HLA-DQ2(+) individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes

Marieke Graaf; Janet Beukelaar; GW Haasnoot; Wilfried Levering; V Rogemond; A Didelot; J Honnorat; Jan willem Gratama; Peter Sillevis Smitt

doi:10.1016/j.jneuroim.2010.05.035

HLA-DQ2(+) individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes

Marieke Graaf, Janet Beukelaar, GW Haasnoot, Wilfried Levering, V Rogemond, A Didelot, J Honnorat, Jan willem Gratama, Peter Sillevis Smitt

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

Background: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS). Objective: To identify genetic risk factors for Hu-PNS and investigate the role of T cells. Methods: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC). Results: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC. Conclusions: This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS. (C) 2010 Elsevier B.V. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	147-149
Number of pages	3
Journal	Journal of Neuroimmunology
Volume	226
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2010.05.035
Publication status	Published - 2010

Research programs

EMC MM-03-44-06
EMC MM-03-86-01

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jneuroim.2010.05.035

http://hdl.handle.net/1765/27732

Cite this

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title = "HLA-DQ2(+) individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes",

abstract = "Background: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS). Objective: To identify genetic risk factors for Hu-PNS and investigate the role of T cells. Methods: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC). Results: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC. Conclusions: This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS. (C) 2010 Elsevier B.V. All rights reserved.",

author = "Marieke Graaf and Janet Beukelaar and GW Haasnoot and Wilfried Levering and V Rogemond and A Didelot and J Honnorat and Gratama, \{Jan willem\} and \{Sillevis Smitt\}, Peter",

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doi = "10.1016/j.jneuroim.2010.05.035",

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TY - JOUR

T1 - HLA-DQ2(+) individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes

AU - Graaf, Marieke

AU - Beukelaar, Janet

AU - Haasnoot, GW

AU - Levering, Wilfried

AU - Rogemond, V

AU - Didelot, A

AU - Honnorat, J

AU - Gratama, Jan willem

AU - Sillevis Smitt, Peter

PY - 2010

Y1 - 2010

N2 - Background: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS). Objective: To identify genetic risk factors for Hu-PNS and investigate the role of T cells. Methods: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC). Results: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC. Conclusions: This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS. (C) 2010 Elsevier B.V. All rights reserved.

AB - Background: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS). Objective: To identify genetic risk factors for Hu-PNS and investigate the role of T cells. Methods: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC). Results: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC. Conclusions: This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS. (C) 2010 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.jneuroim.2010.05.035

DO - 10.1016/j.jneuroim.2010.05.035

M3 - Article

C2 - 20547426

SN - 0165-5728

VL - 226

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

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