GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

N Franceschini; C Giambartolomei; PS de Vries; C Finan; JC Bis; RP Huntley; RC Lovering; S M Tajuddin; TW Winkler; M Graff; Maryam Kavousi; C Dale; AV Smith; E Hofer; Elisa Leeuwen; IM Nolte; LY Lu; M Scholz; M Sargurupremraj; N Pitkanen; O Franzen; PK Joshi; R Noordam; RE Marioni; SJ Hwang; SK Musani; U Schminke; W Palmas; Aaron Isaacs; A Correa; AB Zonderman; Amy Hofman; A Teumer; A J Cox; André Uitterlinden; A Wong; AJ Smit; AB Newman; A Britton; A Ruusalepp; B Sennblad; B Hedblad; B Pasaniuc; BW Penninx; CD Langefeld; CL Wassel; C Tzourio; C Fava; D Baldassarre; DH O'Leary; D Teupser; D Kuh; E Tremoli; E Mannarino; E Grossi; E Boerwinkle; EE Schadt; E Ingelsson; F Veglia; Fernando Rivadeneira; F Beutner; G Chauhan; G Heiss; H Snieder; H Campbell; H Volzke; HS Markus; IJ Deary; JW Jukema; J Graaf; J Price; J Pott; JC Hopewell; JJ Liang; J Thiery; J Engmann; K Gertow; K Rice; KD Taylor; K Dhana; L Kiemeney; L Lind; L M Raffield; LJ Launer; LM Holdt; M Dorr; M Dichgans; M Traylor; M Sitzer; M Kumari; M Kivimaki; MA Nalls; O Melander; O Raitakari; OH Franco Duran; Oscar Rueda Ochoa; P Roussos; PH Whincup; P Amouyel; P Giral; P Anugu; Q Wong; R Malik; R Rauramaa; R Burkhardt; R Hardy; R Schmidt; R de Mutsert; RW Morris; RJ Strawbridge; SG Wannamethee; S Hagg; S Shah; S McLachlan; S Trompet; S Seshadri; S Kurl; SR Heckbert; S Ring; TB Harris; T Lehtimaki; TE Galesloot; T Shah; U de Faire; V Plagnol; WD Rosamond; W Post; XF Zhu; XL Zhang; XQ Guo; Y Saba; Abbas Dehghan; A Seldenrijk; AC Morrison; A Hamsten; BM Psaty; Cornelia Duijn; DA Lawlor; Dennis Mook; DW Bowden; H Schmidt; JF Wilson; JG Wilson; JI Rotter; JM Wardlaw; J Deanfield; J Halcox; LP Lyytikainen; M Loeffler; MK Evans; S Debette; SE Humphries; U Volker; V Gudnason; AD Hingorani; JLM Bjorkegren; JP Casas; CJ O'Donnell

doi:10.1038/s41467-018-07340-5

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

N Franceschini, C Giambartolomei, PS de Vries, C Finan, JC Bis, RP Huntley, RC Lovering, S M Tajuddin, TW Winkler, M Graff, Maryam Kavousi, C Dale, AV Smith, E Hofer, Elisa Leeuwen, IM Nolte, LY Lu, M Scholz, M Sargurupremraj, N PitkanenO Franzen, PK Joshi, R Noordam, RE Marioni, SJ Hwang, SK Musani, U Schminke, W Palmas, Aaron Isaacs, A Correa, AB Zonderman, Amy Hofman, A Teumer, A J Cox, André Uitterlinden, A Wong, AJ Smit, AB Newman, A Britton, A Ruusalepp, B Sennblad, B Hedblad, B Pasaniuc, BW Penninx, CD Langefeld, CL Wassel, C Tzourio, C Fava, D Baldassarre, DH O'Leary, D Teupser, D Kuh, E Tremoli, E Mannarino, E Grossi, E Boerwinkle, EE Schadt, E Ingelsson, F Veglia, Fernando Rivadeneira, F Beutner, G Chauhan, G Heiss, H Snieder, H Campbell, H Volzke, HS Markus, IJ Deary, JW Jukema, J Graaf, J Price, J Pott, JC Hopewell, JJ Liang, J Thiery, J Engmann, K Gertow, K Rice, KD Taylor, K Dhana, L Kiemeney, L Lind, L M Raffield, LJ Launer, LM Holdt, M Dorr, M Dichgans, M Traylor, M Sitzer, M Kumari, M Kivimaki, MA Nalls, O Melander, O Raitakari, OH Franco Duran, Oscar Rueda Ochoa, P Roussos, PH Whincup, P Amouyel, P Giral, P Anugu, Q Wong, R Malik, R Rauramaa, R Burkhardt, R Hardy, R Schmidt, R de Mutsert, RW Morris, RJ Strawbridge, SG Wannamethee, S Hagg, S Shah, S McLachlan, S Trompet, S Seshadri, S Kurl, SR Heckbert, S Ring, TB Harris, T Lehtimaki, TE Galesloot, T Shah, U de Faire, V Plagnol, WD Rosamond, W Post, XF Zhu, XL Zhang, XQ Guo, Y Saba, Abbas Dehghan, A Seldenrijk, AC Morrison, A Hamsten, BM Psaty, Cornelia Duijn, DA Lawlor, Dennis Mook, DW Bowden, H Schmidt, JF Wilson, JG Wilson, JI Rotter, JM Wardlaw, J Deanfield, J Halcox, LP Lyytikainen, M Loeffler, MK Evans, S Debette, SE Humphries, U Volker, V Gudnason, AD Hingorani, JLM Bjorkegren, JP Casas, CJ O'Donnell

