TY - JOUR
T1 - Hedgehog morphogen in cardiovascular disease
AU - Bijlsma, Maarten F.
AU - Peppelenbosch, Maikel P.
AU - Spek, C. Arnold
PY - 2006/10
Y1 - 2006/10
N2 - In this review, we focus on the basic biology of the important developmental Hedgehog (Hh) protein family, its general function in development, pathway mechanisms, and gene discovery and nomenclature. Hh function in cardiovascular development and recent findings concerning Hh signaling in ischemia models are discussed in more detail, and future perspectives are proposed. In light of the recent discovery of Hh transport by insect lipophorin, we also hypothesize a role for low-density lipoprotein (LDL) in mammalian Hh transport, creating a surprising role for LDL in cardiovascular disease.
AB - In this review, we focus on the basic biology of the important developmental Hedgehog (Hh) protein family, its general function in development, pathway mechanisms, and gene discovery and nomenclature. Hh function in cardiovascular development and recent findings concerning Hh signaling in ischemia models are discussed in more detail, and future perspectives are proposed. In light of the recent discovery of Hh transport by insect lipophorin, we also hypothesize a role for low-density lipoprotein (LDL) in mammalian Hh transport, creating a surprising role for LDL in cardiovascular disease.
UR - http://www.scopus.com/inward/record.url?scp=33750507716&partnerID=8YFLogxK
U2 - 10.1161/CIRCULATIONAHA.106.619213
DO - 10.1161/CIRCULATIONAHA.106.619213
M3 - Review article
C2 - 17075024
AN - SCOPUS:33750507716
SN - 0009-7322
VL - 114
SP - 1985
EP - 1991
JO - Circulation
JF - Circulation
IS - 18
ER -
