Guidance for chest-CT in children and adults with cystic fibrosis: A European perspective

Michael Fayon; Kate Hill; Michael Waldron; Barbara Messore; Luca Riberi; Marcus Svedberg; Elise Lammertyn; Stojka Fustik; Andrea Gramegna; Mirjam Stahl; Anna Kerpel-Fronius; Maurizio Balbi; Pierluigi Ciet; Guillaume Chassagnon; Cinzia Ferrero; Pierre Régis Burgel; Sivagurunathan Sutharsan; Marcel Opitz; Eleni Rosalina Andrinopoulou; Gael Dournes; Michael Maher; Jamie Duckers; Harm Tiddens; Isabelle Sermet

doi:10.1016/j.rmed.2025.108076

Guidance for chest-CT in children and adults with cystic fibrosis: A European perspective

Michael Fayon^*, Kate Hill^*, Michael Waldron, Barbara Messore, Luca Riberi, Marcus Svedberg, Elise Lammertyn, Stojka Fustik, Andrea Gramegna, Mirjam Stahl, Anna Kerpel-Fronius, Maurizio Balbi, Pierluigi Ciet, Guillaume Chassagnon, Cinzia Ferrero, Pierre Régis Burgel, Sivagurunathan Sutharsan, Marcel Opitz, Eleni Rosalina Andrinopoulou, Gael DournesMichael Maher, Jamie Duckers, Harm Tiddens, Isabelle Sermet

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

The European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN) herein proposes guidance for the use of chest CT-scans for the regular monitoring of lung disease in CF. Statements were completed in a 3-step process: the questions were identified via an anonymous online survey, followed by a comprehensive literature search, and a final Delphi process. The guidance recommends the use of ultra-low dose CT scans (effective radiation dose, 0.08 mSv; equivalent to 2 to 4 chest X-rays), tracking of patients' cumulative radiation and effective communication strategies using “de-medicalized” information for shared decision making. Chest CT scans (with lung volume monitoring) are not recommended systematically in both children and adults. Ultimate responsibility for justifying a chest CT scan lies with the individual professionals directly involved, the final decision being influenced by indications, costs, expertise, available material, resources and/or the patient's values, as well as possible impact on treatment modalities.

Original language	English
Article number	108076
Journal	Respiratory Medicine
Volume	241
DOIs	https://doi.org/10.1016/j.rmed.2025.108076
Publication status	Published - May 2025

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© 2025 The Authors

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Guidance for chest-CT in children and adults with cystic fibrosisFinal published version, 1.01 MBLicence: CC BY

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Fayon, M., Hill, K., Waldron, M., Messore, B., Riberi, L., Svedberg, M., Lammertyn, E., Fustik, S., Gramegna, A., Stahl, M., Kerpel-Fronius, A., Balbi, M., Ciet, P., Chassagnon, G., Ferrero, C., Burgel, P. R., Sutharsan, S., Opitz, M., Andrinopoulou, E. R., ... Sermet, I. (2025). Guidance for chest-CT in children and adults with cystic fibrosis: A European perspective. Respiratory Medicine, 241, Article 108076. https://doi.org/10.1016/j.rmed.2025.108076

@article{14b0cdb88a524eecac73df54d6041a29,

title = "Guidance for chest-CT in children and adults with cystic fibrosis: A European perspective",

abstract = "The European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN) herein proposes guidance for the use of chest CT-scans for the regular monitoring of lung disease in CF. Statements were completed in a 3-step process: the questions were identified via an anonymous online survey, followed by a comprehensive literature search, and a final Delphi process. The guidance recommends the use of ultra-low dose CT scans (effective radiation dose, 0.08 mSv; equivalent to 2 to 4 chest X-rays), tracking of patients' cumulative radiation and effective communication strategies using “de-medicalized” information for shared decision making. Chest CT scans (with lung volume monitoring) are not recommended systematically in both children and adults. Ultimate responsibility for justifying a chest CT scan lies with the individual professionals directly involved, the final decision being influenced by indications, costs, expertise, available material, resources and/or the patient's values, as well as possible impact on treatment modalities.",