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Original language	Undefined/Unknown
Article number	5141
Journal	Nature Communications
Volume	9
DOIs	https://doi.org/10.1038/s41467-018-07340-5
Publication status	Published - 2018

Research programs

EMC MM-01-39-09-A
EMC NIHES-01-64-02

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10.1038/s41467-018-07340-5

Repub_112872_O-A.pdfFinal published version, 1.63 MB

http://hdl.handle.net/1765/112872

Cite this

Franceschini, N., Giambartolomei, C., de Vries, PS., Finan, C., Bis, JC., Huntley, RP., Lovering, RC., Tajuddin, S. M., Winkler, TW., Graff, M., Kavousi, M., Dale, C., Smith, AV., Hofer, E., Leeuwen, E., Nolte, IM., Lu, LY., Scholz, M., Sargurupremraj, M., ... O'Donnell, CJ. (2018). GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nature Communications, 9, Article 5141. https://doi.org/10.1038/s41467-018-07340-5

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title = "GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes",

author = "N Franceschini and C Giambartolomei and {de Vries}, PS and C Finan and JC Bis and RP Huntley and RC Lovering and Tajuddin, {S M} and TW Winkler and M Graff and Maryam Kavousi and C Dale and AV Smith and E Hofer and Elisa Leeuwen and IM Nolte and LY Lu and M Scholz and M Sargurupremraj and N Pitkanen and O Franzen and PK Joshi and R Noordam and RE Marioni and SJ Hwang and SK Musani and U Schminke and W Palmas and Aaron Isaacs and A Correa and AB Zonderman and Amy Hofman and A Teumer and Cox, {A J} and Andr{\'e} Uitterlinden and A Wong and AJ Smit and AB Newman and A Britton and A Ruusalepp and B Sennblad and B Hedblad and B Pasaniuc and BW Penninx and CD Langefeld and CL Wassel and C Tzourio and C Fava and D Baldassarre and DH O'Leary and D Teupser and D Kuh and E Tremoli and E Mannarino and E Grossi and E Boerwinkle and EE Schadt and E Ingelsson and F Veglia and Fernando Rivadeneira and F Beutner and G Chauhan and G Heiss and H Snieder and H Campbell and H Volzke and HS Markus and IJ Deary and JW Jukema and J Graaf and J Price and J Pott and JC Hopewell and JJ Liang and J Thiery and J Engmann and K Gertow and K Rice and KD Taylor and K Dhana and L Kiemeney and L Lind and Raffield, {L M} and LJ Launer and LM Holdt and M Dorr and M Dichgans and M Traylor and M Sitzer and M Kumari and M Kivimaki and MA Nalls and O Melander and O Raitakari and {Franco Duran}, OH and {Rueda Ochoa}, Oscar and P Roussos and PH Whincup and P Amouyel and P Giral and P Anugu and Q Wong and R Malik and R Rauramaa and R Burkhardt and R Hardy and R Schmidt and {de Mutsert}, R and RW Morris and RJ Strawbridge and SG Wannamethee and S Hagg and S Shah and S McLachlan and S Trompet and S Seshadri and S Kurl and SR Heckbert and S Ring and TB Harris and T Lehtimaki and TE Galesloot and T Shah and {de Faire}, U and V Plagnol and WD Rosamond and W Post and XF Zhu and XL Zhang and XQ Guo and Y Saba and Abbas Dehghan and A Seldenrijk and AC Morrison and A Hamsten and BM Psaty and Cornelia Duijn and DA Lawlor and Dennis Mook and DW Bowden and H Schmidt and JF Wilson and JG Wilson and JI Rotter and JM Wardlaw and J Deanfield and J Halcox and LP Lyytikainen and M Loeffler and MK Evans and S Debette and SE Humphries and U Volker and V Gudnason and AD Hingorani and JLM Bjorkegren and JP Casas and CJ O'Donnell",

