Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

Bas B. Oude Munnink*, Roel H.T. Nijhuis, Nathalie Worp, Marjan Boter, Babette Weller, Babs E. Verstrepen, Corine GeurtsvanKessel, Maarten L. Corsten, Anne Russcher, Marion Koopmans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
9 Downloads (Pure)


We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.

Original languageEnglish
Pages (from-to)1920-1923
Number of pages4
JournalEmerging Infectious Diseases
Issue number9
Publication statusPublished - Sept 2022

Bibliographical note

Funding Information:
This work is supported by European Union's Horizon 2020 research and innovation program under grant nos. 874735 (VEO) and 101003589 (RECoVER), as well as by ZonMW under grant no. 10150062010005.

Funding Information:
This research was supported in part by a gift to the Keck

Publisher Copyright:
© 2022 Centers for Disease Control and Prevention (CDC). All rights reserved.


Dive into the research topics of 'Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person'. Together they form a unique fingerprint.

Cite this