High-volume and High-intensity Functional Training in Patients with Multiple Sclerosis: A Pilot Study on Feasibility and Functional Capacity

Tom C A Derikx; Ingrid M H Brands; Arne T Goedhart; Wouter H Hoens; Majanka H Heijenbrok-Kal; Rita H J G VAN DEN Berg-Emons

doi:10.2340/jrmcc.v5.2047

High-volume and High-intensity Functional Training in Patients with Multiple Sclerosis: A Pilot Study on Feasibility and Functional Capacity

Tom C A Derikx^*, Ingrid M H Brands, Arne T Goedhart, Wouter H Hoens, Majanka H Heijenbrok-Kal, Rita H J G VAN DEN Berg-Emons

^*Corresponding author for this work

Rehabilitation Medicine

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: To evaluate the feasibility of a high-volume and high-intensity functional training programme in patients with multiple sclerosis (MS), and to explore whether functional capacity improves. A further objective was to explore changes in muscle strength and aerobic capacity.

METHODS: This pilot study comprised a 12-week intervention, with an 8-week follow-up period. The intervention consisted of 3 weekly 3-h training sessions, comprising functional resistance-, endurance-, and skills training. Feasibility (questionnaire), functional capacity (Timed Up and Go Test, 10-Meter Walk Test, and 6-Minute Walk Test), aerobic capacity (cardiopulmonary exercise test) and muscle strength (1 repetition maximum (RM) leg press) were evaluated.

RESULTS: Seven patients completed the study. Patients attended a mean of 93% of the training sessions. One adverse event was reported, which was not related to the training programme. Patients scored positive or very positive on 86% of the feasibility aspects and scored an overall grade of 8.9 on a scale of 1-10 regarding satisfaction with the training programme. Functional capacity, aerobic capacity, and muscle strength seemed to be improved after the training programme, but the improvements were not always sustained.

CONCLUSION: This new high-volume and high-intensity functional training programme appeared to be feasible in patients with MS, and may improve their functional capacity, aerobic capacity and muscle strength. A large-scale controlled trial over a longer period of time is required to evaluate the added value of the training programme.

Original language	English
Article number	2047
Number of pages	9
Journal	Journal of rehabilitation medicine. Clinical communications
Volume	5
DOIs	https://doi.org/10.2340/jrmcc.v5.2047
Publication status	Published - 7 Apr 2022

Bibliographical note

Funding support:
The authors disclosed receipt of the following financial
support for the research, authorship, and/or publication
of this article: this work was supported by the CZ Fonds
[201700286].

© Published by Medical Journals Sweden, on behalf of the Foundation for Rehabilitation Information.

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Derikx, T. C. A., Brands, I. M. H., Goedhart, A. T., Hoens, W. H., Heijenbrok-Kal, M. H., & VAN DEN Berg-Emons, R. H. J. G. (2022). High-volume and High-intensity Functional Training in Patients with Multiple Sclerosis: A Pilot Study on Feasibility and Functional Capacity. Journal of rehabilitation medicine. Clinical communications, 5, Article 2047. https://doi.org/10.2340/jrmcc.v5.2047

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abstract = "OBJECTIVE: To evaluate the feasibility of a high-volume and high-intensity functional training programme in patients with multiple sclerosis (MS), and to explore whether functional capacity improves. A further objective was to explore changes in muscle strength and aerobic capacity.METHODS: This pilot study comprised a 12-week intervention, with an 8-week follow-up period. The intervention consisted of 3 weekly 3-h training sessions, comprising functional resistance-, endurance-, and skills training. Feasibility (questionnaire), functional capacity (Timed Up and Go Test, 10-Meter Walk Test, and 6-Minute Walk Test), aerobic capacity (cardiopulmonary exercise test) and muscle strength (1 repetition maximum (RM) leg press) were evaluated.RESULTS: Seven patients completed the study. Patients attended a mean of 93% of the training sessions. One adverse event was reported, which was not related to the training programme. Patients scored positive or very positive on 86% of the feasibility aspects and scored an overall grade of 8.9 on a scale of 1-10 regarding satisfaction with the training programme. Functional capacity, aerobic capacity, and muscle strength seemed to be improved after the training programme, but the improvements were not always sustained.CONCLUSION: This new high-volume and high-intensity functional training programme appeared to be feasible in patients with MS, and may improve their functional capacity, aerobic capacity and muscle strength. A large-scale controlled trial over a longer period of time is required to evaluate the added value of the training programme.",

author = "Derikx, {Tom C A} and Brands, {Ingrid M H} and Goedhart, {Arne T} and Hoens, {Wouter H} and Heijenbrok-Kal, {Majanka H} and {VAN DEN Berg-Emons}, {Rita H J G}",

note = "Funding support: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this work was supported by the CZ Fonds [201700286]. {\textcopyright} Published by Medical Journals Sweden, on behalf of the Foundation for Rehabilitation Information.",

