High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus

Marcus Z.W. Tong; Katina D. Hulme; Soi Cheng Law; Ellesandra Noye; Emily S. Dorey; Keng Yih Chew; Louise C. Rowntree; Carolien E. van de Sandt; Katherine Kedzierska; Marco Goeijenbier; Katharina Ronacher; Fawaz Alzaid; Jean Baptiste Julla; Jean Pierre Riveline; Katie E. Lineburg; Corey Smith; Emma J. Grant; Stephanie Gras; Linda A. Gallo; Helen L. Barrett; Kirsty R. Short

doi:10.1016/j.isci.2024.111166

High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus

Marcus Z.W. Tong, Katina D. Hulme, Soi Cheng Law, Ellesandra Noye, Emily S. Dorey, Keng Yih Chew, Louise C. Rowntree, Carolien E. van de Sandt, Katherine Kedzierska, Marco Goeijenbier, Katharina Ronacher, Fawaz Alzaid, Jean Baptiste Julla, Jean Pierre Riveline, Katie E. Lineburg, Corey Smith, Emma J. Grant, Stephanie Gras, Linda A. Gallo, Helen L. BarrettKirsty R. Short^*

^*Corresponding author for this work

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Abstract

Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8⁺CD107a⁻IFNγ⁻MIP1β⁻TNF⁺ T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.

Original language	English
Article number	111166
Journal	iScience
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/j.isci.2024.111166
Publication status	Published - 15 Nov 2024

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© 2024 The Author(s)

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10.1016/j.isci.2024.111166

High glycemic variability is associated with a reduced T cell cytokine response to influenza A virusFinal published version, 2.22 MBLicence: CC BY-NC-ND

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Tong, M. Z. W., Hulme, K. D., Law, S. C., Noye, E., Dorey, E. S., Chew, K. Y., Rowntree, L. C., van de Sandt, C. E., Kedzierska, K., Goeijenbier, M., Ronacher, K., Alzaid, F., Julla, J. B., Riveline, J. P., Lineburg, K. E., Smith, C., Grant, E. J., Gras, S., Gallo, L. A., ... Short, K. R. (2024). High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus. iScience, 27(11), Article 111166. https://doi.org/10.1016/j.isci.2024.111166

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title = "High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus",

abstract = "Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8+CD107a−IFNγ−MIP1β−TNF+ T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.",

author = "Tong, {Marcus Z.W.} and Hulme, {Katina D.} and Law, {Soi Cheng} and Ellesandra Noye and Dorey, {Emily S.} and Chew, {Keng Yih} and Rowntree, {Louise C.} and {van de Sandt}, {Carolien E.} and Katherine Kedzierska and Marco Goeijenbier and Katharina Ronacher and Fawaz Alzaid and Julla, {Jean Baptiste} and Riveline, {Jean Pierre} and Lineburg, {Katie E.} and Corey Smith and Grant, {Emma J.} and Stephanie Gras and Gallo, {Linda A.} and Barrett, {Helen L.} and Short, {Kirsty R.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = nov,

day = "15",

doi = "10.1016/j.isci.2024.111166",

language = "English",

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Tong, MZW, Hulme, KD, Law, SC, Noye, E, Dorey, ES, Chew, KY, Rowntree, LC, van de Sandt, CE, Kedzierska, K, Goeijenbier, M, Ronacher, K, Alzaid, F, Julla, JB, Riveline, JP, Lineburg, KE, Smith, C, Grant, EJ, Gras, S, Gallo, LA, Barrett, HL & Short, KR 2024, 'High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus', iScience, vol. 27, no. 11, 111166. https://doi.org/10.1016/j.isci.2024.111166

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T1 - High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus

AU - Tong, Marcus Z.W.

AU - Hulme, Katina D.

AU - Law, Soi Cheng

AU - Noye, Ellesandra

AU - Dorey, Emily S.

AU - Chew, Keng Yih

AU - Rowntree, Louise C.

AU - van de Sandt, Carolien E.

AU - Kedzierska, Katherine

AU - Goeijenbier, Marco

AU - Ronacher, Katharina

AU - Alzaid, Fawaz

AU - Julla, Jean Baptiste

AU - Riveline, Jean Pierre

AU - Lineburg, Katie E.

AU - Smith, Corey

AU - Grant, Emma J.

AU - Gras, Stephanie

AU - Gallo, Linda A.

AU - Barrett, Helen L.

AU - Short, Kirsty R.

PY - 2024/11/15

Y1 - 2024/11/15

N2 - Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8+CD107a−IFNγ−MIP1β−TNF+ T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.

AB - Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8+CD107a−IFNγ−MIP1β−TNF+ T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.

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JO - iScience

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High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus

Abstract

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