Herpes simplex infection in a juvenile orangutan (Pongo pygmaeus pygmaeus)

Maria J.L. Kik*, Jan H. Bos, Jan Groen, Gerry M. Dorresteijn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)


A juvenile orangutan (Pongo pygmaeus pygmaeus) died after 8 days of diarrhea and vomiting. Necropsy showed petechial hemorrhages in the skin, the myocardium, and the peritoneal membranes. The lungs were hyperemic and edematous, and the liver and spleen were enlarged. Histologic changes consisted of interstitial pneumonia, hepatitis, and splenic hyperplasia. Numerous eosinophilic intranuclear inclusion bodies were visible in pulmonary epithelial cells, hepatocytes, and splenic endothelial cells. Electron microscopic examination revealed herpesvirus in hepatocyte nuclei. Polymerase chain reaction of liver tissue demonstrated the presence of a herpes simplex virus-1.
Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalJournal of Zoo and Wildlife Medicine
Issue number1
Publication statusPublished - 1 Mar 2005

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  • EMC MM-04-27-01


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