TY - JOUR
T1 - Guillain-Barré Syndrome in Suriname; Clinical Presentation and Identification of Preceding Infections
AU - Langerak, Thomas
AU - Rooij, Irene
AU - Doornekamp, Laura
AU - Chandler, Felicity
AU - Baptista, M
AU - Yang, H
AU - Koopmans, Marion
AU - Geurts van Kessel, Corine
AU - Jacobs, B.C.
AU - Rockx, Barry
AU - Adriani, Kirsten
AU - van Gorp, Eric
N1 - Publisher Copyright:
© Copyright © 2021 Langerak, van Rooij, Doornekamp, Chandler, Baptista, Yang, Koopmans, GeurtsvanKessel, Jacobs, Rockx, Adriani and van Gorp.
PY - 2021/2/10
Y1 - 2021/2/10
N2 - Guillain-Barré syndrome (GBS) is associated with various types of preceding infections including Campylobacter jejuni and cytomegalovirus, but there is also an association with arthropod borne viruses (arboviruses), such as Zika virus, that are endemic in tropical regions. Here we present the clinical characteristics of 12 GBS patients from Suriname that were hospitalized between the beginning of 2016 and half 2018. Extensive diagnostic testing was performed for pathogens that are commonly associated with GBS, but also for arboviruses, in order to identify the preceding infection that might have led to GBS. With this extensive testing algorithm, we could identify a recent infection in six patients of which four of them had evidence of a recent Zika virus or dengue virus infection. These results suggest that arboviruses, specifically Zika virus but possibly also dengue virus, might be important causative agents of GBS in Suriname. Furthermore, we found that more accessibility of intravenous immunoglobulins or plasma exchange could improve the treatment of GBS in Suriname.
AB - Guillain-Barré syndrome (GBS) is associated with various types of preceding infections including Campylobacter jejuni and cytomegalovirus, but there is also an association with arthropod borne viruses (arboviruses), such as Zika virus, that are endemic in tropical regions. Here we present the clinical characteristics of 12 GBS patients from Suriname that were hospitalized between the beginning of 2016 and half 2018. Extensive diagnostic testing was performed for pathogens that are commonly associated with GBS, but also for arboviruses, in order to identify the preceding infection that might have led to GBS. With this extensive testing algorithm, we could identify a recent infection in six patients of which four of them had evidence of a recent Zika virus or dengue virus infection. These results suggest that arboviruses, specifically Zika virus but possibly also dengue virus, might be important causative agents of GBS in Suriname. Furthermore, we found that more accessibility of intravenous immunoglobulins or plasma exchange could improve the treatment of GBS in Suriname.
UR - http://www.scopus.com/inward/record.url?scp=85101600783&partnerID=8YFLogxK
U2 - 10.3389/fneur.2021.635753
DO - 10.3389/fneur.2021.635753
M3 - Article
C2 - 33643209
SN - 1664-2295
VL - 12
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 635753
ER -
