Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

Emily Latacz; Diederik Höppener; Ali Bohlok; Sophia Leduc; Sébastien Tabariès; Carlos Fernández Moro; Claire Lugassy; Hanna Nyström; Béla Bozóky; Giuseppe Floris; Natalie Geyer; Pnina Brodt; Laura Llado; Laura Van Mileghem; Maxim De Schepper; Ali W. Majeed; Anthoula Lazaris; Piet Dirix; Qianni Zhang; Stéphanie K. Petrillo; Sophie Vankerckhove; Ines Joye; Yannick Meyer; Alexander Gregorieff; Nuria Ruiz Roig; Fernando Vidal-Vanaclocha; Larsimont Denis; Rui Caetano Oliveira; Peter Metrakos; Dirk J. Grünhagen; Iris D. Nagtegaal; David G. Mollevi; William R. Jarnagin; Michael I. D’Angelica; Andrew R. Reynolds; Michail Doukas; Christine Desmedt; Luc Dirix; Vincent Donckier; Peter M. Siegel; Raymond Barnhill; Marco Gerling; Cornelis Verhoef; Peter B. Vermeulen

doi:10.1038/s41416-022-01859-7

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

Emily Latacz, Diederik Höppener, Ali Bohlok, Sophia Leduc, Sébastien Tabariès, Carlos Fernández Moro, Claire Lugassy, Hanna Nyström, Béla Bozóky, Giuseppe Floris, Natalie Geyer, Pnina Brodt, Laura Llado, Laura Van Mileghem, Maxim De Schepper, Ali W. Majeed, Anthoula Lazaris, Piet Dirix, Qianni Zhang, Stéphanie K. PetrilloSophie Vankerckhove, Ines Joye, Yannick Meyer, Alexander Gregorieff, Nuria Ruiz Roig, Fernando Vidal-Vanaclocha, Larsimont Denis, Rui Caetano Oliveira, Peter Metrakos, Dirk J. Grünhagen, Iris D. Nagtegaal, David G. Mollevi, William R. Jarnagin, Michael I. D’Angelica, Andrew R. Reynolds, Michail Doukas, Christine Desmedt, Luc Dirix, Vincent Donckier, Peter M. Siegel, Raymond Barnhill, Marco Gerling, Cornelis Verhoef, Peter B. Vermeulen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

42 Citations (Scopus)

Abstract

The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then, numerous studies have applied these guidelines, have further substantiated the potential clinical value of the HGPs in patients with liver metastases from various tumour types and are starting to shed light on the biology of the distinct HGPs. In the present guidelines, we give an overview of these studies, discuss novel strategies for predicting the HGPs of liver metastases, such as deep-learning algorithms for whole-slide histopathology images and medical imaging, and highlight liver metastasis animal models that exhibit features of the different HGPs. Based on a pooled analysis of large cohorts of patients with liver-metastatic colorectal cancer, we propose a new cut-off to categorise patients according to the HGPs. An up-to-date standard method for HGP assessment within liver metastases is also presented with the aim of incorporating HGPs into the decision-making processes surrounding the treatment of patients with liver-metastatic cancer. Finally, we propose hypotheses on the cellular and molecular mechanisms that drive the biology of the different HGPs, opening some exciting preclinical and clinical research perspectives.

Original language	English
Pages (from-to)	988-1013
Number of pages	26
Journal	British Journal of Cancer
Volume	127
Issue number	6
DOIs	https://doi.org/10.1038/s41416-022-01859-7 https://doi.org/10.1038/s41416-022-01859-7
Publication status	Published - 5 Oct 2022

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470557

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Latacz, E., Höppener, D., Bohlok, A., Leduc, S., Tabariès, S., Fernández Moro, C., Lugassy, C., Nyström, H., Bozóky, B., Floris, G., Geyer, N., Brodt, P., Llado, L., Van Mileghem, L., De Schepper, M., Majeed, A. W., Lazaris, A., Dirix, P., Zhang, Q., ... Vermeulen, P. B. (2022). Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights. British Journal of Cancer, 127(6), 988-1013. https://doi.org/10.1038/s41416-022-01859-7, https://doi.org/10.1038/s41416-022-01859-7

