High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring

Dineke Smedts, JH (Jeanne) de Vries, M Rakhshandehroo, Mark Wildhagen, AC Verkleij-Hagoort, Eric Steegers, Régine Steegers - Theunissen

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To study associations between maternal dietary and supplement intake of antioxidants vitamin E, retinol and congenital heart defects (CHDs). Case-control study. Erasmus MC, University Medical Center Rotterdam, the Netherlands. Participants were 276 case mothers of a child with CHD and 324 control mothers with their children. Food frequency questionnaires covering the intake of the previous 4 weeks were filled out at 16 months after the index pregnancy. Data were compared between cases and controls using the Mann-Whitney U test. Risk estimates for the association between CHD and dietary intake of vitamin E and retinol were estimated in a multivariable logistic regression model. Medians (5-95th percentile) and odds ratios with 95% CI. Dietary vitamin E intake was higher in case mothers than in controls, 13.3 (8.1-20.4) and 12.6 (8.5-19.8) mg/day (P = 0.05). CHD risk increased with rising dietary vitamin E intakes (P-trend = 0.01). Periconception use of vitamin E supplements in addition to a high dietary vitamin E intake above 14.9 mg/day up to nine-fold increased CHD risk. Retinol intakes were not significantly different between the groups and not associated with CHD risk. High maternal vitamin E by diet and supplements is associated with an increased risk of CHD offspring.
Original languageUndefined/Unknown
Pages (from-to)416-423
Number of pages8
JournalBjog-An International Journal of Obstetrics and Gynaecology
Issue number3
Publication statusPublished - 2009

Research programs

  • EMC MGC-02-52-01-A
  • EMC MGC-02-96-01
  • EMC MM-03-49-01
  • EMC NIHES-01-64-02

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