High Preoperative Plasma Neopterin Predicts Delirium After Cardiac Surgery in Older Adults

R.J. Osse, Durk Fekkes, Joke Tulen, André Wierdsma, Ad Bogers, RC van der Mast, Michiel Hengeveld

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OBJECTIVES: To examine the association between plasma levels of pterins and amino acids and postoperative delirium. DESIGN: Prospective cohort study. SETTING: Cardiothoracic service in an university hospital in Rotterdam, the Netherlands. PARTICIPANTS: One hundred twenty-five individuals aged 70 and older undergoing elective cardiac surgery. MEASUREMENTS: Plasma pterins and amino acids were measured pre- and postoperatively. Using multiple logistic regression analyses, the associations between pterins and amino acid levels and postoperative delirium were examined in relation to age, sex, comorbidity, cognitive functioning (Mini-Mental State Examination (MMSE) score), and cardiac risk factors. RESULTS: Delirium incidence in the main study group was 31.3%. The preoperative measures associated with delirium were neopterin (odds ratio (OR) = 1.05, P = .009); MMSE score less than 28 (OR = 4.39, P = .001); European System for Cardiac Operative Risk Evaluation score greater than 6 (OR = 2.84, P = .03); and combined coronary artery bypass graft (CABG) and aortic, mitral, or tricuspid valve surgery (OR = 4.32, P = .01). Postoperative measures associated with delirium were neopterin (OR = 3.84 CONCLUSION: Preoperatively high neopterin levels predicted delirium after cardiac surgery in older adults, in addition to the well-known risk factors of poor cognitive function, high cardio-surgical risk, and combined CABG and valve surgery. Postoperative neopterin and HVA levels were also found to be associated with delirium, together with preoperative cognitive functioning. Plasma neopterin may be a candidate biomarker for delirium after cardiac surgery in these older adults. J Am Geriatr Soc
Original languageUndefined/Unknown
Pages (from-to)661-668
Number of pages8
JournalJournal of American Geriatrics Society
Issue number4
Publication statusPublished - 2012

Research programs

  • EMC COEUR-09
  • EMC ONWAR-01-58-02
  • EMC ONWAR-01-94-01
  • EMC OR-01-58-01

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