Hepatosplanchnic circulation in cirrhosis and sepsis

M Prin, Jan Bakker, G Wagener

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Abstract

Hepatosplanchnic circulation receives almost half of cardiac output and is essential to physiologic homeostasis. Liver cirrhosis is estimated to affect up to 1% of populations worldwide, including 1.5% to 3.3% of intensive care unit patients. Cirrhosis leads to hepatosplanchnic circulatory abnormalities and end-organ damage. Sepsis and cirrhosis result in similar circulatory changes and resultant multi-organ dysfunction. This review provides an overview of the hepatosplanchnic circulation in the healthy state and in cirrhosis, examines the signaling pathways that may play a role in the physiology of cirrhosis, discusses the physiology common to cirrhosis and sepsis, and reviews important issues in management.
Original languageUndefined/Unknown
Pages (from-to)2582-2592
Number of pages11
JournalWorld Journal of Gastroenterology
Volume21
Issue number9
DOIs
Publication statusPublished - 2015

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