author = "Michael Fayon and Kate Hill and Michael Waldron and Barbara Messore and Luca Riberi and Marcus Svedberg and Elise Lammertyn and Stojka Fustik and Andrea Gramegna and Mirjam Stahl and Anna Kerpel-Fronius and Maurizio Balbi and Pierluigi Ciet and Guillaume Chassagnon and Cinzia Ferrero and Burgel, {Pierre R{\'e}gis} and Sivagurunathan Sutharsan and Marcel Opitz and Andrinopoulou, {Eleni Rosalina} and Gael Dournes and Michael Maher and Jamie Duckers and Harm Tiddens and Isabelle Sermet",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = may,

doi = "10.1016/j.rmed.2025.108076",

language = "English",

volume = "241",

journal = "Respiratory Medicine",

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Fayon, M, Hill, K, Waldron, M, Messore, B, Riberi, L, Svedberg, M, Lammertyn, E, Fustik, S, Gramegna, A, Stahl, M, Kerpel-Fronius, A, Balbi, M, Ciet, P, Chassagnon, G, Ferrero, C, Burgel, PR, Sutharsan, S, Opitz, M, Andrinopoulou, ER, Dournes, G, Maher, M, Duckers, J, Tiddens, H & Sermet, I 2025, 'Guidance for chest-CT in children and adults with cystic fibrosis: A European perspective', Respiratory Medicine, vol. 241, 108076. https://doi.org/10.1016/j.rmed.2025.108076

TY - JOUR

T1 - Guidance for chest-CT in children and adults with cystic fibrosis

T2 - A European perspective

AU - Fayon, Michael

AU - Hill, Kate

AU - Waldron, Michael

AU - Messore, Barbara

AU - Riberi, Luca

AU - Svedberg, Marcus

AU - Lammertyn, Elise

AU - Fustik, Stojka

AU - Gramegna, Andrea

AU - Stahl, Mirjam

AU - Kerpel-Fronius, Anna

AU - Balbi, Maurizio

AU - Ciet, Pierluigi

AU - Chassagnon, Guillaume

AU - Ferrero, Cinzia

AU - Burgel, Pierre Régis

AU - Sutharsan, Sivagurunathan

AU - Opitz, Marcel

AU - Andrinopoulou, Eleni Rosalina

AU - Dournes, Gael

AU - Maher, Michael

AU - Duckers, Jamie

AU - Tiddens, Harm

AU - Sermet, Isabelle

PY - 2025/5

Y1 - 2025/5

N2 - The European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN) herein proposes guidance for the use of chest CT-scans for the regular monitoring of lung disease in CF. Statements were completed in a 3-step process: the questions were identified via an anonymous online survey, followed by a comprehensive literature search, and a final Delphi process. The guidance recommends the use of ultra-low dose CT scans (effective radiation dose, 0.08 mSv; equivalent to 2 to 4 chest X-rays), tracking of patients' cumulative radiation and effective communication strategies using “de-medicalized” information for shared decision making. Chest CT scans (with lung volume monitoring) are not recommended systematically in both children and adults. Ultimate responsibility for justifying a chest CT scan lies with the individual professionals directly involved, the final decision being influenced by indications, costs, expertise, available material, resources and/or the patient's values, as well as possible impact on treatment modalities.

AB - The European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN) herein proposes guidance for the use of chest CT-scans for the regular monitoring of lung disease in CF. Statements were completed in a 3-step process: the questions were identified via an anonymous online survey, followed by a comprehensive literature search, and a final Delphi process. The guidance recommends the use of ultra-low dose CT scans (effective radiation dose, 0.08 mSv; equivalent to 2 to 4 chest X-rays), tracking of patients' cumulative radiation and effective communication strategies using “de-medicalized” information for shared decision making. Chest CT scans (with lung volume monitoring) are not recommended systematically in both children and adults. Ultimate responsibility for justifying a chest CT scan lies with the individual professionals directly involved, the final decision being influenced by indications, costs, expertise, available material, resources and/or the patient's values, as well as possible impact on treatment modalities.

UR - http://www.scopus.com/inward/record.url?scp=105002050790&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2025.108076

DO - 10.1016/j.rmed.2025.108076

M3 - Review article

C2 - 40189162

AN - SCOPUS:105002050790

SN - 0954-6111

VL - 241

JO - Respiratory Medicine

JF - Respiratory Medicine

M1 - 108076

ER -

Guidance for chest-CT in children and adults with cystic fibrosis: A European perspective

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