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language = "Undefined/Unknown",

volume = "9",

journal = "Nature Communications",

issn = "2041-1723",

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Franceschini, N, Giambartolomei, C, de Vries, PS, Finan, C, Bis, JC, Huntley, RP, Lovering, RC, Tajuddin, SM, Winkler, TW, Graff, M, Kavousi, M, Dale, C, Smith, AV, Hofer, E, Leeuwen, E, Nolte, IM, Lu, LY, Scholz, M, Sargurupremraj, M, Pitkanen, N, Franzen, O, Joshi, PK, Noordam, R, Marioni, RE, Hwang, SJ, Musani, SK, Schminke, U, Palmas, W, Isaacs, A, Correa, A, Zonderman, AB, Hofman, A, Teumer, A, Cox, AJ, Uitterlinden, A, Wong, A, Smit, AJ, Newman, AB, Britton, A, Ruusalepp, A, Sennblad, B, Hedblad, B, Pasaniuc, B, Penninx, BW, Langefeld, CD, Wassel, CL, Tzourio, C, Fava, C, Baldassarre, D, O'Leary, DH, Teupser, D, Kuh, D, Tremoli, E, Mannarino, E, Grossi, E, Boerwinkle, E, Schadt, EE, Ingelsson, E, Veglia, F, Rivadeneira, F, Beutner, F, Chauhan, G, Heiss, G, Snieder, H, Campbell, H, Volzke, H, Markus, HS, Deary, IJ, Jukema, JW, Graaf, J, Price, J, Pott, J, Hopewell, JC, Liang, JJ, Thiery, J, Engmann, J, Gertow, K, Rice, K, Taylor, KD, Dhana, K, Kiemeney, L, Lind, L, Raffield, LM, Launer, LJ, Holdt, LM, Dorr, M, Dichgans, M, Traylor, M, Sitzer, M, Kumari, M, Kivimaki, M, Nalls, MA, Melander, O, Raitakari, O, Franco Duran, OH, Rueda Ochoa, O, Roussos, P, Whincup, PH, Amouyel, P, Giral, P, Anugu, P, Wong, Q, Malik, R, Rauramaa, R, Burkhardt, R, Hardy, R, Schmidt, R, de Mutsert, R, Morris, RW, Strawbridge, RJ, Wannamethee, SG, Hagg, S, Shah, S, McLachlan, S, Trompet, S, Seshadri, S, Kurl, S, Heckbert, SR, Ring, S, Harris, TB, Lehtimaki, T, Galesloot, TE, Shah, T, de Faire, U, Plagnol, V, Rosamond, WD, Post, W, Zhu, XF, Zhang, XL, Guo, XQ, Saba, Y, Dehghan, A, Seldenrijk, A, Morrison, AC, Hamsten, A, Psaty, BM, Duijn, C, Lawlor, DA, Mook, D, Bowden, DW, Schmidt, H, Wilson, JF, Wilson, JG, Rotter, JI, Wardlaw, JM, Deanfield, J, Halcox, J, Lyytikainen, LP, Loeffler, M, Evans, MK, Debette, S, Humphries, SE, Volker, U, Gudnason, V, Hingorani, AD, Bjorkegren, JLM, Casas, JP & O'Donnell, CJ 2018, 'GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes', Nature Communications, vol. 9, 5141. https://doi.org/10.1038/s41467-018-07340-5