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title = "Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights",

abstract = "The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then, numerous studies have applied these guidelines, have further substantiated the potential clinical value of the HGPs in patients with liver metastases from various tumour types and are starting to shed light on the biology of the distinct HGPs. In the present guidelines, we give an overview of these studies, discuss novel strategies for predicting the HGPs of liver metastases, such as deep-learning algorithms for whole-slide histopathology images and medical imaging, and highlight liver metastasis animal models that exhibit features of the different HGPs. Based on a pooled analysis of large cohorts of patients with liver-metastatic colorectal cancer, we propose a new cut-off to categorise patients according to the HGPs. An up-to-date standard method for HGP assessment within liver metastases is also presented with the aim of incorporating HGPs into the decision-making processes surrounding the treatment of patients with liver-metastatic cancer. Finally, we propose hypotheses on the cellular and molecular mechanisms that drive the biology of the different HGPs, opening some exciting preclinical and clinical research perspectives.",

author = "Emily Latacz and Diederik H{\"o}ppener and Ali Bohlok and Sophia Leduc and S{\'e}bastien Tabari{\`e}s and {Fern{\'a}ndez Moro}, Carlos and Claire Lugassy and Hanna Nystr{\"o}m and B{\'e}la Boz{\'o}ky and Giuseppe Floris and Natalie Geyer and Pnina Brodt and Laura Llado and {Van Mileghem}, Laura and {De Schepper}, Maxim and Majeed, {Ali W.} and Anthoula Lazaris and Piet Dirix and Qianni Zhang and Petrillo, {St{\'e}phanie K.} and Sophie Vankerckhove and Ines Joye and Yannick Meyer and Alexander Gregorieff and Roig, {Nuria Ruiz} and Fernando Vidal-Vanaclocha and Larsimont Denis and Oliveira, {Rui Caetano} and Peter Metrakos and Gr{\"u}nhagen, {Dirk J.} and Nagtegaal, {Iris D.} and Mollevi, {David G.} and Jarnagin, {William R.} and D{\textquoteright}Angelica, {Michael I.} and Reynolds, {Andrew R.} and Michail Doukas and Christine Desmedt and Luc Dirix and Vincent Donckier and Siegel, {Peter M.} and Raymond Barnhill and Marco Gerling and Cornelis Verhoef and Vermeulen, {Peter B.}",

note = "{\textcopyright} 2022. The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2022",

month = oct,

day = "5",

doi = "10.1038/s41416-022-01859-7",

language = "English",

volume = "127",

pages = "988--1013",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "6",

}

Latacz, E, Höppener, D, Bohlok, A, Leduc, S, Tabariès, S, Fernández Moro, C, Lugassy, C, Nyström, H, Bozóky, B, Floris, G, Geyer, N, Brodt, P, Llado, L, Van Mileghem, L, De Schepper, M, Majeed, AW, Lazaris, A, Dirix, P, Zhang, Q, Petrillo, SK, Vankerckhove, S, Joye, I, Meyer, Y, Gregorieff, A, Roig, NR, Vidal-Vanaclocha, F, Denis, L, Oliveira, RC, Metrakos, P, Grünhagen, DJ, Nagtegaal, ID, Mollevi, DG, Jarnagin, WR, D’Angelica, MI, Reynolds, AR, Doukas, M, Desmedt, C, Dirix, L, Donckier, V, Siegel, PM, Barnhill, R, Gerling, M, Verhoef, C & Vermeulen, PB 2022, 'Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights', British Journal of Cancer, vol. 127, no. 6, pp. 988-1013. https://doi.org/10.1038/s41416-022-01859-7, https://doi.org/10.1038/s41416-022-01859-7

TY - JOUR

T1 - Histopathological growth patterns of liver metastasis

T2 - updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

AU - Latacz, Emily

AU - Höppener, Diederik

AU - Bohlok, Ali

AU - Leduc, Sophia

AU - Tabariès, Sébastien

AU - Fernández Moro, Carlos

AU - Lugassy, Claire

AU - Nyström, Hanna

AU - Bozóky, Béla

AU - Floris, Giuseppe

AU - Geyer, Natalie

AU - Brodt, Pnina

AU - Llado, Laura

AU - Van Mileghem, Laura

AU - De Schepper, Maxim

AU - Majeed, Ali W.

