Hip and knee osteoarthritis (OA) are leading causes of global disability. Most research to date has focused on the knee, with results often extrapolated to the hip, and this extends to treatment recommendations in clinical guidelines. Extrapolating results from research on knee OA may limit our understanding of disease characteristics specific to hip OA, thereby constraining development and implementation of effective treatments. This review highlights differences between hip and knee OA with respect to prevalence, prognosis, epigenetics, pathophysiology, anatomical and biomechanical factors, clinical presentation, pain and non-surgical treatment recommendations and management.
Bibliographical noteRole of funding sources:
MH is supported by a National Health and Medical Research Council ( NHMRC ) Investigator Grant Emerging Leader 1 ( #1172928 ). RSH is supported by a NHMRC Senior Research Fellowship (#1154217 ). KLB is supported by a NHMRC Investigator Grant Leadership 2 ( #1174431 ). JQ is part-funded by an NIHR CRN (Clinical Research Networks) West Midlands Research Scholarship and part funded by the Haywood Foundation . The views expressed are those of the author(s) and not necessarily those of the NHS, NIHR or the Department of Health and Social Care. Funding sources had no role in study design, data design, data analysis, data interpretation or writing the manuscript.
© 2021 Osteoarthritis Research Society International