High-speed intracoronary optical frequency domain imaging: implications for three-dimensional reconstruction and quantitative analysis

Aim: To assess the reproducibility of quantitative analysis of optical frequency domain imaging (OFDI) acquired at different pullback speeds (20, 30, 40 mm/sec), as well as the impact of cardiac motion artefact on three-dimensional (3D) reconstructions. Methods and results: A total of 36 OFDI pullbacks were obtained pre- and post-stent implantation at the pullback speeds of 20, 30 and 40 mm/sec in non-diseased swine coronary arteries. The amount of x-ray contrast needed for blood clearance during OFDI imaging was recorded. Three-dimensional images of stented segments were rendered and artefacts on 3D images were assessed. Lumen areas (LA) were measured on each individual frame in pre- and post-stent pullbacks. The volume of contrast used with a Conclusions: Quantitative analysis of OFDI obtained at different pullback speeds in non-stented coronary arteries could potentially vary in LA measurement. OFDI with high-speed pullback allows quantitative analysis of stented vessels while reducing the amount of contrast and cardiac motion artefacts.