AU - Lazaris, Anthoula

AU - Dirix, Piet

AU - Zhang, Qianni

AU - Petrillo, Stéphanie K.

AU - Vankerckhove, Sophie

AU - Joye, Ines

AU - Meyer, Yannick

AU - Gregorieff, Alexander

AU - Roig, Nuria Ruiz

AU - Vidal-Vanaclocha, Fernando

AU - Denis, Larsimont

AU - Oliveira, Rui Caetano

AU - Metrakos, Peter

AU - Grünhagen, Dirk J.

AU - Nagtegaal, Iris D.

AU - Mollevi, David G.

AU - Jarnagin, William R.

AU - D’Angelica, Michael I.

AU - Reynolds, Andrew R.

AU - Doukas, Michail

AU - Desmedt, Christine

AU - Dirix, Luc

AU - Donckier, Vincent

AU - Siegel, Peter M.

AU - Barnhill, Raymond

AU - Gerling, Marco

AU - Verhoef, Cornelis

AU - Vermeulen, Peter B.

PY - 2022/10/5

Y1 - 2022/10/5

N2 - The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then, numerous studies have applied these guidelines, have further substantiated the potential clinical value of the HGPs in patients with liver metastases from various tumour types and are starting to shed light on the biology of the distinct HGPs. In the present guidelines, we give an overview of these studies, discuss novel strategies for predicting the HGPs of liver metastases, such as deep-learning algorithms for whole-slide histopathology images and medical imaging, and highlight liver metastasis animal models that exhibit features of the different HGPs. Based on a pooled analysis of large cohorts of patients with liver-metastatic colorectal cancer, we propose a new cut-off to categorise patients according to the HGPs. An up-to-date standard method for HGP assessment within liver metastases is also presented with the aim of incorporating HGPs into the decision-making processes surrounding the treatment of patients with liver-metastatic cancer. Finally, we propose hypotheses on the cellular and molecular mechanisms that drive the biology of the different HGPs, opening some exciting preclinical and clinical research perspectives.

AB - The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then, numerous studies have applied these guidelines, have further substantiated the potential clinical value of the HGPs in patients with liver metastases from various tumour types and are starting to shed light on the biology of the distinct HGPs. In the present guidelines, we give an overview of these studies, discuss novel strategies for predicting the HGPs of liver metastases, such as deep-learning algorithms for whole-slide histopathology images and medical imaging, and highlight liver metastasis animal models that exhibit features of the different HGPs. Based on a pooled analysis of large cohorts of patients with liver-metastatic colorectal cancer, we propose a new cut-off to categorise patients according to the HGPs. An up-to-date standard method for HGP assessment within liver metastases is also presented with the aim of incorporating HGPs into the decision-making processes surrounding the treatment of patients with liver-metastatic cancer. Finally, we propose hypotheses on the cellular and molecular mechanisms that drive the biology of the different HGPs, opening some exciting preclinical and clinical research perspectives.

UR - http://www.scopus.com/inward/record.url?scp=85131305358&partnerID=8YFLogxK

U2 - 10.1038/s41416-022-01859-7

DO - 10.1038/s41416-022-01859-7

M3 - Review article

C2 - 35650276

AN - SCOPUS:85131305358

SN - 0007-0920

VL - 127

SP - 988

EP - 1013

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 6

ER -

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

Abstract

Bibliographical note

UN SDGs

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