Health-related quality of life with lisocabtagene maraleucel vs standard of care in relapsed or refractory LBCL

Jeremy S. Abramson*, Patrick B. Johnston, Manali Kamdar, Sami Ibrahimi, Koji Izutsu, Jon Arnason, Bertram Glass, Pim Mutsaers, Matthew Lunning, Julia Braverman, Fei Fei Liu, Alessandro Crotta, Sandrine Montheard, Alessandro Previtali, Shien Guo, Ling Shi, Scott R. Solomon

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Downloads (Pure)

Abstract

Lisocabtagene maraleucel (liso-cel) has shown promising efficacy in clinical trials for patients with relapsed/refractory large B-cell lymphoma (LBCL). We present health-related quality of life (HRQOL) results from the TRANSFORM study, the first comparative analysis of liso-cel vs standard of care (SOC) as second-line therapy in this population. Adults with LBCL refractory or relapsed ≤12 months after first-line therapy and eligible for autologous stem cell transplantation were randomized 1:1 to the liso-cel or SOC arms (3 cycles of immunochemotherapy in which responders proceeded to high-dose chemotherapy and autologous stem cell transplantation). HRQOL was assessed by European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire – 30 items and the Functional Assessment of Cancer Therapy-Lymphoma subscale. Patients with baseline and ≥1 postbaseline assessment were analyzed (liso-cel, n = 47; SOC, n = 43). The proportion of patients with meaningful improvement in global health status/quality of life (QOL) was higher, whereas deterioration was lower in the liso-cel arm vs SOC arm from day 126 to month 6. Mean change scores showed meaningful worsening in global health status/QOL at month 6, fatigue at day 29 and month 6, and pain at month 6 with SOC; mean scores for other domains were maintained or improved in both arms. Time to confirmed deterioration favored the liso-cel arm vs SOC arm in global health status/QOL (median: not reached vs 19.0 weeks, respectively; hazard ratio, 0.47; 95% confidence interval, 0.24-0.94). HRQOL was either improved or maintained from baseline in patients with relapsed/refractory LBCL in the liso-cel arm vs SOC arm as second-line treatment. This study is registered at clinicaltrials.gov as #NCT0357531.

Original languageEnglish
Pages (from-to)5969-5979
Number of pages11
JournalBlood advances
Volume6
Issue number23
DOIs
Publication statusPublished - 13 Dec 2022

Bibliographical note

Funding Information:
This study was funded by Celgene, a Bristol-Myers Squibb Company. Writing and editorial assistance were provided by Brooke Middlebrook, CMPP, of Evidera Inc. and Jeremy Henriques, PhD, CMPP, of the Lockwood Group (Stamford, CT), funded by Bristol Myers Squibb.

Publisher Copyright:
© 2022 by The American Society of Hematology.

Fingerprint

Dive into the research topics of 'Health-related quality of life with lisocabtagene maraleucel vs standard of care in relapsed or refractory LBCL'. Together they form a unique fingerprint.

Cite this