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High-volume and High-intensity Functional Training in Patients with Multiple Sclerosis: A Pilot Study on Feasibility and Functional Capacity. / Derikx, Tom C A; Brands, Ingrid M H; Goedhart, Arne T et al.
In: Journal of rehabilitation medicine. Clinical communications, Vol. 5, 2047, 07.04.2022.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - High-volume and High-intensity Functional Training in Patients with Multiple Sclerosis

T2 - A Pilot Study on Feasibility and Functional Capacity

AU - Derikx, Tom C A

AU - Brands, Ingrid M H

AU - Goedhart, Arne T

AU - Hoens, Wouter H

AU - Heijenbrok-Kal, Majanka H

AU - VAN DEN Berg-Emons, Rita H J G

N1 - Funding support: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this work was supported by the CZ Fonds [201700286]. © Published by Medical Journals Sweden, on behalf of the Foundation for Rehabilitation Information.

PY - 2022/4/7

Y1 - 2022/4/7

N2 - OBJECTIVE: To evaluate the feasibility of a high-volume and high-intensity functional training programme in patients with multiple sclerosis (MS), and to explore whether functional capacity improves. A further objective was to explore changes in muscle strength and aerobic capacity.METHODS: This pilot study comprised a 12-week intervention, with an 8-week follow-up period. The intervention consisted of 3 weekly 3-h training sessions, comprising functional resistance-, endurance-, and skills training. Feasibility (questionnaire), functional capacity (Timed Up and Go Test, 10-Meter Walk Test, and 6-Minute Walk Test), aerobic capacity (cardiopulmonary exercise test) and muscle strength (1 repetition maximum (RM) leg press) were evaluated.RESULTS: Seven patients completed the study. Patients attended a mean of 93% of the training sessions. One adverse event was reported, which was not related to the training programme. Patients scored positive or very positive on 86% of the feasibility aspects and scored an overall grade of 8.9 on a scale of 1-10 regarding satisfaction with the training programme. Functional capacity, aerobic capacity, and muscle strength seemed to be improved after the training programme, but the improvements were not always sustained.CONCLUSION: This new high-volume and high-intensity functional training programme appeared to be feasible in patients with MS, and may improve their functional capacity, aerobic capacity and muscle strength. A large-scale controlled trial over a longer period of time is required to evaluate the added value of the training programme.

AB - OBJECTIVE: To evaluate the feasibility of a high-volume and high-intensity functional training programme in patients with multiple sclerosis (MS), and to explore whether functional capacity improves. A further objective was to explore changes in muscle strength and aerobic capacity.METHODS: This pilot study comprised a 12-week intervention, with an 8-week follow-up period. The intervention consisted of 3 weekly 3-h training sessions, comprising functional resistance-, endurance-, and skills training. Feasibility (questionnaire), functional capacity (Timed Up and Go Test, 10-Meter Walk Test, and 6-Minute Walk Test), aerobic capacity (cardiopulmonary exercise test) and muscle strength (1 repetition maximum (RM) leg press) were evaluated.RESULTS: Seven patients completed the study. Patients attended a mean of 93% of the training sessions. One adverse event was reported, which was not related to the training programme. Patients scored positive or very positive on 86% of the feasibility aspects and scored an overall grade of 8.9 on a scale of 1-10 regarding satisfaction with the training programme. Functional capacity, aerobic capacity, and muscle strength seemed to be improved after the training programme, but the improvements were not always sustained.CONCLUSION: This new high-volume and high-intensity functional training programme appeared to be feasible in patients with MS, and may improve their functional capacity, aerobic capacity and muscle strength. A large-scale controlled trial over a longer period of time is required to evaluate the added value of the training programme.

U2 - 10.2340/jrmcc.v5.2047

DO - 10.2340/jrmcc.v5.2047

M3 - Article

C2 - 35528146

SN - 2003-0711

VL - 5

JO - Journal of rehabilitation medicine. Clinical communications

JF - Journal of rehabilitation medicine. Clinical communications

M1 - 2047

ER -

High-volume and High-intensity Functional Training in Patients with Multiple Sclerosis: A Pilot Study on Feasibility and Functional Capacity

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