TY - JOUR
T1 - Hodgkin lymphoma
T2 - hypodense lesions in mediastinal masses
AU - Damek, Adrian
AU - Kurch, Lars
AU - Franke, Friedrich Christian
AU - Attarbaschi, Andishe
AU - Beishuizen, Auke
AU - Cepelova, Michaela
AU - Ceppi, Francesco
AU - Daw, Stephen
AU - Dieckmann, Karin
AU - Fernández-Teijeiro, Ana
AU - Feuchtinger, Tobias
AU - Flerlage, Jamie E.
AU - Fosså, Alexander
AU - Georgi, Thomas W.
AU - Hasenclever, Dirk
AU - Hraskova, Andrea
AU - Karlen, Jonas
AU - Klekawka, Tomasz
AU - Kluge, Regine
AU - Körholz, Dieter
AU - Landman-Parker, Judith
AU - Leblanc, Thierry
AU - Mauz-Körholz, Christine
AU - Metzler, Markus
AU - Pears, Jane
AU - Steglich, Jonas
AU - Uyttebroeck, Anne
AU - Vordermark, Dirk
AU - Wallace, William Hamish
AU - Wohlgemuth, Walter Alexander
AU - Stoevesandt, Dietrich
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/6/25
Y1 - 2024/6/25
N2 - Hypodense volumes (HDV) in mediastinal masses can be visualized in a computed tomography scan in Hodgkin lymphoma. We analyzed staging CT scans of 1178 patients with mediastinal involvement from the EuroNet-PHL-C1 trial and explored correlations of HDV with patient characteristics, mediastinal tumor volume and progression-free survival. HDV occurred in 350 of 1178 patients (29.7%), typically in larger mediastinal volumes. There were different patterns in appearance with single lesions found in 243 patients (69.4%), multiple lesions in 107 patients (30.6%). Well delineated lesions were found in 248 cases (70.1%), diffuse lesions were seen in 102 cases (29.1%). Clinically, B symptoms occurred more often in patients with HDV (47.7% compared to 35.0% without HDV (p = 0.039)) and patients with HDV tended to be in higher risk groups. Inadequate overall early-18F-FDG-PET-response was strongly correlated with the occurrence of hypodense lesions (p < 0.001). Patients with total HDV > 40 ml (n = 80) had a 5 year PFS of 79.6% compared to 89.7% (p = 0.01) in patients with HDV < 40 ml or no HDV. This difference in PFS is not caused by treatment group alone. HDV is a common phenomenon in HL with mediastinal involvement.
AB - Hypodense volumes (HDV) in mediastinal masses can be visualized in a computed tomography scan in Hodgkin lymphoma. We analyzed staging CT scans of 1178 patients with mediastinal involvement from the EuroNet-PHL-C1 trial and explored correlations of HDV with patient characteristics, mediastinal tumor volume and progression-free survival. HDV occurred in 350 of 1178 patients (29.7%), typically in larger mediastinal volumes. There were different patterns in appearance with single lesions found in 243 patients (69.4%), multiple lesions in 107 patients (30.6%). Well delineated lesions were found in 248 cases (70.1%), diffuse lesions were seen in 102 cases (29.1%). Clinically, B symptoms occurred more often in patients with HDV (47.7% compared to 35.0% without HDV (p = 0.039)) and patients with HDV tended to be in higher risk groups. Inadequate overall early-18F-FDG-PET-response was strongly correlated with the occurrence of hypodense lesions (p < 0.001). Patients with total HDV > 40 ml (n = 80) had a 5 year PFS of 79.6% compared to 89.7% (p = 0.01) in patients with HDV < 40 ml or no HDV. This difference in PFS is not caused by treatment group alone. HDV is a common phenomenon in HL with mediastinal involvement.
UR - https://www.scopus.com/pages/publications/85196917755
U2 - 10.1038/s41598-024-64253-8
DO - 10.1038/s41598-024-64253-8
M3 - Article
C2 - 38918503
AN - SCOPUS:85196917755
SN - 2045-2322
VL - 14
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 14591
ER -