TY - JOUR
T1 - How Do Patients With Type 2 Diabetes Mellitus Value the Importance of Outcomes?
T2 - An Overview of Reviews
AU - Niño-de-Guzmán, Ena
AU - Bracchiglione, Javier
AU - Vásquez-Mejía, Adrián
AU - de Graaf, Gimon
AU - Rocha Calderón, Claudio
AU - Alonso-Coello, Pablo
N1 - Publisher Copyright:
© 2023 International Society for Pharmacoeconomics and Outcomes Research, Inc.
PY - 2023/12
Y1 - 2023/12
N2 - Objectives: We aimed to assess how patients value the importance of type 2 diabetes mellitus (T2DM) related outcomes. Methods: Overview of systematic reviews (SRs) reporting patients’ utilities or disutilities for T2DM outcomes. We searched 3 databases from inception until June 2021. Study selection and data extraction were conducted in pairs. We evaluated the quality of SRs with the Joanna Briggs Institute Checklist, and the overlap with the corrected covered area. We estimated descriptive statistics, and, when possible, conducted metanalysis. Results: We identified 11 SRs, including 119 studies and 70 outcomes. Most reviews were high-quality SRs. The outcomes with the lowest utilities were hypoglycemia with very severe symptoms (acute complications), stroke (macrovascular complications), diabetic peripheral neuropathy with severe pain (microvascular complications), extreme obesity (comorbidities), and insulin only or combined (management of diabetes). Good/excellent glucose control and noninsulin injectable showed higher values than T2DM without complications. The outcomes with the highest disutilities were amputation, depression, major hypoglycemia, stroke, and management using only insulin. Conclusions: We provide standardized, reliable utility values (or associated disutilities) for T2DM, acute, microvascular and macrovascular complications, related comorbidities and treatments that may support judgments when making clinical recommendations, designing decision support tools, and developing interventions and economic analysis.
AB - Objectives: We aimed to assess how patients value the importance of type 2 diabetes mellitus (T2DM) related outcomes. Methods: Overview of systematic reviews (SRs) reporting patients’ utilities or disutilities for T2DM outcomes. We searched 3 databases from inception until June 2021. Study selection and data extraction were conducted in pairs. We evaluated the quality of SRs with the Joanna Briggs Institute Checklist, and the overlap with the corrected covered area. We estimated descriptive statistics, and, when possible, conducted metanalysis. Results: We identified 11 SRs, including 119 studies and 70 outcomes. Most reviews were high-quality SRs. The outcomes with the lowest utilities were hypoglycemia with very severe symptoms (acute complications), stroke (macrovascular complications), diabetic peripheral neuropathy with severe pain (microvascular complications), extreme obesity (comorbidities), and insulin only or combined (management of diabetes). Good/excellent glucose control and noninsulin injectable showed higher values than T2DM without complications. The outcomes with the highest disutilities were amputation, depression, major hypoglycemia, stroke, and management using only insulin. Conclusions: We provide standardized, reliable utility values (or associated disutilities) for T2DM, acute, microvascular and macrovascular complications, related comorbidities and treatments that may support judgments when making clinical recommendations, designing decision support tools, and developing interventions and economic analysis.
UR - http://www.scopus.com/inward/record.url?scp=85170241105&partnerID=8YFLogxK
U2 - 10.1016/j.jval.2023.07.003
DO - 10.1016/j.jval.2023.07.003
M3 - Review article
C2 - 37516195
AN - SCOPUS:85170241105
SN - 1098-3015
VL - 26
SP - 1782
EP - 1794
JO - Value in Health
JF - Value in Health
IS - 12
ER -
