Higher mean cerebral oxygen saturation shortly after extracorporeal cardiopulmonary resuscitation in patients who regain consciousness

Loes Mandigers*, Corstiaan A. den Uil, Mirko Belliato, Hannelore Raemen, Eleonora Rossi, Joost van Rosmalen, Wim J.R. Rietdijk, Joo Ree Melis, Diederik Gommers, Robert J. van Thiel, Dinis dos Reis Miranda*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
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Abstract

Introduction: In cardiac arrest, cerebral ischemia and reperfusion injury mainly determine the neurological outcome. The aim of this study was to investigate the relation between the course of cerebral oxygenation and regain of consciousness in patients treated with extracorporeal cardiopulmonary resuscitation (ECPR). We hypothesized that rapid cerebral oxygenation increase causes unfavorable outcomes. Methods: This prospective observational study was conducted in three European hospitals. We included adult ECPR patients between October 2018 and March 2020, in whom cerebral regional oxygen saturation (rSO2) measurements were started minutes before ECPR initiation until 3 h after. The primary outcome was regain of consciousness, defined as following commands, analyzed using binary logistic regression. Results: The sample consisted of 26 ECPR patients (23% women, Agemean 46 years). We found no significant differences in rSO2 values at baseline (49.1% versus 49.3% for regain versus no regain of consciousness). Mean cerebral rSO2 values in the first 30 min after ECPR initiation were higher in patients who regained consciousness (38%) than in patients who did not regain consciousness (62%, odds ratio 1.23, 95% confidence interval 1.01–1.50). Conclusion: Higher mean cerebral rSO2 values in the first 30 min after initiation of ECPR were found in patients who regained consciousness.

Original languageEnglish
Pages (from-to)1479-1489
Number of pages11
JournalArtificial Organs
Volume47
Issue number9
Early online date12 Apr 2023
DOIs
Publication statusPublished - Sept 2023

Bibliographical note

Funding Information:
We would like to thank Dr. Enrico Contri (AAT 118 Pavia, AREU Lombardia, Italy) and Nonin, Plymouth Minnesota, USA for their contributions.

Publisher Copyright:
© 2023 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.

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