How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications? Comment

Dina Mönch, Marlies E.J. Reinders, Marc H. Dahlke, Martin J. Hoogduijn*

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

5 Citations (Scopus)
22 Downloads (Pure)


Mesenchymal stromal cells have been the subject of an expanding number of studies over the past decades. Today, over 75,000 publications are available that shine light on the biological properties and therapeutic effects of these versatile cells in numerous pre-clinical models and early-phase clinical trials. The massive number of papers makes it hard for researchers to comprehend the whole field, and furthermore, they give the impression that mesenchymal stromal cells are wonder cells that are curative for any condition. It is becoming increasingly difficult to dissect how and for what conditions mesenchymal stromal cells exhibit true and reproducible therapeutic effects. This article tries to address the question how to make sense of 75,000, and still counting, publications on mesenchymal stromal cells.

Original languageEnglish
Article number1419
Issue number9
Publication statusPublished - 22 Apr 2022

Bibliographical note

Funding: M.H.D. and D.M. are supported by the Robert Bosch Stiftung, Stuttgart (Credit-2021-6 to MHD). M.E.J.R. and M.J.H. received no external funding for this research.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


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