Abstract
To the Editor:
The Case Records in the January 18 issue of the Journal 1 reflects the difficulties in distinguishing focal nodular hyperplasia from the fibrolamellar variant of hepatocellular carcinoma. Polysomies of chromosome 1, detected by conventional cytogenetic methods, may be characteristic of hepatocellular carcinoma.2,3 We used fluorescence in situ hybridization, a simple and rapid method that allows the detection of chromosomal aberrations in interphase nuclei, to investigate the number of copies of chromosome 1 in cytologic preparations of malignant and benign liver tumors. [...]
The Case Records in the January 18 issue of the Journal 1 reflects the difficulties in distinguishing focal nodular hyperplasia from the fibrolamellar variant of hepatocellular carcinoma. Polysomies of chromosome 1, detected by conventional cytogenetic methods, may be characteristic of hepatocellular carcinoma.2,3 We used fluorescence in situ hybridization, a simple and rapid method that allows the detection of chromosomal aberrations in interphase nuclei, to investigate the number of copies of chromosome 1 in cytologic preparations of malignant and benign liver tumors. [...]
| Original language | English |
|---|---|
| Pages (from-to) | 1478-1479 |
| Number of pages | 2 |
| Journal | New England Journal of Medicine |
| Volume | 334 |
| Issue number | 22 |
| DOIs |
|
| Publication status | Published - 30 May 1996 |
Fingerprint
Dive into the research topics of 'Hepatocellular carcinoma (Case 2-1996) [5]'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver