Het idiopathisch mestcelactivatiesyndroom

Paul L.A. van Daele; Maud A.W. Hermans; J. Hanneke N.G. Oude Elberink; Roy Gerth van Wijk

Het idiopathisch mestcelactivatiesyndroom

Translated title of the contribution: Idiopathic mast cell activation syndrome

Paul L.A. van Daele^*
, Maud A.W. Hermans
, J. Hanneke N.G. Oude Elberink
, Roy Gerth van Wijk

^*Corresponding author for this work

University Medical Centre Groningen

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Idiopathic mast cell activation syndrome (MCAS) is one of the causes for recurrent complaints. The diagnosis is sometimes delayed but also often made incorrectly. CASE: Our patient presented with recurrent attacks of itching, redness of the skin, diarrhea and near collapse. During an attack his serum tryptase level rose significantly. We could not identify an underlying trigger. A diagnosis of idiopathic mast cell activation syndrome was made. He was successfully treated with a combination of H1 and H2 blockade. CONCLUSION: MCAS is characterized by recurrent complaints. To make the diagnosis a significant rise in mast cell mediators is required. Given the diversity of symptoms many patients with somatically unexplained symptoms wrongfully believe to be suffering from MCAS.

Translated title of the contribution	Idiopathic mast cell activation syndrome
Original language	Dutch
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	166
Publication status	Published - 24 Jan 2022

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title = "Het idiopathisch mestcelactivatiesyndroom",

abstract = "BACKGROUND: Idiopathic mast cell activation syndrome (MCAS) is one of the causes for recurrent complaints. The diagnosis is sometimes delayed but also often made incorrectly. CASE: Our patient presented with recurrent attacks of itching, redness of the skin, diarrhea and near collapse. During an attack his serum tryptase level rose significantly. We could not identify an underlying trigger. A diagnosis of idiopathic mast cell activation syndrome was made. He was successfully treated with a combination of H1 and H2 blockade. CONCLUSION: MCAS is characterized by recurrent complaints. To make the diagnosis a significant rise in mast cell mediators is required. Given the diversity of symptoms many patients with somatically unexplained symptoms wrongfully believe to be suffering from MCAS.",

author = "\{van Daele\}, \{Paul L.A.\} and Hermans, \{Maud A.W.\} and \{Oude Elberink\}, \{J. Hanneke N.G.\} and \{van Wijk\}, \{Roy Gerth\}",

year = "2022",

month = jan,

day = "24",

language = "Dutch",

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journal = "Nederlands Tijdschrift voor Geneeskunde",

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T1 - Het idiopathisch mestcelactivatiesyndroom

AU - van Daele, Paul L.A.

AU - Hermans, Maud A.W.

AU - Oude Elberink, J. Hanneke N.G.

AU - van Wijk, Roy Gerth

PY - 2022/1/24

Y1 - 2022/1/24

N2 - BACKGROUND: Idiopathic mast cell activation syndrome (MCAS) is one of the causes for recurrent complaints. The diagnosis is sometimes delayed but also often made incorrectly. CASE: Our patient presented with recurrent attacks of itching, redness of the skin, diarrhea and near collapse. During an attack his serum tryptase level rose significantly. We could not identify an underlying trigger. A diagnosis of idiopathic mast cell activation syndrome was made. He was successfully treated with a combination of H1 and H2 blockade. CONCLUSION: MCAS is characterized by recurrent complaints. To make the diagnosis a significant rise in mast cell mediators is required. Given the diversity of symptoms many patients with somatically unexplained symptoms wrongfully believe to be suffering from MCAS.

AB - BACKGROUND: Idiopathic mast cell activation syndrome (MCAS) is one of the causes for recurrent complaints. The diagnosis is sometimes delayed but also often made incorrectly. CASE: Our patient presented with recurrent attacks of itching, redness of the skin, diarrhea and near collapse. During an attack his serum tryptase level rose significantly. We could not identify an underlying trigger. A diagnosis of idiopathic mast cell activation syndrome was made. He was successfully treated with a combination of H1 and H2 blockade. CONCLUSION: MCAS is characterized by recurrent complaints. To make the diagnosis a significant rise in mast cell mediators is required. Given the diversity of symptoms many patients with somatically unexplained symptoms wrongfully believe to be suffering from MCAS.

UR - https://www.scopus.com/pages/publications/85124233952

M3 - Article

C2 - 35129899

AN - SCOPUS:85124233952

SN - 0028-2162

VL - 166

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

ER -

Het idiopathisch mestcelactivatiesyndroom

Abstract

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