Health-related Quality of Life using the EQ-5D-5L: normative utility scores in a Dutch female population

Marloes E. Clarijs*, Lindy M. Kregting, Nicolien T. van Ravesteyn, Linetta B. Koppert, Ida J. Korfage

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
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Purpose: Normative utility scores represent the health related quality of life of the general population, are of utmost importance in cost-effectiveness studies and should reflect relevant sexes and age groups. The aim of this study was to estimate EQ-5D-5L normative utility scores in a population of Dutch females, stratified by age, and to compare these scores to those of female populations of three other countries. Methods: Dutch women completed the EQ-5D-5L online between January and July 2020. Mean normative utilities were computed using the Dutch EQ-5D-5L value set, stratified by age, tested for differences using the Kruskall–Wallis test, and compared to normative utility scores of female populations elsewhere. Additionally, to support the use of the Dutch EQ-5D-5L data in other settings, normative utility scores were also calculated by applying the value sets of Germany, United Kingdom and USA. Results: Data of 9037 women were analyzed and the weighted mean utility score was 0.911 (SD 0.155, 95% CI 0.908–0.914). The mean normative utility scores differed between age groups, showing lower scores in older females. Compared to other normative utility scores of female populations, Dutch mean utilities were consistently higher except for age groups 18–24 and 25–34. With the three country-specific value sets, new age-specific mean normative utility scores were provided. Conclusion: This study provides mean normative utility scores of a large cohort of Dutch females per age group, which were found to be lower in older age groups. Utility scores calculated with three other value sets were made available.

Original languageEnglish
Pages (from-to)373-381
Number of pages9
JournalQuality of Life Research
Issue number2
Early online date20 Oct 2022
Publication statusPublished - Feb 2023

Bibliographical note

Funding Information:
The authors would like to thank all women who participated in this study.

Publisher Copyright:
© 2022, The Author(s).


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