infection after BCG bladder instillation",

abstract = "Background - Bladder instillations with Bacillus Calmette-Guerin (BCG) are commonly used as immunotherapy for bladder carcinoma. Sometimes patients experience serious systemic side effects, such as sepsis or pneumonitis. Granulomatous hepatitis is a rare serious side effect, which has been considered a hypersensitivity reaction to BCG. Patient - The first case of granulomatous hepatitis after BCG bladder instillation in which mycobacteria were identified by staining techniques and mycobacterial DNA was detected in liver tissue using the polymerase chain reaction is reported. Conclusion - The granulomatous hepatitis was caused by BCG infection of the liver after haematogenous dissemination of BCG, rather than hypersensitivity.",

author = "Leebeek, {F. W.G.} and Ouwendijk, {R. J.Th} and Kolk, {A. H.J.} and A. Dees and Meek, {J. Ch E.} and Nienhuis, {J. E.} and Dingemans-Dumas, {A. M.}",

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doi = "10.1136/gut.38.4.616",

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T1 - Granulomatous hepatitis caused by bacillus Calmette-Guerin (BCG) infection after BCG bladder instillation

AU - Leebeek, F. W.G.

AU - Ouwendijk, R. J.Th

AU - Kolk, A. H.J.

AU - Dees, A.

AU - Meek, J. Ch E.

AU - Nienhuis, J. E.

AU - Dingemans-Dumas, A. M.

PY - 1996/4/1

Y1 - 1996/4/1

N2 - Background - Bladder instillations with Bacillus Calmette-Guerin (BCG) are commonly used as immunotherapy for bladder carcinoma. Sometimes patients experience serious systemic side effects, such as sepsis or pneumonitis. Granulomatous hepatitis is a rare serious side effect, which has been considered a hypersensitivity reaction to BCG. Patient - The first case of granulomatous hepatitis after BCG bladder instillation in which mycobacteria were identified by staining techniques and mycobacterial DNA was detected in liver tissue using the polymerase chain reaction is reported. Conclusion - The granulomatous hepatitis was caused by BCG infection of the liver after haematogenous dissemination of BCG, rather than hypersensitivity.

AB - Background - Bladder instillations with Bacillus Calmette-Guerin (BCG) are commonly used as immunotherapy for bladder carcinoma. Sometimes patients experience serious systemic side effects, such as sepsis or pneumonitis. Granulomatous hepatitis is a rare serious side effect, which has been considered a hypersensitivity reaction to BCG. Patient - The first case of granulomatous hepatitis after BCG bladder instillation in which mycobacteria were identified by staining techniques and mycobacterial DNA was detected in liver tissue using the polymerase chain reaction is reported. Conclusion - The granulomatous hepatitis was caused by BCG infection of the liver after haematogenous dissemination of BCG, rather than hypersensitivity.

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DO - 10.1136/gut.38.4.616

M3 - Article

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AN - SCOPUS:0029940618

SN - 0017-5749

VL - 38

SP - 616

EP - 618

JO - Gut

JF - Gut

IS - 4

ER -

Granulomatous hepatitis caused by bacillus Calmette-Guerin (BCG) infection after BCG bladder instillation

Abstract

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