HEV prevalence and potential risk factors in a large multi-ethnic youth cohort in China

Huixia Li; Yinxia Zhang; Zhongren Ma; Zewen Liu; Aqsa Ikram; Lijiang Liu; Guoqin Zhao; Northwest University; Zulqarnain Baloch

doi:10.1186/s12985-020-01470-3

HEV prevalence and potential risk factors in a large multi-ethnic youth cohort in China

Huixia Li, Yinxia Zhang, Zhongren Ma, Zewen Liu, Aqsa Ikram, Lijiang Liu, Guoqin Zhao, Northwest University, Zulqarnain Baloch^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

6 Downloads (Pure)

Abstract

Background: This cohort study was designed to investigate the prevalence of and potential risk factors of HEV infection in a large multi-ethnic youth cohort in China. Methods: Blood samples were collected from participants (n = 6269) and serum was isolated. All serum samples were tested for anti-HEV IgG, anti-HEV IgM antibodies using commercial enzyme immunoassay kits (Wantai Biological Pharmacy Enterprise, Beijing, China). Results: The overall rate of anti-HEV IgG and anti-HEV IgM prevalence was 4.78% and 0.14%, 0.03% were positive for both anti-HEV IgG and anti-HEV IgM antibodies. Anti-HEV IgG positivity is significantly higher in females (5.27%) compared to males (4.14%) (P = 0.028). Anti-HEV IgG prevalence is significantly (P = 0.0001) higher in Dong (17.57%), Miao (12.23%), Yi (11.04%), Gelao (9.76%), and Bai (10.00%) compared to other ethnic groups. It is significantly higher in Guizhou (11.4%), Sichuan (10.1%), Yunnan (9.3%), and Guangxi (6.9%) than that other province. We found that ethnicity and provincial background are significantly associated with HEV infection in this cohort. Conclusion: This study provides comprehensive information on HEV prevalence in multi-ethnic populations in China. However, our study only focused on a youth population from different provinces of China. Future studies are recommended to investigate HEV prevalence in other age groups of the ethnic populations.

Original language	English
Article number	3
Journal	Virology Journal
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12985-020-01470-3
Publication status	E-pub ahead of print - 6 Jan 2021
Externally published	Yes

Bibliographical note

Funding Information:
The work was supported by the Ministry of Education of China for an Innovative Research Team in University grant (No. IRT_17R88; to Z.M.) and the Fundamental Research Funds for the Central Universities (No. 31920200072). Funders has no role in the design of the study and collection, analysis, and interpretation of data, writing and publishing the manuscript.

Publisher Copyright:
© 2021, The Author(s).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12985-020-01470-3Licence: CC BY

s12985-020-01470-3Licence: CC BY

Cite this

@article{3feaea874acd400386ce8f343c2cf76b,

title = "HEV prevalence and potential risk factors in a large multi-ethnic youth cohort in China",

abstract = "Background: This cohort study was designed to investigate the prevalence of and potential risk factors of HEV infection in a large multi-ethnic youth cohort in China. Methods: Blood samples were collected from participants (n = 6269) and serum was isolated. All serum samples were tested for anti-HEV IgG, anti-HEV IgM antibodies using commercial enzyme immunoassay kits (Wantai Biological Pharmacy Enterprise, Beijing, China). Results: The overall rate of anti-HEV IgG and anti-HEV IgM prevalence was 4.78% and 0.14%, 0.03% were positive for both anti-HEV IgG and anti-HEV IgM antibodies. Anti-HEV IgG positivity is significantly higher in females (5.27%) compared to males (4.14%) (P = 0.028). Anti-HEV IgG prevalence is significantly (P = 0.0001) higher in Dong (17.57%), Miao (12.23%), Yi (11.04%), Gelao (9.76%), and Bai (10.00%) compared to other ethnic groups. It is significantly higher in Guizhou (11.4%), Sichuan (10.1%), Yunnan (9.3%), and Guangxi (6.9%) than that other province. We found that ethnicity and provincial background are significantly associated with HEV infection in this cohort. Conclusion: This study provides comprehensive information on HEV prevalence in multi-ethnic populations in China. However, our study only focused on a youth population from different provinces of China. Future studies are recommended to investigate HEV prevalence in other age groups of the ethnic populations.",

author = "Huixia Li and Yinxia Zhang and Zhongren Ma and Zewen Liu and Aqsa Ikram and Lijiang Liu and Guoqin Zhao and Northwest University and Zulqarnain Baloch",

note = "Funding Information: The work was supported by the Ministry of Education of China for an Innovative Research Team in University grant (No. IRT_17R88; to Z.M.) and the Fundamental Research Funds for the Central Universities (No. 31920200072). Funders has no role in the design of the study and collection, analysis, and interpretation of data, writing and publishing the manuscript. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = jan,

day = "6",

doi = "10.1186/s12985-020-01470-3",

language = "English",

volume = "18",

journal = "Virology Journal",

issn = "1743-422X",

publisher = "BioMed Central Ltd.",

number = "1",

}

TY - JOUR

T1 - HEV prevalence and potential risk factors in a large multi-ethnic youth cohort in China

