Hereditary cerebral hemorrhage with amyloidosis Dutch type: A study of fibrinolysis

J. Haan, C. Kluft, F. W.G. Leebeek, A. C.W. De Bart, O. J.S. Buruma, R. A.C. Roos*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)


In view of reported associations between increased bleeding tendency and systemically decreased α2-antiplasmin in patients with systemic amyloid deposition we studied α2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with hereditary cerebral hemorrhage with amyloidosis - Dutch type (HCHWA-D). None of the factors measured in the quiescent phase of the disease was abnormal. In the acute phase, shortly after a stroke, only factor VIII:Ag was evidently elevated. We concluded that systemic abnormalities in the part of the fibrinolysis system studied are not likely to be responsible for multifocal and recurrent cerebral hemorrhages in HCHWA-D. The role of an elevated factor VIII: Ag level in the acute phase is unclear.

Original languageEnglish
Pages (from-to)16-18
Number of pages3
JournalThrombosis and Haemostasis
Issue number1
Publication statusPublished - 1992
Externally publishedYes


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