Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

Bas B. Oude Munnink; Roel H.T. Nijhuis; Nathalie Worp; Marjan Boter; Babette Weller; Babs E. Verstrepen; Corine GeurtsvanKessel; Maarten L. Corsten; Anne Russcher; Marion Koopmans

doi:10.3201/EID2809.220875

Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

Bas B. Oude Munnink^*, Roel H.T. Nijhuis, Nathalie Worp, Marjan Boter, Babette Weller, Babs E. Verstrepen, Corine GeurtsvanKessel, Maarten L. Corsten, Anne Russcher, Marion Koopmans

^*Corresponding author for this work

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Abstract

We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.

Original language	English
Pages (from-to)	1920-1923
Number of pages	4
Journal	Emerging Infectious Diseases
Volume	28
Issue number	9
DOIs	https://doi.org/10.3201/EID2809.220875
Publication status	Published - Sep 2022

Bibliographical note

Funding Information:
This work is supported by European Union's Horizon 2020 research and innovation program under grant nos. 874735 (VEO) and 101003589 (RECoVER), as well as by ZonMW under grant no. 10150062010005.

Funding Information:
This research was supported in part by a gift to the Keck

Publisher Copyright:
© 2022 Centers for Disease Control and Prevention (CDC). All rights reserved.

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title = "Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person",

abstract = "We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.",

author = "{Oude Munnink}, {Bas B.} and Nijhuis, {Roel H.T.} and Nathalie Worp and Marjan Boter and Babette Weller and Verstrepen, {Babs E.} and Corine GeurtsvanKessel and Corsten, {Maarten L.} and Anne Russcher and Marion Koopmans",

note = "Funding Information: This work is supported by European Union's Horizon 2020 research and innovation program under grant nos. 874735 (VEO) and 101003589 (RECoVER), as well as by ZonMW under grant no. 10150062010005. Funding Information: This research was supported in part by a gift to the Keck Publisher Copyright: {\textcopyright} 2022 Centers for Disease Control and Prevention (CDC). All rights reserved.",

year = "2022",

month = sep,

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AU - Oude Munnink, Bas B.

AU - Nijhuis, Roel H.T.

AU - Worp, Nathalie

AU - Boter, Marjan

AU - Weller, Babette

AU - Verstrepen, Babs E.

AU - GeurtsvanKessel, Corine

AU - Corsten, Maarten L.

AU - Russcher, Anne

AU - Koopmans, Marion

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AB - We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.

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Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

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