AU - Li, Huixia

AU - Zhang, Yinxia

AU - Ma, Zhongren

AU - Liu, Zewen

AU - Ikram, Aqsa

AU - Liu, Lijiang

AU - Zhao, Guoqin

AU - University, Northwest

AU - Baloch, Zulqarnain

N1 - Funding Information: The work was supported by the Ministry of Education of China for an Innovative Research Team in University grant (No. IRT_17R88; to Z.M.) and the Fundamental Research Funds for the Central Universities (No. 31920200072). Funders has no role in the design of the study and collection, analysis, and interpretation of data, writing and publishing the manuscript. Publisher Copyright: © 2021, The Author(s).

PY - 2021/1/6

Y1 - 2021/1/6

N2 - Background: This cohort study was designed to investigate the prevalence of and potential risk factors of HEV infection in a large multi-ethnic youth cohort in China. Methods: Blood samples were collected from participants (n = 6269) and serum was isolated. All serum samples were tested for anti-HEV IgG, anti-HEV IgM antibodies using commercial enzyme immunoassay kits (Wantai Biological Pharmacy Enterprise, Beijing, China). Results: The overall rate of anti-HEV IgG and anti-HEV IgM prevalence was 4.78% and 0.14%, 0.03% were positive for both anti-HEV IgG and anti-HEV IgM antibodies. Anti-HEV IgG positivity is significantly higher in females (5.27%) compared to males (4.14%) (P = 0.028). Anti-HEV IgG prevalence is significantly (P = 0.0001) higher in Dong (17.57%), Miao (12.23%), Yi (11.04%), Gelao (9.76%), and Bai (10.00%) compared to other ethnic groups. It is significantly higher in Guizhou (11.4%), Sichuan (10.1%), Yunnan (9.3%), and Guangxi (6.9%) than that other province. We found that ethnicity and provincial background are significantly associated with HEV infection in this cohort. Conclusion: This study provides comprehensive information on HEV prevalence in multi-ethnic populations in China. However, our study only focused on a youth population from different provinces of China. Future studies are recommended to investigate HEV prevalence in other age groups of the ethnic populations.

AB - Background: This cohort study was designed to investigate the prevalence of and potential risk factors of HEV infection in a large multi-ethnic youth cohort in China. Methods: Blood samples were collected from participants (n = 6269) and serum was isolated. All serum samples were tested for anti-HEV IgG, anti-HEV IgM antibodies using commercial enzyme immunoassay kits (Wantai Biological Pharmacy Enterprise, Beijing, China). Results: The overall rate of anti-HEV IgG and anti-HEV IgM prevalence was 4.78% and 0.14%, 0.03% were positive for both anti-HEV IgG and anti-HEV IgM antibodies. Anti-HEV IgG positivity is significantly higher in females (5.27%) compared to males (4.14%) (P = 0.028). Anti-HEV IgG prevalence is significantly (P = 0.0001) higher in Dong (17.57%), Miao (12.23%), Yi (11.04%), Gelao (9.76%), and Bai (10.00%) compared to other ethnic groups. It is significantly higher in Guizhou (11.4%), Sichuan (10.1%), Yunnan (9.3%), and Guangxi (6.9%) than that other province. We found that ethnicity and provincial background are significantly associated with HEV infection in this cohort. Conclusion: This study provides comprehensive information on HEV prevalence in multi-ethnic populations in China. However, our study only focused on a youth population from different provinces of China. Future studies are recommended to investigate HEV prevalence in other age groups of the ethnic populations.

UR - http://www.scopus.com/inward/record.url?scp=85098789794&partnerID=8YFLogxK

U2 - 10.1186/s12985-020-01470-3

DO - 10.1186/s12985-020-01470-3

M3 - Article

C2 - 33407606

AN - SCOPUS:85098789794

SN - 1743-422X

VL - 18

JO - Virology Journal

JF - Virology Journal

IS - 1

M1 - 3

ER -

HEV prevalence and potential risk factors in a large multi-ethnic youth cohort in China

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this