TY - JOUR
T1 - Hemoglobin levels and new-onset heart failure in the community
AU - Klip, Ijsbrand T.
AU - Postmus, Douwe
AU - Voors, Adriaan A.
AU - Brouwers, Frank P.J.
AU - Gansevoort, Ron T.
AU - Bakker, Stephan J.L.
AU - Hillege, Hans L.
AU - De Boer, Rudolf A.
AU - Van Der Harst, Pim
AU - Van Gilst, Wiek H.
AU - Van Veldhuisen, Dirk J.
AU - Van Der Meer, Peter
N1 - Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.
PY - 2015/1
Y1 - 2015/1
N2 - Background: In established cardiovascular disease and heart failure (HF), low hemoglobin levels are associated with unfavorable outcome.Whether hemoglobin levels are associated with the development of new-onset HF in the population is unclear. This study sought to investigate the relationship between hemoglobin levels and development of new-onset HF in the community. Methods: In 6,744 patients from PREVEND, a prospective, community-based, cohort study, we analyzed the relationship between hemoglobin levels and the risk of new-onset HF. Results: Mean age (±SD) was 53 ± 12 years, 49.8% was male, and mean hemoglobin level was 13.7 ± 1.2 g/dL. During a median follow-up of 8.3 years (interquartile range 7.8-8.9), 217 subjects (3.2%) were newly diagnosed with HF. The association between hemoglobin levels and the risk for new-onset HF was U shaped (Pb .001), remaining significant after full adjustment in a multivariablemodelwith established cardiovascular risk factors (P= .015). Furthermore, a increased annual HF incidencewas already observed in subjects with high-normal hemoglobin levels (men N16 g/dL or women N15 g/dL; P= .041), whereas on the other side of the distribution, only severe anemia (men b11 g/dL or women b10 g/dL; P= .018) was associated with a higher annual incidence. Conclusions: The impact of hemoglobin level on the risk of new-onset HF in the community is best described as U shaped. Interestingly, higher hemoglobin levels, already within the high-reference range, are associated with an increased incidence. This in contrast to anemia, where a higher annualHF incidence was only observed for severe anemia.
AB - Background: In established cardiovascular disease and heart failure (HF), low hemoglobin levels are associated with unfavorable outcome.Whether hemoglobin levels are associated with the development of new-onset HF in the population is unclear. This study sought to investigate the relationship between hemoglobin levels and development of new-onset HF in the community. Methods: In 6,744 patients from PREVEND, a prospective, community-based, cohort study, we analyzed the relationship between hemoglobin levels and the risk of new-onset HF. Results: Mean age (±SD) was 53 ± 12 years, 49.8% was male, and mean hemoglobin level was 13.7 ± 1.2 g/dL. During a median follow-up of 8.3 years (interquartile range 7.8-8.9), 217 subjects (3.2%) were newly diagnosed with HF. The association between hemoglobin levels and the risk for new-onset HF was U shaped (Pb .001), remaining significant after full adjustment in a multivariablemodelwith established cardiovascular risk factors (P= .015). Furthermore, a increased annual HF incidencewas already observed in subjects with high-normal hemoglobin levels (men N16 g/dL or women N15 g/dL; P= .041), whereas on the other side of the distribution, only severe anemia (men b11 g/dL or women b10 g/dL; P= .018) was associated with a higher annual incidence. Conclusions: The impact of hemoglobin level on the risk of new-onset HF in the community is best described as U shaped. Interestingly, higher hemoglobin levels, already within the high-reference range, are associated with an increased incidence. This in contrast to anemia, where a higher annualHF incidence was only observed for severe anemia.
UR - https://www.scopus.com/pages/publications/84925883468
U2 - 10.1016/j.ahj.2014.09.010
DO - 10.1016/j.ahj.2014.09.010
M3 - Article
C2 - 25497253
AN - SCOPUS:84925883468
SN - 0002-8703
VL - 169
SP - 94-101.e2
JO - American Heart Journal
JF - American Heart Journal
IS - 1
ER -