TY - JOUR

T1 - GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

AU - Franceschini, N

AU - Giambartolomei, C

AU - de Vries, PS

AU - Finan, C

AU - Bis, JC

AU - Huntley, RP

AU - Lovering, RC

AU - Tajuddin, S M

AU - Winkler, TW

AU - Graff, M

AU - Kavousi, Maryam

AU - Dale, C

AU - Smith, AV

AU - Hofer, E

AU - Leeuwen, Elisa

AU - Nolte, IM

AU - Lu, LY

AU - Scholz, M

AU - Sargurupremraj, M

AU - Pitkanen, N

AU - Franzen, O

AU - Joshi, PK

AU - Noordam, R

AU - Marioni, RE

AU - Hwang, SJ

AU - Musani, SK

AU - Schminke, U

AU - Palmas, W

AU - Isaacs, Aaron

AU - Correa, A

AU - Zonderman, AB

AU - Hofman, Amy

AU - Teumer, A

AU - Cox, A J

AU - Uitterlinden, André

AU - Wong, A

AU - Smit, AJ

AU - Newman, AB

AU - Britton, A

AU - Ruusalepp, A

AU - Sennblad, B

AU - Hedblad, B

AU - Pasaniuc, B

AU - Penninx, BW

AU - Langefeld, CD

AU - Wassel, CL

AU - Tzourio, C

AU - Fava, C

AU - Baldassarre, D

AU - O'Leary, DH

AU - Teupser, D

AU - Kuh, D

AU - Tremoli, E

AU - Mannarino, E

AU - Grossi, E

AU - Boerwinkle, E

AU - Schadt, EE

AU - Ingelsson, E

AU - Veglia, F

AU - Rivadeneira, Fernando

AU - Beutner, F

AU - Chauhan, G

AU - Heiss, G

AU - Snieder, H

AU - Campbell, H

AU - Volzke, H

AU - Markus, HS

AU - Deary, IJ

AU - Jukema, JW

AU - Graaf, J

AU - Price, J

AU - Pott, J

AU - Hopewell, JC

AU - Liang, JJ

AU - Thiery, J

AU - Engmann, J

AU - Gertow, K

AU - Rice, K

AU - Taylor, KD

AU - Dhana, K

AU - Kiemeney, L

AU - Lind, L

AU - Raffield, L M

AU - Launer, LJ

AU - Holdt, LM

AU - Dorr, M

AU - Dichgans, M

AU - Traylor, M

AU - Sitzer, M

AU - Kumari, M

AU - Kivimaki, M

AU - Nalls, MA

AU - Melander, O

AU - Raitakari, O

AU - Franco Duran, OH

AU - Rueda Ochoa, Oscar

AU - Roussos, P

AU - Whincup, PH

AU - Amouyel, P

AU - Giral, P

AU - Anugu, P

AU - Wong, Q

AU - Malik, R

AU - Rauramaa, R

AU - Burkhardt, R

AU - Hardy, R

AU - Schmidt, R

AU - de Mutsert, R

AU - Morris, RW

AU - Strawbridge, RJ

AU - Wannamethee, SG

AU - Hagg, S

AU - Shah, S

AU - McLachlan, S

AU - Trompet, S

AU - Seshadri, S

AU - Kurl, S

AU - Heckbert, SR

AU - Ring, S

AU - Harris, TB

AU - Lehtimaki, T

AU - Galesloot, TE

AU - Shah, T

AU - de Faire, U

AU - Plagnol, V

AU - Rosamond, WD

AU - Post, W

AU - Zhu, XF

AU - Zhang, XL

AU - Guo, XQ

AU - Saba, Y

AU - Dehghan, Abbas

AU - Seldenrijk, A

AU - Morrison, AC

AU - Hamsten, A

AU - Psaty, BM

AU - Duijn, Cornelia

AU - Lawlor, DA

AU - Mook, Dennis

AU - Bowden, DW

AU - Schmidt, H

AU - Wilson, JF

AU - Wilson, JG

AU - Rotter, JI

AU - Wardlaw, JM

AU - Deanfield, J

AU - Halcox, J

AU - Lyytikainen, LP

AU - Loeffler, M

AU - Evans, MK

AU - Debette, S

AU - Humphries, SE

AU - Volker, U

AU - Gudnason, V

AU - Hingorani, AD

AU - Bjorkegren, JLM

AU - Casas, JP

AU - O'Donnell, CJ

PY - 2018

Y1 - 2018

U2 - 10.1038/s41467-018-07340-5

DO - 10.1038/s41467-018-07340-5

M3 - Article

C2 - 30510157

SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

M1 - 5141

ER -